Abstract
MicroRNAs (miRNAs) are non-coding RNAs containing around 22 nucleotides, which are expressed in vertebrates and plants. They act as posttranscriptional gene expression regulators, fine-tuning various biological processes in different cell types. There is emerging evidence on their role in different stages of atherosclerosis. In addition to regulating the inflammatory cells involved in atherosclerosis, miRNAs play fundamental roles in the pathophysiology of atherosclerosis, such as endothelial cell (EC) dysfunction, the aberrant function of the vascular smooth muscle cell (VSMC) and cholesterol metabolism. Moreover, miRNAs participate in several pathogenic pathways of atherosclerotic plaque development, including their effects on immune cell signaling receptors and lipid uptake. In this study, we review our current knowledge of the regulatory role of miRNAs in various pathogenic pathways underlying atherosclerosis development and also outline potential clinical applications of miRNAs in atherosclerosis.
Keywords: MicroRNA, Atherosclerosis, Inflammation, Clinical application, Immune cells, endothelial cell (EC).
Current Drug Targets
Title:Implications of microRNAs in the Pathogenesis of Atherosclerosis and Prospects for Therapy
Volume: 22 Issue: 15
Author(s): Armita M. Gorabi, Mohsen Ghanbari, Thozhukat Sathyapalan, Tannaz Jamialahmadi and Amirhossein Sahebkar*
Affiliation:
- Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad,Iran
Keywords: MicroRNA, Atherosclerosis, Inflammation, Clinical application, Immune cells, endothelial cell (EC).
Abstract: MicroRNAs (miRNAs) are non-coding RNAs containing around 22 nucleotides, which are expressed in vertebrates and plants. They act as posttranscriptional gene expression regulators, fine-tuning various biological processes in different cell types. There is emerging evidence on their role in different stages of atherosclerosis. In addition to regulating the inflammatory cells involved in atherosclerosis, miRNAs play fundamental roles in the pathophysiology of atherosclerosis, such as endothelial cell (EC) dysfunction, the aberrant function of the vascular smooth muscle cell (VSMC) and cholesterol metabolism. Moreover, miRNAs participate in several pathogenic pathways of atherosclerotic plaque development, including their effects on immune cell signaling receptors and lipid uptake. In this study, we review our current knowledge of the regulatory role of miRNAs in various pathogenic pathways underlying atherosclerosis development and also outline potential clinical applications of miRNAs in atherosclerosis.
Export Options
About this article
Cite this article as:
Gorabi M. Armita , Ghanbari Mohsen , Sathyapalan Thozhukat , Jamialahmadi Tannaz and Sahebkar Amirhossein *, Implications of microRNAs in the Pathogenesis of Atherosclerosis and Prospects for Therapy, Current Drug Targets 2021; 22 (15) . https://dx.doi.org/10.2174/1389450122666210120143450
DOI https://dx.doi.org/10.2174/1389450122666210120143450 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Patent Selections
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Intraoperative Magnetic Resonance Imaging
Current Medical Imaging Cardioprotective Effects of Indian Gooseberry (Emblica officinalis Gaertn) and its Phytochemicals: A Review
Current Nutrition & Food Science Electrochemical-Based Biosensors: New Diagnosis Platforms for Cardiovascular Disease
Current Medicinal Chemistry Cardiac Workup of Ischemic Stroke
Current Cardiology Reviews Recent Patents Relating to Diagnostic Advances in Age Related Macular Degeneration (AMD)
Recent Patents on DNA & Gene Sequences MicroRNAs in Peripheral Artery Disease
Current Topics in Medicinal Chemistry 3D Printing in Modern Cardiology
Current Pharmaceutical Design A Cerebrovascular Image Segmentation Method Based on Geometrical Feature Point Clustering and Local Threshold
Current Medical Imaging Surgical Ventricular Restoration to Reverse Left Ventricular Remodeling
Current Cardiology Reviews Novel Aspects in the Pathophysiology of Peripheral Vasculopathy in Systemic Sclerosis
Current Rheumatology Reviews Apoptosis in Atherosclerosis: Virtue or Vice
Current Cardiology Reviews Breaking the Barrier in Stroke: What Should we Know? A Mini-Review
Current Pharmaceutical Design Novel Biomarkers Assessing the Calcium Deposition in Coronary Artery Disease
Current Medicinal Chemistry Multifunctional RNase MCPIP1 and its Role in Cardiovascular Diseases
Current Medicinal Chemistry Mechanosensitive Channels: Therapeutic Targets in the Myocardium?
Current Pharmaceutical Design Amphetamine-Type Medicines: A Review of Pharmacokinetics, Pharmacodynamics, and Toxicological Aspects.
Current Clinical Pharmacology Association between HbA1C (Glycated Hemoglobin) and Clinical Outcomes in Patients with Subarachnoid Hemorrhage After Neuro-intervention
Current Neurovascular Research Neuroimaging of Non-Accidental Injury
Current Pediatric Reviews Clinical and Forensic Signs Related to Cocaine Abuse
Current Drug Abuse Reviews