Abstract
Scandium radioisotopes are increasingly considered viable radiolabels for targeted molecular imaging (Sc-43, Sc-44) and therapy (Sc-47). Significant technological advances have increased the quantity and quality of available radioscandium in the past decade, motivated in part by the chemical similarity of scandium to therapeutic radionuclides like Lu-177. The production and radiochemical isolation techniques applied to scandium radioisotopes are reviewed, focusing on charged particle and electron linac initiated reactions and using calcium and titanium as starting materials.
Keywords: Scandium, cross-section, therapeutic radioisotopes, theranostics, PET, radioisotope production, radiochemical separation, radiometal, SPECT, radiolabeling.
Current Radiopharmaceuticals
Title:Accelerator Production of Scandium Radioisotopes: Sc-43, Sc-44, and Sc-47
Volume: 14 Issue: 4
Author(s): Margarita Chernysheva, Shaun C. Loveless, Tom Brossard, Kaelyn Becker, Shelbie Cingoranelli, Eduardo Aluicio-Sarduy, Jeongseong Song, Paul Ellison, Jerry Nolen, David A. Rotsch, Suzanne E. Lapi and Jonathan W. Engle*
Affiliation:
- Departments of Medical Physics and Radiology, University of Wisconsin Madison B1303 WIMR Cyclotron Laboratory, 1111 Highland Avenue, Madison WI 53705,United States
Keywords: Scandium, cross-section, therapeutic radioisotopes, theranostics, PET, radioisotope production, radiochemical separation, radiometal, SPECT, radiolabeling.
Abstract: Scandium radioisotopes are increasingly considered viable radiolabels for targeted molecular imaging (Sc-43, Sc-44) and therapy (Sc-47). Significant technological advances have increased the quantity and quality of available radioscandium in the past decade, motivated in part by the chemical similarity of scandium to therapeutic radionuclides like Lu-177. The production and radiochemical isolation techniques applied to scandium radioisotopes are reviewed, focusing on charged particle and electron linac initiated reactions and using calcium and titanium as starting materials.
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Chernysheva Margarita , Loveless C. Shaun , Brossard Tom , Becker Kaelyn , Cingoranelli Shelbie , Aluicio-Sarduy Eduardo , Song Jeongseong , Ellison Paul , Nolen Jerry , Rotsch A. David , Lapi E. Suzanne and Engle W. Jonathan *, Accelerator Production of Scandium Radioisotopes: Sc-43, Sc-44, and Sc-47, Current Radiopharmaceuticals 2021; 14 (4) . https://dx.doi.org/10.2174/1874471014999210112205535
DOI https://dx.doi.org/10.2174/1874471014999210112205535 |
Print ISSN 1874-4710 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-4729 |
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