A Review of Accelerator-Produced Ga-68 with Solid Targets

Title:A Review of Accelerator-Produced Ga-68 with Solid Targets

Volume: 14 Issue: 4

Author(s): Kaelyn V. Becker, Margarita Chernysheva, Todd E. Barnhart, Katherine Gagnon and Jonathan W. Engle*

Affiliation:

• Department of Medical Physics and Radiology, University of Wisconsin-Madison B1303 WIMR Cyclotron Laboratory, 1111 Highland Avenue, Madison WI 53705,United States

Keywords: Radiochemical, PET, therapeutic molecule, gallium-68, radiochemistry, Lu-177 labeled.

Abstract: Gallium-68 is a positron-emitting nuclide that has recently achieved clinical acceptance as the diagnostic radionuclide in PET tracers used for theranostic studies of lutetium-177 labeled therapeutic drugs due to the ease of access provided by germanium-68/gallium-68 generators. An alternative method of production currently being explored uses accelerators to form gallium-68 directly. This review of gallium-68 production strategies discusses available accelerator targetry at a range of beam energies and intensities, the many radiochemical separation techniques available to isolate Ga-68 from irradiated targets, isotopically enriched target material recovery, and the implications of these techniques for downstream radiolabeling applications.

Cite this article as:

Becker V. Kaelyn , Chernysheva Margarita , Barnhart E. Todd, Gagnon Katherine and Engle W. Jonathan *, A Review of Accelerator-Produced Ga-68 with Solid Targets, Current Radiopharmaceuticals 2021; 14 (4) . https://dx.doi.org/10.2174/1874471013666201224113651