Generic placeholder image

Current Respiratory Medicine Reviews

Editor-in-Chief

ISSN (Print): 1573-398X
ISSN (Online): 1875-6387

Mini-Review Article

Adenoid Hypertrophy, Craniofacial Growth and Obstructive Sleep Apnea: A Crucial Triad in Children

Author(s): Stanislav I. Volkov, Olga V. Ginter, Serghei Covantev* and Alexandru Corlateanu

Volume 16, Issue 3, 2020

Page: [144 - 155] Pages: 12

DOI: 10.2174/1573398X16999201202122440

Price: $65

Abstract

Age-related (physiological) AH is an important problem in pediatric otorhinolaryngology. Since the beginning of the 70s, there has been an increase in the proportion of children with pharyngeal tonsil hypertrophy. Functional disorders of the oropharynx in children occupy the second place based on their incidence (after disorders of the musculoskeletal system). In previous years, there has been an increase in the incidence and prevalence of obstructive sleep apnea syndrome (OSAS) among children. In most cases of pediatric OSAS, upper airway obstruction occurs from the nasopharynx to the oropharynx, caused by upper airway stenosis. Consequences of untreated OSAS in children can be inattention and behavioral problems, daytime sleepiness, and in more severe cases are associated with a variety of comorbidities. The current review discusses the links between hypertrophied adenoids, craniofacial development and OSAS in children taking into account physiological and pathophysiological aspects as well as clinical evaluation of the problem.

Keywords: Obstructive sleep apnea syndrome, adenoid, hypertrophy, craniofacial, growth, musculoskeletal system.

Graphical Abstract
[1]
Escarrá F, Vidaurreta SM. Assessment of quality of life before and after an adenotonsillectomy among children with hypertrophic tonsils and/or adenoids. Arch Argent Pediatr 2015; 113(1): 21-7.
[PMID: 25622157]
[2]
Rout MR, Mohanty D, Vijaylaxmi Y, Bobba K, Metta C. Adenoid hypertrophy in adults: a case series. Indian J Otolaryngol Head Neck Surg 2013; 65(3): 269-74.
[http://dx.doi.org/10.1007/s12070-012-0549-y]
[3]
Kara CO, Ergin H, Koçak G, Kılıç İ, Yurdakul M. Prevalence of tonsillar hypertrophy and associated oropharyngeal symptoms in primary school children in Denizli Int J Ped Otorhinol 2002; 66(2): 175-9.
[4]
Mummert A, Schoen M, Lampl M. Growth and life course health development. Handbook of Life Course Health Development 2018. Available from: https://www.ncbi.nlm.nih.gov/books/NBK543710/
[5]
Pereira L, Monyror J, Almeida FT, et al. Prevalence of adenoid hypertrophy: a systematic review and meta-analysis. Sleep Med Rev 2018; 38: 101-12.
[http://dx.doi.org/10.1016/j.smrv.2017.06.001] [PMID: 29153763]
[6]
Friberg D, Sundquist J, Li X, Hemminki K, Sundquist K. Sibling risk of pediatric obstructive sleep apnea syndrome and adenotonsillar hypertrophy. Sleep 2009; 32(8): 1077-83.
[http://dx.doi.org/10.1093/sleep/32.8.1077] [PMID: 19725259]
[7]
Tan H-L, Gozal D, Kheirandish-Gozal L. Obstructive sleep apnea in children: a critical update. Nat Sci Sleep 2013; 5: 109-23.
[PMID: 24109201]
[8]
Xu Z, Cheuk DK, Lee SL. Clinical evaluation in predicting childhood obstructive sleep apnea. Chest 2006; 130(6): 1765-71.
[http://dx.doi.org/10.1016/S0012-3692(15)50899-4] [PMID: 17166994]
[9]
Gulotta G, Iannella G, Vicini C, et al. Risk Factors for obstructive sleep apnea syndrome in children: state of the art. Int J Environ Res Public Health 2019; 16(18): 3235.
[http://dx.doi.org/10.3390/ijerph16183235] [PMID: 31487798]
[10]
Zeng G, Teng Y, Zhu J, Zhu D, Yang B, Hu L, et al. Clinical application of MRI-respiratory gating technology in the evaluation of children with obstructive sleep apnea hypopnea syndrome Medicine (Baltimore) 2018; 97(4): e9680.
[11]
Amin RS, Carroll JL, Jeffries JL, et al. Twenty-four-hour ambulatory blood pressure in children with sleep-disordered breathing. Am J Respir Crit Care Med 2004; 169(8): 950-6.
[http://dx.doi.org/10.1164/rccm.200309-1305OC] [PMID: 14764433]
[12]
Beebe DW, Wells CT, Jeffries J, Chini B, Kalra M, Amin R. Neuropsychological effects of pediatric obstructive sleep apnea. J Int Neuropsychol Soc 2004; 10(7): 962-75.
[http://dx.doi.org/10.1017/S135561770410708X] [PMID: 15803560]
[13]
Gozal D, Capdevila OS, Kheirandish-Gozal L. Metabolic alterations and systemic inflammation in obstructive sleep apnea among nonobese and obese prepubertal children. Am J Respir Crit Care Med 2008; 177(10): 1142-9.
[http://dx.doi.org/10.1164/rccm.200711-1670OC] [PMID: 18276939]
[14]
Gozal D, Crabtree VM, Sans Capdevila O, Witcher LA, Kheirandish-Gozal L. C-reactive protein, obstructive sleep apnea, and cognitive dysfunction in school-aged children. Am J Respir Crit Care Med 2007; 176(2): 188-93.
[http://dx.doi.org/10.1164/rccm.200610-1519OC] [PMID: 17400731]
[15]
Verhulst SL, Schrauwen N, Haentjens D, et al. Sleep-disordered breathing and the metabolic syndrome in overweight and obese children and adolescents. J Pediatr 2007; 150(6): 608-12.
[http://dx.doi.org/10.1016/j.jpeds.2007.01.051] [PMID: 17517244]
[16]
Corlateanu A, Botnaru V, Sircu V, Covantev S, Montanari G. Obstructive sleep apnea and type 2 diabetes: dual interaction. Curr Respir Med Rev 2015; 11(4): 292-8.
[http://dx.doi.org/10.2174/1573398X11666150915212520]
[17]
Sobiesk JL, Munakomi S. Head and Neck, Nasal Cavity. StatPearls Treasure Island (FL): StatPearls Publishing 2020. Available from: https://www.ncbi.nlm.nih.gov/books/NBK544232/
[18]
Meegalla N, Downs BW. Head and Neck, Palatine Tonsil (Faucial Tonsils). StatPearls Treasure Island (FL): StatPearls Publishing 2020. Available from: https://www.ncbi.nlm.nih.gov/books/NBK539792/
[19]
InformedHealth.org. Enlarged tonsils and adenoids: Overview 2006. Available from: https://www.ncbi.nlm.nih.gov/books/NBK536881/
[20]
Bowers I, Shermetaro C. Adenoiditis.StatPearls. Treasure Island, FL: StatPearls Publishing 2020. Available from: https://www.ncbi.nlm.nih.gov/books/NBK536931/
[21]
Di Francesco R, Monteiro R, Paulo ML, Buranello F, Imamura R. Craniofacial morphology and sleep apnea in children with obstructed upper airways: differences between genders. Sleep Med 2012; 13(6): 616-20.
[http://dx.doi.org/10.1016/j.sleep.2011.12.011] [PMID: 22459090]
[22]
Marseglia GL, Caimmi D, Pagella F, et al. Adenoids during childhood: the facts. Int J Immunopathol Pharmacol 2011; 24(4)(Suppl.): 1-5.
[http://dx.doi.org/10.1177/03946320110240S401] [PMID: 22032778]
[23]
Marseglia GL, Poddighe D, Caimmi D, et al. Role of adenoids and adenoiditis in children with allergy and otitis media. Curr Allergy Asthma Rep 2009; 9(6): 460-4.
[http://dx.doi.org/10.1007/s11882-009-0068-4] [PMID: 19814919]
[24]
Osiatuma VI, Otuyemi OD, Kolawole KA, Ogunbanjo BO, Amusa YB. Occlusal characteristics of children with hypertrophied adenoids in Nigeria. Int Orthod 2015; 13(1): 26-42.
[http://dx.doi.org/10.1016/j.ortho.2014.12.009] [PMID: 25665907]
[25]
Hao X, Wang JZ, Qu H. Effect of resection of adenoids and/or tonsil on the immune indexes in children with obstructive sleep apnea hypopnea syndrome Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019; 54(11): 830-6.
[PMID: 31795544]
[26]
Huang H, Zhang L, Zhang Q, Zhong J, Fu L, Mou Y. Comparison of the efficacy of two surgical procedures on adenoidal hypertrophy in children Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 2020; 27(2): 72-8.
[http://dx.doi.org/10.1016/j.arcped.2019.11.010]
[27]
O'Ryan FS, Gallagher DM, LaBanc JP, Epker BN. The relation between nasorespiratory function and dentofacial morphology: A review American Journal of Orthodontics 1982; 82(5): 403-10.
[http://dx.doi.org/10.1016/0002-9416(82)90189-0]
[28]
Thornval A. Wilhelm Meyer and the adenoids. Arch Otolaryngol 1969; 90(3): 383-6.
[http://dx.doi.org/10.1001/archotol.1969.00770030385023] [PMID: 4896109]
[29]
Chang SJ, Chae KY. Obstructive sleep apnea syndrome in children: Epidemiology, pathophysiology, diagnosis and sequelae Korean J Pediatr 2010; 53(10): 863-71.
[30]
Capdevila OS, Kheirandish-Gozal L, Dayyat E, Gozal D. Pediatric obstructive sleep apnea: complications, management, and long-term outcomes. Proc Am Thorac Soc 2008; 5(2): 274-82.
[http://dx.doi.org/10.1513/pats.200708-138MG] [PMID: 18250221]
[31]
Rijkers GT, Niers T, de Jager W, et al. Development of the immune system in the foetal and perinatal period In: CT Smit Sibinga, N Luban, Eds. neonatology and blood transfusion: proceedings of the twenty-eighth International symposium on blood transfusion, Groningen, NL organized by the sanquin division blood bank noord Nederland. Boston, MA. Springer US 2005; pp. 25-30.
[http://dx.doi.org/10.1007/978-0-387-23600-1_2]
[32]
Masters KG, Zezoff D, Lasrado S. Anatomy, Head and Neck, Tonsils.StatPearls Treasure Island, FL StatPearls Publishing. 2020. Available from: https://www.ncbi.nlm.nih.gov/books/NBK539792/
[33]
Soldatova L, Otero HJ, Saul DA, Barrera CA, Elden L. Lateral neck radiography in preoperative evaluation of adenoid hypertrophy. Ann Otol Rhinol Laryngol 2019.
[http://dx.doi.org/10.1177/0003489419895035] [PMID: 31868005]
[34]
Vogler RC, Ii FJ, Pilgram TK. Age-specific size of the normal adenoid pad on magnetic resonance imaging. Clin Otolaryngol Allied Sci 2000; 25(5): 392-5.
[http://dx.doi.org/10.1046/j.1365-2273.2000.00381.x] [PMID: 11012653]
[35]
Yildirim N, Sahan M, Karslioğlu Y. Adenoid hypertrophy in adults: clinical and morphological characteristics. J Int Med Res 2008; 36(1): 157-62.
[http://dx.doi.org/10.1177/147323000803600120] [PMID: 18304415]
[36]
Sousa JB, Anselmo-Lima WT, Valera FC, Gallego AJ, Matsumoto MA. Cephalometric assessment of the mandibular growth pattern in mouth-breathing children. Int J Pediatr Otorhinolaryngol 2005; 69(3): 311-7.
[http://dx.doi.org/10.1016/j.ijporl.2004.10.010] [PMID: 15733589]
[37]
Jacquier H, Vironneau P, Dang H, et al. Bacterial biofilm in adenoids of children with chronic otitis media. Part II: a case-control study of nasopharyngeal microbiota, virulence, and resistance of biofilms in adenoids. Acta Otolaryngol 2020; 140(3): 220-4.
[http://dx.doi.org/10.1080/00016489.2020.1718749] [PMID: 32049553]
[38]
Jaw TS, Sheu RS, Liu GC, Lin WC. Development of adenoids: a study by measurement with MR images. Kaohsiung J Med Sci 1999; 15(1): 12-8.
[PMID: 10063790]
[39]
Kang K-T, Chou C-H, Weng W-C, Lee P-L, Hsu W-C. Associations between adenotonsillar hypertrophy, age, and obesity in children with obstructive sleep apnea. PLoS One 2013; 8(10): e78666.
[40]
Marcus CL. Pathophysiology of childhood obstructive sleep apnea: current concepts. Respir Physiol 2000; 119(2-3): 143-54.
[http://dx.doi.org/10.1016/S0034-5687(99)00109-7] [PMID: 10722857]
[41]
Jeans WD, Fernando DC, Maw AR, Leighton BC. A longitudinal study of the growth of the nasopharynx and its contents in normal children. Br J Radiol 1981; 54(638): 117-21.
[http://dx.doi.org/10.1259/0007-1285-54-638-117] [PMID: 7459548]
[42]
Parikh SR, Coronel M, Lee JJ, Brown SM. Validation of a new grading system for endoscopic examination of adenoid hypertrophy. Otolaryngol Head Neck Surg 2006; 135(5): 684-7.
[http://dx.doi.org/10.1016/j.otohns.2006.05.003] [PMID: 17071294]
[43]
Cho JH, Lee DH, Lee NS, Won YS, Yoon HR, Suh BD. Size assessment of adenoid and nasopharyngeal airway by acoustic rhinometry in children. J Laryngol Otol 1999; 113(10): 899-905.
[http://dx.doi.org/10.1017/S0022215100145530] [PMID: 10664704]
[44]
Clemens J, McMurray JS, Willging JP. Electrocautery versus curette adenoidectomy: comparison of postoperative results. Int J Pediatr Otorhinolaryngol 1998; 43(2): 115-22.
[http://dx.doi.org/10.1016/S0165-5876(97)00159-6] [PMID: 9578120]
[45]
Lee A, Fan LT, Gin T, Karmakar MK, Ngan Kee WD. A systematic review (meta-analysis) of the accuracy of the Mallampati tests to predict the difficult airway. Anesth Analg 2006; 102(6): 1867-78.
[http://dx.doi.org/10.1213/01.ane.0000217211.12232.55] [PMID: 16717341]
[46]
Mallampati SR, Gatt SP, Gugino LD, et al. A clinical sign to predict difficult tracheal intubation: a prospective study. Can Anaesth Soc J 1985; 32(4): 429-34.
[http://dx.doi.org/10.1007/BF03011357] [PMID: 4027773]
[47]
Dayyat E, Kheirandish-Gozal L, Sans CO, Maarafeya MMA, Gozal D. Obstructive sleep apnea in children: relative contributions of body mass index and adenotonsillar hypertrophy Chest 2009; 136(1): 137-44.
[48]
Kim JH, Guilleminault C. The nasomaxillary complex, the mandible, and sleep-disordered breathing Sleep   breathing = Schlaf   Atmung 2011; 15(2): 185-93.
[http://dx.doi.org/10.1007/s11325-011-0504-2]
[49]
Feres MF, de Sousa HI, Francisco SM, Pignatari SS. Reliability of radiographic parameters in adenoid evaluation. Rev Bras Otorrinolaringol (Engl Ed) 2012; 78(4): 80-90.
[http://dx.doi.org/10.1590/S1808-86942012000400016] [PMID: 22936142]
[50]
Cohen D, Konak S. The evaluation of radiographs of the nasopharynx. Clin Otolaryngol Allied Sci 1985; 10(2): 73-8.
[http://dx.doi.org/10.1111/j.1365-2273.1985.tb01170.x] [PMID: 4028470]
[51]
Feres MFN, de Sousa HIP, Francisco SM, Pignatari SSN. Reliability of radiographic parameters in adenoid evaluation Brazilian journal of otorhinolaryngology 2012; 78(4): 80-90.
[52]
Kurien M, Lepcha A, Mathew J, Ali A, Jeyaseelan L. X-rays in the evaluation of adenoid hypertrophy: It’s role in the endoscopic era. Indian J Otolaryngol Head Neck Surg 2005; 57(1): 45-7.
[PMID: 23120124]
[53]
Elwany S. The adenoidal-nasopharyngeal ratio (AN ratio). Its validity in selecting children for adenoidectomy. J Laryngol Otol 1987; 101(6): 569-73.
[http://dx.doi.org/10.1017/S0022215100102269] [PMID: 3598357]
[54]
Fujioka M, Young LW, Girdany BR. Radiographic evaluation of adenoidal size in children: adenoidal-nasopharyngeal ratio. AJR Am J Roentgenol 1979; 133(3): 401-4.
[http://dx.doi.org/10.2214/ajr.133.3.401] [PMID: 111497]
[55]
Tang A, Benke JR, Cohen AP, Ishman SL. Influence of Tonsillar Size on OSA improvement in children undergoing adenotonsillectomy. Otolaryngol Head Neck Surg 2015; 153(2): 281-5.
[http://dx.doi.org/10.1177/0194599815583459] [PMID: 25940581]
[56]
Kuhle S, Hoffmann DU, Mitra S, Urschitz MS. Anti-inflammatory medications for obstructive sleep apnoea in children. Cochrane Database Syst Rev 2020; 1
[http://dx.doi.org/10.1002/14651858.CD007074.pub3] [PMID: 31978261]
[57]
Dayyat E, Kheirandish-Gozal L, Gozal D. Childhood obstructive sleep apnea: one or two distinct disease entities? Sleep Med Clin 2007; 2(3): 433-44.
[http://dx.doi.org/10.1016/j.jsmc.2007.05.004] [PMID: 18769509]
[58]
Ferguson KA, Ono T, Lowe AA, Ryan CF, Fleetham JA. The relationship between obesity and craniofacial structure in obstructive sleep apnea. Chest 1995; 108(2): 375-81.
[http://dx.doi.org/10.1378/chest.108.2.375] [PMID: 7634870]
[59]
Maeda K, Tsuiki S, Nakata S, Suzuki K, Itoh E, Inoue Y. Craniofacial contribution to residual obstructive sleep apnea after adenotonsillectomy in children: a preliminary study. J Clin Sleep Med 2014; 10(9): 973-7.
[http://dx.doi.org/10.5664/jcsm.4028] [PMID: 25142774]
[60]
Katyal V, Pamula Y, Daynes CN, et al. Craniofacial and upper airway morphology in pediatric sleep-disordered breathing and changes in quality of life with rapid maxillary expansion. Am J Orthod Dentofacial Orthop 2013; 144(6): 860-71.
[http://dx.doi.org/10.1016/j.ajodo.2013.08.015]
[61]
Diouf JS, Ngom PI, Sonko O, Diop-Bâ K, Badiane A, Diagne F. Influence of tonsillar grade on the dental arch measurements. Am J Orthod Dentofacial Orthop 2015; 147(2): 214-0.
[http://dx.doi.org/10.1016/j.ajodo.2014.10.028]
[62]
Quick CA, Gundlach KK. Adenoid facies. Laryngoscope 1978; 88(2 Pt 1): 327-33.
[http://dx.doi.org/10.1288/00005537-197802000-00014] [PMID: 621998]
[63]
Becking BE, Verweij JP, Kalf-Scholte SM, Valkenburg C, Bakker EWP, van Merkesteyn JPR. Impact of adenotonsillectomy on the dentofacial development of obstructed children: a systematic review and meta-analysis. Eur J Orthod 2017; 39(5): 509-18.
[http://dx.doi.org/10.1093/ejo/cjx005] [PMID: 28379334]
[64]
Sun Q, Hua F, He H. Adenotonsillectomy may have beneficial effects on the dentofacial development of children with adenotonsillar hypertrophy. J Evid Based Dent Pract 2018; 18(1): 73-5.
[http://dx.doi.org/10.1016/j.jebdp.2017.12.002] [PMID: 29478684]
[65]
Bueno DdeA, Grechi TH, Trawitzki LV, Anselmo-Lima WT, Felício CM, Valera FC. Muscular and functional changes following adenotonsillectomy in children. Int J Pediatr Otorhinolaryngol 2015; 79(4): 537-40.
[http://dx.doi.org/10.1016/j.ijporl.2015.01.024] [PMID: 25669724]
[66]
Macari AT, Bitar MA, Ghafari JG. New insights on age-related association between nasopharyngeal airway clearance and facial morphology. Orthod Craniofac Res 2012; 15(3): 188-97.
[http://dx.doi.org/10.1111/j.1601-6343.2012.01540.x] [PMID: 22812441]
[67]
Feres MF, Muniz TS, de Andrade SH, Lemos MdeM, Pignatari SS. Craniofacial skeletal pattern: is it really correlated with the degree of adenoid obstruction? Dental Press J Orthod 2015; 20(4): 68-75.
[http://dx.doi.org/10.1590/2176-9451.20.4.068-075.oar] [PMID: 26352848]
[68]
Peltomäki T. The effect of mode of breathing on craniofacial growth-revisited. Eur J Orthod 2007; 29(5): 426-9.
[http://dx.doi.org/10.1093/ejo/cjm055] [PMID: 17804427]
[69]
Pereira SR, Weckx LL, Ortolani CL, Bakor SF. Study of craniofacial alterations and of the importance of the rapid maxillary expansion after tonsillectomy. Rev Bras Otorrinolaringol (Engl Ed) 2012; 78(2): 111-7.
[http://dx.doi.org/10.1590/S1808-86942012000200017] [PMID: 22499378]
[70]
Zhang H. Adenoidal hypertrophy and the mandibular growth pattern in children. J Clin Otorhinol, Head, and Neck Surg 2013; 27(17): 955-8.
[PMID: 24358799]
[71]
Katyal V, Pamula Y, Martin AJ, Daynes CN, Kennedy JD, Sampson WJ. Craniofacial and upper airway morphology in pediatric sleep-disordered breathing: Systematic review and meta-analysis. Am J Orthod Dentofacial Orthop 2013; 143(1): 20-30.
[72]
Szalmás A, Papp Z, Csomor P, et al. Microbiological profile of adenoid hypertrophy correlates to clinical diagnosis in children. BioMed Res Int 2013; 2013: 629607.
[http://dx.doi.org/10.1155/2013/629607] [PMID: 24175295]
[73]
Koca CF, Erdem T, Bayındır T. The effect of adenoid hypertrophy on maxillofacial development: an objective photographic analysis. J Otolaryngol Head Neck Surg 2016; 45(1): 48.
[http://dx.doi.org/10.1186/s40463-016-0161-3] [PMID: 27647047]
[74]
Shen L, Lin Z, Lin X, Yang Z. Risk factors associated with obstructive sleep apnea-hypopnea syndrome in Chinese children: A single center retrospective case-control study PLoS One 2018; 13(9): e0203695.
[75]
Schwab RJ, Kim C, Bagchi S, et al. Understanding the anatomic basis for obstructive sleep apnea syndrome in adolescents. Am J Respir Crit Care Med 2015; 191(11): 1295-309.
[http://dx.doi.org/10.1164/rccm.201501-0169OC] [PMID: 25835282]
[76]
Huynh NT, Morton PD, Rompre PH, Papadakis A, Remise C. Associations between sleep-disordered breathing symptoms and facial and dental morphometry, assessed with screening examinations. Am J Orthod Dentofacial Orthop 2011; 140(6): 762-0.
[http://dx.doi.org/10.1016/j.ajodo.2011.03.023]
[77]
Raffat A, ul Hamid W. Cephalometric assessment of patients with adenoidal faces. J Pak Med Assoc 2009; 59(11): 747-52.
[PMID: 20361672]
[78]
Guilleminault C, Lee JH, Chan A. Pediatric obstructive sleep apnea syndrome. Arch Pediatr Adolesc Med 2005; 159(8): 775-85.
[http://dx.doi.org/10.1001/archpedi.159.8.775] [PMID: 16061787]
[79]
Michels DdS, Rodrigues AdMS, Nakanishi M, Sampaio ALL, Venosa AR. Nasal involvement in obstructive sleep apnea syndrome Int J Otolaryngol 2014; 717419.
[80]
Fairbanks DN. Effect of nasal surgery on snoring. South Med J 1985; 78(3): 268-70.
[http://dx.doi.org/10.1097/00007611-198503000-00009] [PMID: 3975737]
[81]
Serrano TLI, Pfeilsticker L, Silva V, et al. Newborn nasal obstruction due to congenital nasal pyriform aperture stenosis. Allergy Rhinol (Providence) 2016; 7(1): 37-41.
[http://dx.doi.org/10.2500/ar.2016.7.0146] [PMID: 27103559]
[82]
Baker K, Pereira K. Congenital nasal pyriform aperture stenosis. Oper Tech Otolaryngol 2009; 20: 178-82.
[http://dx.doi.org/10.1016/j.otot.2009.11.001]
[83]
Navruzov KT, Mahsudov NS, Khasanov SA. Study of the effect of nasal breathing difficulties on the growth and development of the dental system in children Russian rhinology 2001; 4: 14-6.
[84]
Fiorita A, Scarano E, Mastrapasqua R, et al. Moderate OSAS and turbinate decongestion: surgical efficacy in improving the quality of life and compliance of CPAP using Epworth score and SNOT-20 score. Acta Otorhinolaryngol Ital 2018; 38(3): 214-21.
[PMID: 29984797]
[85]
Abdel Tawab HM, Tabook SMS. Correlation between adenoid hypertrophy, tympanometry findings, and viscosity of middle ear fluid in chronic otitis media with effusion, Southern Oman. Ear Nose Throat J 2019.
[http://dx.doi.org/10.1177/0145561319875438] [PMID: 31547716]
[86]
Volkov AG, Lebedenko AA, Kiriy GI. Cluster analysis of risk factors for pharyngeal amygdala hypertrophy in children. Medical Bulletin of the South of Russia 2015; 4: 31-5.
[87]
Salman N, Ozturk G, Akin I, Kilicaslan S, Demirel F, Delibas N. The effect of adenotonsilectomy on ghrelin, leptin, IGF-1 levels and growth parameters in children with adenotonsillar hypertrophy. J Pediatr Endocrinol Metab 2014; 27(9-10): 885-90.
[http://dx.doi.org/10.1515/jpem-2013-0367] [PMID: 24854528]
[88]
Seren E, San T, Cingi C, Muluk NB, Durukan K. Effects of body mass index and adenotonsillar size on snoring sound intensity levels at highest power. Int J Pediatr Otorhinolaryngol 2014; 78(1): 50-4.
[http://dx.doi.org/10.1016/j.ijporl.2013.10.017] [PMID: 24268721]
[89]
Xue XC, Chen XP, Yao WH, Zhang Y, Sun GB, Tan XJ. Prevalence of human papillomavirus and Epstein-Barr virus DNA in Chinese children with tonsillar and/or adenoidal hypertrophy. J Med Virol 2014; 86(6): 963-7.
[http://dx.doi.org/10.1002/jmv.23894] [PMID: 24615954]
[90]
Kurnatowski P, Putyński L, Łapienis M, Kowalska B. Physical and emotional disturbances in children with adenotonsillar hypertrophy. J Laryngol Otol 2008; 122(9): 931-5.
[http://dx.doi.org/10.1017/S0022215107001235] [PMID: 18047762]
[91]
Friedman BC, Hendeles-Amitai A, Kozminsky E, et al. Adenotonsillectomy improves neurocognitive function in children with obstructive sleep apnea syndrome. Sleep 2003; 26(8): 999-1005.
[http://dx.doi.org/10.1093/sleep/26.8.999] [PMID: 14746381]
[92]
Gozal D. Sleep-disordered breathing and school performance in children. Pediatrics 1998; 102(3 Pt 1): 616-20.
[http://dx.doi.org/10.1542/peds.102.3.616] [PMID: 9738185]
[93]
Galland B, Spruyt K, Dawes P, McDowall PS, Elder D, Schaughency E. Sleep disordered breathing and academic performance: a meta-analysis. Pediatrics 2015; 136(4): e934-46.
[http://dx.doi.org/10.1542/peds.2015-1677] [PMID: 26347434]
[94]
Perfect MM, Archbold K, Goodwin JL, Levine-Donnerstein D, Quan SF. Risk of behavioral and adaptive functioning difficulties in youth with previous and current sleep disordered breathing. Sleep (Basel) 2013; 36(4): 517-525B.
[http://dx.doi.org/10.5665/sleep.2536] [PMID: 23543901]
[95]
Chervin RD, Hedger K, Dillon JE, Pituch KJ. Pediatric sleep questionnaire (PSQ): validity and reliability of scales for sleep-disordered breathing, snoring, sleepiness, and behavioral problems. Sleep Med 2000; 1(1): 21-32.
[http://dx.doi.org/10.1016/S1389-9457(99)00009-X] [PMID: 10733617]
[96]
Marcus CL, Keens TG, Ward SL. Comparison of nap and overnight polysomnography in children. Pediatr Pulmonol 1992; 13(1): 16-21.
[http://dx.doi.org/10.1002/ppul.1950130106] [PMID: 1589307]
[97]
Saeed MM, Keens TG, Stabile MW, Bolokowicz J, Davidson Ward SL. Should children with suspected obstructive sleep apnea syndrome and normal nap sleep studies have overnight sleep studies? Chest 2000; 118(2): 360-5.
[http://dx.doi.org/10.1378/chest.118.2.360] [PMID: 10936125]
[98]
Kooanantkul C, Kuptanon T, Preutthipan A. Can nap polysomnography predict obstructive sleep apnea syndrome in snoring children? - A Pilot Study. Chest 2015; 148(4): 1051A.
[http://dx.doi.org/10.1378/chest.2243668]
[99]
Kirk V, Baughn J, D’Andrea L, et al. American Academy of Sleep Medicine Position Paper for the Use of a Home Sleep Apnea Test for the Diagnosis of OSA in Children. J Clin Sleep Med 2017; 13(10): 1199-203.
[http://dx.doi.org/10.5664/jcsm.6772] [PMID: 28877820]
[100]
Corlateanu A, Covantev S, Botnaru V, Sircu V, Nenna R. To sleep, or not to sleep - that is the question, for polysomnography. Breathe (Sheff) 2017; 13(2): 137-40.
[http://dx.doi.org/10.1183/20734735.007717] [PMID: 28620435]
[101]
Tan HL, Gozal D, Ramirez HM, Bandla HP, Kheirandish-Gozal L. Overnight polysomnography versus respiratory polygraphy in the diagnosis of pediatric obstructive sleep apnea. Sleep (Basel) 2014; 37(2): 255-60.
[http://dx.doi.org/10.5665/sleep.3392] [PMID: 24497654]
[102]
Alonso-Álvarez ML, Terán-Santos J, Ordax Carbajo E, et al. Reliability of home respiratory polygraphy for the diagnosis of sleep apnea in children. Chest 2015; 147(4): 1020-8.
[http://dx.doi.org/10.1378/chest.14-1959] [PMID: 25539419]
[103]
Gozal D, Kheirandish-Gozal L, Kaditis AG. Home sleep testing for the diagnosis of pediatric obstructive sleep apnea: the times they are a changing Curr Opin Pulm Med 2015; 21(6): 563-8.
[104]
Jonas C, Thavagnanam S, Blecher G, Thambipillay G, Teng AY. Comparison of nocturnal pulse oximetry with polysomnography in children with sleep disordered breathing Sleep and Breathing 2020; 24(2): 703-.
[105]
Suliman L, Shalabi N, Saad A. Validity of overnight pulse oximetry as a screening tool of obstructive sleep apnea. Eur Respir J 2016; 48(Suppl. 60): PA2316.
[106]
Burke RM, Maxwell B, Hunter C, Graham D, O’Donoghue D, Shields MD. Night-to-night variation of pulse oximetry in children with sleep-disordered breathing. Arch Dis Child 2016; 101(12): 1095-9.
[http://dx.doi.org/10.1136/archdischild-2015-308981] [PMID: 26969584]
[107]
Sivan Y, Kornecki A, Schonfeld T. Screening obstructive sleep apnoea syndrome by home videotape recording in children. Eur Respir J 1996; 9(10): 2127-31.
[http://dx.doi.org/10.1183/09031936.96.09102127] [PMID: 8902478]
[108]
Arens R, Muzumdar H. Childhood obesity and obstructive sleep apnea syndrome J Appl Physiol 2010; 108(2): 436-4.
[109]
Zhang XQ, Wang H, Zhou J, Zeng P, Zhao Y, Zhang Y, et al. Efficacy of minimally invasive tonsil surgery for treatment of obstructive sleep apnea-hypopnea syndrome in children Braz J Med Biol Res 2017; 50(5): e5846.
[http://dx.doi.org/10.1590/1414-431x20175846]
[110]
Nandalike K, Shifteh K, Sin S, et al. Adenotonsillectomy in obese children with obstructive sleep apnea syndrome: magnetic resonance imaging findings and considerations. Sleep (Basel) 2013; 36(6): 841-7.
[http://dx.doi.org/10.5665/sleep.2708] [PMID: 23729927]
[111]
Com G, Carroll JL, Tang X, Melguizo MS, Bower C, Jambhekar S. Characteristics and surgical and clinical outcomes of severely obese children with obstructive sleep apnea. J Clin Sleep Med 2015; 11(4): 467-74.
[http://dx.doi.org/10.5664/jcsm.4608] [PMID: 25665695]
[112]
Domany KA, Dana E, Tauman R, et al. Adenoidectomy for Obstructive Sleep Apnea in Children. J Clin Sleep Med 2016; 12(9): 1285-91.
[http://dx.doi.org/10.5664/jcsm.6134] [PMID: 27448429]
[113]
Huang Y-S, Guilleminault C, Lee L-A, Lin C-H, Hwang F-M. Treatment outcomes of adenotonsillectomy for children with obstructive sleep apnea: a prospective longitudinal study. Sleep (Basel) 2014; 37(1): 71-6.
[http://dx.doi.org/10.5665/sleep.3310] [PMID: 24470697]
[114]
Quante M, Wang R, Weng J, et al. Childhood Adenotonsillectomy Trial (CHAT). The Effect of Adenotonsillectomy for Childhood Sleep Apnea on Cardiometabolic Measures. Sleep (Basel) 2015; 38(9): 1395-403.
[http://dx.doi.org/10.5665/sleep.4976] [PMID: 25669177]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy