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Coronaviruses

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ISSN (Print): 2666-7967
ISSN (Online): 2666-7975

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Short Communication

Does Hypofractionated Radiotherapy Regimens Increase the Vulnerability to SARS- COV-2 by Influencing ACE-2 Activity?

Author(s): Ghofrane Salhi Cherkaoui*, Sara Taleb, Youness Kadil and Houda Filali

Volume 2, Issue 4, 2021

Published on: 09 November, 2020

Page: [419 - 421] Pages: 3

DOI: 10.2174/2666796701999201109213143

Abstract

In the context of the novel Coronavirus pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the management of patients with cancer constitutes a real challenge. These patients are more likely to be immunocompromised due to the underlying malignancy or anticancer treatments. As a consequence, they are more at risk of contracting this virus and tend to show a higher rate of fatal cases. In order to reduce the risk of this pandemic among patients and health care professionals, oncologists are currently proposing hypofractionated radiotherapy regimens using higher doses per fraction, thus shortening treatment courses and saving treatment visits. Since higher doses of radiation may also increase the ACE/ACE2 activity, which has been identified as a key SARS-CoV-2 receptor, this paper raises the question of whether hypofractionated radiotherapy regimens further increase the infectivity of these already vulnerable patients.

Keywords: Irradiation, radiation exposure, radiotherapy, SARS CoV 2, coronavirus, angiotensin converting enzyme (ACE), ACE2.

[1]
Al-Shamsi HO, Alhazzani W, Alhuraiji A, et al. A practical approach to the management of cancer patients during the novel coronavirus disease 2019 (COVID-19) pandemic: an international collaborative group. Oncologist 2020; 25(6): e936-45.
[http://dx.doi.org/10.1634/theoncologist.2020-0213]
[2]
Jazieh A-R, Alenazi T H, Alhejazi A, Al Safi F, Al Olayan A. Outcome of oncology patients infected with coronavirus JCO Glob Oncol 2020; 6: 471-5.
[http://dx.doi.org/10.1200/GO.20.00064]
[3]
Wei W, Zheng D, Lei Y, et al. Radiotherapy workflow and protection procedures during the coronavirus disease 2019 (COVID-19) outbreak: experience of the hubei cancer hospital in Wuhan, China. Radiother Oncol 2020; 148(mars): 203-10.
[http://dx.doi.org/10.1016/j.radonc.2020.03.029] [PMID: 32342870]
[4]
Coles CE, Aristei C, Bliss J, et al. International guidelines on radiation therapy for breast cancer during the COVID-19 pandemic. Clin Oncol (R Coll Radiol) 2020; 32(5): 279-81.
[http://dx.doi.org/10.1016/j.clon.2020.03.006] [PMID: 32241520]
[5]
Al-Rashdan A, Roumeliotis M, Quirk S, et al. Adapting radiation therapy treatments for patients with breast cancer during the COVID-19 pandemic: hypo-fractionation and accelerated partial breast irradiation to address world health organization recommendations. Adv Radiat Oncol 2020; 5: 575-6.
[http://dx.doi.org/10.1016/j.adro.2020.03.011] [PMID: 32363244]
[6]
Krengli M, Ferrara E, Mastroleo F, Brambilla M, Ricardi U. Running a radiation oncology department at the time of coronavirus: An Italian experience. Adv Radiat Oncol 2020; 5(4): 527-30.
[http://dx.doi.org/10.1016/j.adro.2020.03.003] [PMID: 32292837]
[7]
Simcock R, Thomas TV, Estes C, et al. COVID-19: Global radiation oncology’s targeted response for pandemic preparedness. Clin Transl Radiat Oncol 2020; 22: 55-68.
[http://dx.doi.org/10.1016/j.ctro.2020.03.009] [PMID: 32274425]
[8]
Donoghue M, Hsieh F, Baronas E, et al. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res 2000; 87(5): E1-9.
[http://dx.doi.org/10.1161/01.RES.87.5.e1] [PMID: 10969042]
[9]
Tipnis SR, Hooper NM, Hyde R, Karran E, Christie G, Turner AJ. A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J Biol Chem 2000; 275(43): 33238-43.
[http://dx.doi.org/10.1074/jbc.M002615200] [PMID: 10924499]
[10]
Thomas M, Tikellis C. ACE2; an ACE up the Sleeve? Curr Enzym Inhib 2005; 1(1): 51-63.
[http://dx.doi.org/10.2174/1573408052952739]
[11]
Rivière G, Michaud A, Breton C, et al. Angiotensin-converting enzyme 2 (ACE2) and ACE activities display tissue-specific sensitivity to undernutrition-programmed hypertension in the adult rat. Hypertension 2005; 46(5): 1169-74.
[http://dx.doi.org/10.1161/01.HYP.0000185148.27901.fe] [PMID: 16203874]
[12]
Chung MK, Karnik S, Saef J, et al. SARS-CoV-2 and ACE2: The biology and clinical data settling the ARB and ACEI controversy. EBioMedicine 2020; 58102907
[http://dx.doi.org/10.1016/j.ebiom.2020.102907] [PMID: 32771682]
[13]
Kuba K, Imai Y, Ohto-Nakanishi T, Penninger JM. Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters. Pharmacol Ther 2010; 128(1): 119-28.
[http://dx.doi.org/10.1016/j.pharmthera.2010.06.003] [PMID: 20599443]
[14]
Li W, Moore MJ, Vasilieva N, et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 2003; 426(6965): 450-4.
[http://dx.doi.org/10.1038/nature02145] [PMID: 14647384]
[15]
Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020; 579(7798): 270-3.
[http://dx.doi.org/10.1038/s41586-020-2012-7] [PMID: 32015507]
[16]
Kharwade RS, More SM. Coordinated Roadmap to Grip Pandemic Covid-19. Coronaviruses 2020; 1: 1.
[http://dx.doi.org/10.2174/2666796701999200801023110]
[17]
Meyer KR, Witschi H, Ullrich RL. Proliferative responses of type 2 lung epithelial cells after X rays and fission neutrons. Radiat Res 1980; 82(3): 559-69.
[http://dx.doi.org/10.2307/3575322] [PMID: 7384420]
[18]
Widlak P, Jelonek K, Wojakowska A, et al. Serum proteome signature of radiation response: upregulation of inflammation-related factors and downregulation of apolipoproteins and coagulation factors in cancer patients treated with radiation therapy--a pilot study. Int J Radiat Oncol Biol Phys 2015; 92(5): 1108-15.
[http://dx.doi.org/10.1016/j.ijrobp.2015.03.040] [PMID: 26031365]
[19]
Templin T, Paul S, Amundson SA, et al. Radiation-induced micro-RNA expression changes in peripheral blood cells of radiotherapy patients. Int J Radiat Oncol Biol Phys 2011; 80(2): 549-57.
[http://dx.doi.org/10.1016/j.ijrobp.2010.12.061] [PMID: 21420249]
[20]
Orfanos SE, Chen XL, Ryan JW, Chung AYK, Burch SE, Catravas JD. Assay of pulmonary microvascular endothelial angiotensin-converting enzyme in vivo: comparison of three probes. Toxicol Appl Pharmacol 1994; 124(1): 99-111.
[http://dx.doi.org/10.1006/taap.1994.1013] [PMID: 8291066]
[21]
Korystova AF, Kublik LN, Levitman MKh, Samokhvalova TV, Shaposhnikova VV, Korystov YN. Ionizing radiation enhances activity of angiotensin-converting enzyme in rat aorta. Bull Exp Biol Med 2018; 165(2): 216-9.
[http://dx.doi.org/10.1007/s10517-018-4133-7] [PMID: 29922997]
[22]
Aleksova A, Ferro F, Gagno G, et al. COVID‐19 and renin‐angiotensin system inhibition: role of angiotensin converting enzyme 2 (ACE2) ‐ Is there any scientific evidence for controversy? 2020; 288: 410-21.
[http://dx.doi.org/10.1111/joim.13101]
[23]
Wysocki J, Ye M, Soler MJ, et al. ACE and ACE2 activity in diabetic mice. Diabetes 2006; 55(7): 2132-9.
[http://dx.doi.org/10.2337/db06-0033] [PMID: 16804085]
[24]
de Souza AMA, West CA, de Abreu ARR, et al. Role of the renin angiotensin system in blood pressure allostasis-induced by severe food restriction in female fischer rats. Sci Rep 2018; 8(1): 10327.
[http://dx.doi.org/10.1038/s41598-018-28593-6] [PMID: 29985423]
[25]
Chappel MC, Ferrario CM. ACE and ACE2: their role to balance the expression of angiotensin II and angiotensin-(1-7). Kidney Int 2006; 70(1): 8-10.
[http://dx.doi.org/10.1038/sj.ki.5000321] [PMID: 16810285]

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