Generic placeholder image

Current Bioactive Compounds

Editor-in-Chief

ISSN (Print): 1573-4072
ISSN (Online): 1875-6646

Mini-Review Article

The Multifarious Medical Applications of Carbon Curvatures: A Cohort review

Author(s): Vishal Chavda* and Vimal Patel

Volume 17, Issue 6, 2021

Published on: 20 October, 2020

Article ID: e010621187052 Pages: 5

DOI: 10.2174/1573407216999201020202903

Price: $65

Abstract

Carbon curvatures are novel therapeutic bio-material that are being studied due to its multifarious applications in a variety of research aspects. All the carbon allotropes were grouped mathematically into three types based upon surface Gaussian curvatures: zero curvature (graphene), negative curvature (schwarzites), and positive curvature (fullerenes, CNTs), because they have physiochemical activities, such as optoelectrical, chemical, thermal and magnetic properties. All these allotropes consist of sp2 hybridization with delocalized π bond electrons. Based on the types and number of aromatic carbon rings, all ofthese have unique geometric structural characteristics, chirality, and solubility, which offers them as a potential candidate for biomedical and therapeutic applications. In this short review, we highlight the basic structural and physicochemical characteristics of carbon allotropes and their biomedical and therapeutic applications recentlystudied by researchers and describe the therapeutic applications of graphene and its derivatives in drug delivery, gene delivery, bio-imaging, biosensors, therapeutic diagnosis, and photo-stimulation therapies.

Keywords: Carbon curvatures, drug-gene delivery, fluorescence imaging, photodynamic therapy, praphene, gene delivery.

Graphical Abstract
[1]
Zhang Z, Chen J, Li B. Negative Gaussian curvature induces significant suppression of thermal conduction in carbon crystals. Nanoscale 2017; 9(37): 14208-14.
[http://dx.doi.org/10.1039/C7NR04944G] [PMID: 28914316]
[2]
Pun SH, Miao Q. Toward negatively curved carbons. Acc Chem Res 2018; 51(7): 1630-42.
[http://dx.doi.org/10.1021/acs.accounts.8b00140] [PMID: 29974752]
[3]
Lenosky T, Gonze X, Teter M, Elser V. Energetics of negatively curved graphitic carbon. Nature 1992; 355(6358): 333.
[http://dx.doi.org/10.1038/355333a0]
[4]
Sharma P, Mehra NK, Jain K, Jain NK. Biomedical applications of carbon nanotubes: a critical review. Curr Drug Deliv 2016; 13(6): 796-817.
[http://dx.doi.org/10.2174/1567201813666160623091814] [PMID: 27339036]
[5]
Zheng XT, Ananthanarayanan A, Luo KQ, Chen P. Glowing graphene quantum dots and carbon dots: properties, syntheses, and biological applications. Small 2015; 11(14): 1620-36.
[http://dx.doi.org/10.1002/smll.201402648] [PMID: 25521301]
[6]
Xu X, Ray R, Gu Y, et al. Electrophoretic analysis and purification of fluorescent single-walled carbon nanotube fragments. J Am Chem Soc 2004; 126(40): 12736-7.
[http://dx.doi.org/10.1021/ja040082h] [PMID: 15469243]
[7]
Benedek G, Bernasconi M, Cinquanta E, D’Alessio L, De Corato M. The topological background of schwarzite physics InThe Mathematics and Topology of Fullerenes Dordrecht: Springer. Dordrecht: Springer 2011; pp. pp 217-47.
[http://dx.doi.org/10.1007/978-94-007-0221-9_12]
[8]
Prajapati VK, Awasthi K, Gautam S, et al. Targeted killing of Leishmania donovani in vivo and in vitro with amphotericin B attached to functionalized carbon nanotubes. J Antimicrob Chemother 2011; 66(4): 874-9.
[http://dx.doi.org/10.1093/jac/dkr002] [PMID: 21393222]
[9]
Ajima K, Yudasaka M, Murakami T, Maigné A, Shiba K, Iijima S. Carbon nanohorns as anticancer drug carriers. Mol Pharm 2005; 2(6): 475-80.
[http://dx.doi.org/10.1021/mp0500566] [PMID: 16323954]
[10]
Ni Z, Yu H, Wang L, et al. Recent research progress on polyphosphazene-based drug delivery systems. J Mater Chem B Mater Biol Med 2020; 8(8): 1555-75.
[http://dx.doi.org/10.1039/C9TB02517K] [PMID: 32025683]
[11]
Chekin F, Myshin V, Ye R, et al. Graphene-modified electrodes for sensing doxorubicin hydrochloride in human plasma. Anal Bioanal Chem 2019; 411(8): 1509-16.
[http://dx.doi.org/10.1007/s00216-019-01611-w] [PMID: 30739196]
[12]
Perepelytsina OM, Ugnivenko AP, Dobrydnev AV, Bakalinska ON, Marynin AI, Sydorenko MV. Influence of Carbon Nanotubes and Its Derivatives on Tumor Cells In Vitro and Biochemical Parameters, Cellular Blood Composition In Vivo. Nanoscale Res Lett 2018; 13(1): 286.
[http://dx.doi.org/10.1186/s11671-018-2689-9] [PMID: 30209630]
[13]
Cirillo G, Hampel S, Spizzirri UG, Parisi OI, Picci N, Iemma F. Carbon nanotubes hybrid hydrogels in drug delivery: a perspective review. BioMed Res Int 2014; 2014: 825017.
[http://dx.doi.org/10.1155/2014/825017] [PMID: 24587993]
[14]
Ito Y, Venkatesan N, Hirako N, Sugioka N, Takada K. Effect of fiber length of carbon nanotubes on the absorption of erythropoietin from rat small intestine. Int J Pharm 2007; 337(1-2): 357-60.
[http://dx.doi.org/10.1016/j.ijpharm.2006.12.042] [PMID: 17270373]
[15]
Ali I, Basheer AA, Kucherova A, et al. Advances in carbon nanomaterials as lubricants modifiers. J Mol Liq 2019; 279(February): 251-66.
[http://dx.doi.org/10.1016/j.molliq.2019.01.113]
[16]
Diana B, Ali E, Graphene AVS. a new emerging lubricant. Mater Today 2014; 17(1): 31-42.
[http://dx.doi.org/10.1016/j.mattod.2013.12.003]
[17]
Dorri Moghadam A, Omrani E, Menezes PL, Rohatgi PK. Mechanical and tribological properties of self-lubricating metal matrix nanocomposites reinforced by carbon nanotubes (CNTs) and graphene - A review. Compos, Part B Eng 2015; 77: 402-20.
[http://dx.doi.org/10.1016/j.compositesb.2015.03.014]
[18]
Munk M, De Souza Salomão Zanette R, De Almeida Camargo LS, et al. Using carbon nanotubes to deliver genes to hard-to-transfect mammalian primary fibroblast cells. Biomed Phys Eng Express 2017; 3(4): 1-12.
[http://dx.doi.org/10.1088/2057-1976/aa7927]
[19]
Vincent M, de Lázaro I, Kostarelos K. Graphene materials as 2D non-viral gene transfer vector platforms. Gene Ther 2017; 24(3): 123-32.
[http://dx.doi.org/10.1038/gt.2016.79] [PMID: 27874854]
[20]
Zhao H, Ding R, Zhao X, et al. Graphene-based nanomaterials for drug and/or gene delivery, bioimaging, and tissue engineering. Drug Discov Today 2017; 22(9): 1302-17.
[http://dx.doi.org/10.1016/j.drudis.2017.04.002] [PMID: 28869820]
[21]
Williams RM, Nayeem S, Dolash BD, Sooter LJ. The effect of DNA-dispersed single-walled carbon nanotubes on the polymerase chain reaction. PLoS One 2014; 9(4): e94117.
[http://dx.doi.org/10.1371/journal.pone.0094117] [PMID: 24705714]
[22]
Wang Y, Wang F, Wang H, Song M. Graphene oxide enhances the specificity of the polymerase chain reaction by modifying primer-template matching. Sci Rep 2017; 7(1): 16510.
[http://dx.doi.org/10.1038/s41598-017-16836-x] [PMID: 29184216]
[23]
Yang K, Feng L, Shi X, Liu Z. Nano-graphene in biomedicine: theranostic applications. Chem Soc Rev 2013; 42(2): 530-47.
[http://dx.doi.org/10.1039/C2CS35342C] [PMID: 23059655]
[24]
Viseu T, Lopes CM, Fernandes E, Oliveira MECDR, Lúcio M. A systematic review and critical analysis of the role of graphene-based nanomaterials in cancer theranostics. Pharmaceutics 2018; 10(4): 2-45.
[http://dx.doi.org/10.3390/pharmaceutics10040282] [PMID: 30558378]
[25]
Hortelão AC, Patiño T, Perez-Jiménez A, Blanco À, Sánchez S. Enzyme-powered nanobots enhance anticancer drug delivery. Adv Funct Mater 2018; 28(25): 1-10.
[http://dx.doi.org/10.1002/adfm.201705086]
[26]
Medina-Sánchez M, Xu H, Schmidt OG. Micro- and nano-motors: the new generation of drug carriers. Ther Deliv 2018; 9(4): 303-16.
[http://dx.doi.org/10.4155/tde-2017-0113] [PMID: 29540126]
[27]
Zhai X, Zhang P, Liu C, et al. Highly luminescent carbon nanodots by microwave-assisted pyrolysis. Chem Commun (Camb) 2012; 48(64): 7955-7.
[http://dx.doi.org/10.1039/c2cc33869f] [PMID: 22763501]
[28]
Cao L, Wang X, Meziani MJ, et al. Carbon dots for multiphoton bioimaging. J Am Chem Soc 2007; 129(37): 11318-9.
[http://dx.doi.org/10.1021/ja073527l] [PMID: 17722926]
[29]
Kong B, Zhu A, Ding C, Zhao X, Li B, Tian Y. Carbon dot-based inorganic-organic nanosystem for two-photon imaging and biosensing of pH variation in living cells and tissues. Adv Mater 2012; 24(43): 5844-8.
[http://dx.doi.org/10.1002/adma.201202599] [PMID: 22933395]
[30]
Roy P, Periasamy AP, Lin CY, et al. Photoluminescent graphene quantum dots for in vivo imaging of apoptotic cells. Nanoscale 2015; 7(6): 2504-10.
[http://dx.doi.org/10.1039/C4NR07005D] [PMID: 25569453]
[31]
Wu C, Wang C, Han T, Zhou X, Guo S, Zhang J. Insight into the cellular internalization and cytotoxicity of graphene quantum dots. Adv Healthc Mater 2013; 2(12): 1613-9.
[http://dx.doi.org/10.1002/adhm.201300066] [PMID: 23703800]
[32]
Nasrollahi F, Koh YR, Chen P, Varshosaz J, Khodadadi AA, Lim S. Targeting graphene quantum dots to epidermal growth factor receptor for delivery of cisplatin and cellular imaging. Mater Sci Eng C 2019; 94(Jan): 247-57.
[http://dx.doi.org/10.1016/j.msec.2018.09.020] [PMID: 30423706]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy