Acute Toxicity Analysis and Antidiabetic Effect of the Moroccan Spider Flower (Cleome Arabica L.) in Normal and Sreptozotocin-Induced Diabetic Rats

Title:Acute Toxicity Analysis and Antidiabetic Effect of the Moroccan Spider Flower (Cleome Arabica L.) in Normal and Sreptozotocin-Induced Diabetic Rats

Volume: 21 Issue: 8

Author(s): Ayoub Amssayef and Mohamed Eddouks*

Affiliation:

• Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, 52000, Errachidia,Morocco

Keywords: Cleome arabica L., streptozotocin, diabetes, aqueous extract, acute toxicity, antidiabetic effect, medicinal plant.

Abstract:

Aims: The study aimed to assess the antihyperglycemic effect of Cleome arabica.

Background: Cleome arabica L. or spider flower belongs to the Capparidaceae family and it is used for treating inflammation and diabetes mellitus in traditional medicine.

Objective: This study aimed to evaluate the antihyperglycemic activity and acute toxicity of the aqueous extract of Cleome arabica L (CAAE).

Methods: The acute toxicity of CAAE was evaluated at doses of 500, 1000, or 2000 mg/kg. Parallelly, body weight, signs of toxicity, and/or mortality were observed for 14 days. The effect of oral administration of Cleome arabica aqueous extract (CAAE) at a dose of 100 mg/kg on glycemia was performed in normal and diabetic rats. Additionally, histopathological structure of the liver, phytochemical screening and in vitro antioxidant activity were studied.

Results: The acute toxicity test revealed that all treated rats survived, and no change in body weight was observed. The results demonstrated that CAAE exhibited a significant antihyperglycemic effect in diabetic rats. Furthermore, the plant extract ameliorated the liver histology in diabetic rats with a concomitant antioxidant activity.

Conclusion: This study shows that Cleome arabica is partly safe, and its LD50 seems to be greater than 5000 mg/kg. Cleome Arabica has a favorable effect against diabetes, which could be due to the presence of numerous secondary metabolites and by the protection of hepatocytes.

Cite this article as:

Amssayef Ayoub and Eddouks Mohamed*, Acute Toxicity Analysis and Antidiabetic Effect of the Moroccan Spider Flower (Cleome Arabica L.) in Normal and Sreptozotocin-Induced Diabetic Rats, Endocrine, Metabolic & Immune Disorders - Drug Targets 2021; 21 (8) . https://dx.doi.org/10.2174/1871530320666201007150438