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Current Organocatalysis

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Review Article

Asymmetric Organocatalyzed Warfarin Synthesis in Aqueous and Nonaqueous Media: A Discussion in the Era of COVID-19 Pandemic

Author(s): Anirban Mondal and Kartick C. Bhowmick*

Volume 8, Issue 1, 2021

Published on: 09 September, 2020

Page: [109 - 125] Pages: 17

DOI: 10.2174/2213337207999200909115215

Price: $65

Abstract

The recent widespread infection of COVID-19 in the entire world has created a pandemic situation with a serious health challenge to mankind. Numerous incidents of cardiovascular diseases were found among COVID-19 patients with a significantly high morbidity rate. Medication with several anticoagulant or blood thinner drugs are being performed on COVID-19 patients with atrial fibrillation and cardiovascular ailments to minimize the incidence of death. Warfarin is a widely used anticoagulant and cardiovascular drug prescribed as its sodium salt. S-Enantiomer is two to five times more active than R-enantiomer as an anticoagulant. Synthesis of enantiomerically pure warfarin is thus a rational and extremely important task. Organocatalyzed synthetic strategies may be considered as important avenues to produce optically pure warfarin in comparison to biocatalysis and chiral metal complex catalysis. Herein, a comprehensive review of the asymmetric organocatalyzed synthesis of warfarin catalyzed by diamine based organocatalysts, amino acidbased organocatalysts, quinine based organocatalysts, and proline derived organocatalysts in both aqueous and non-aqueous media has been discussed.

Keywords: COVID-19, cardiovascular diseases, anticoagulant, organocatalysis, warfarin synthesis, michael reaction, aqueous media, non-aqueous media.

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