Login Register Cart 0
Generic placeholder image

Current Respiratory Medicine Reviews

Editor-in-Chief

ISSN (Print): 1573-398X
ISSN (Online): 1875-6387

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Asthma-COPD Overlap (ACO) among Adult-onset Asthma Patients

Author(s): Daniel Maranatha* and Nurkristi Permatasari Amin

Volume 16, Issue 1, 2020

Page: [66 - 70] Pages: 5

DOI: 10.2174/1573398X16999200629002849

Price: $65

Abstract

Background: Asthma and asthma-COPD overlap (ACO) are heterogeneous airway obstruction. This study aims to differentiate ACO and adult-onset asthma based on pulmonary function tests, smoking history, and atopic status.

Method: This cross-sectional study of adult-onset asthma evaluated characteristics, such as bronchodilator reversibility test, the skin prick test, total serum IgE, and serum IL-13 levels of asthma patients who were current/former smokers with a smoking history of <10 packs-year and ≥10 packs-year and who also had taken FEV1 / FVC <0.7 post-bronchodilator.

Results: The data of 30 subjects were analyzed and divided into two groups (23 asthma and 7 ACO subjects). The ACO patients were older compared to asthma patients (63.4 ± 4.7 vs. 53.7 ± 7.7, p = 0.004). A higher percentage of men was found in ACO than in asthma (85.7% vs. 21.7%, p = 0.004). There was a difference in the cumulative number of cigarettes consumed in patients with ACO and asthma (19.4 ± 6.4 vs. 7.2 ± 2.6, p = 0.014). The ratio of FEV1 / FVC post-bronchodilator in ACO patients was significantly lower than in asthma patients (57.3 ± 6.9 vs. 65.5 ± 8.8, p = 0.033). There was no difference in the duration of the disease between ACO and asthma (7.2 ± 6.1 vs. 6.1 ± 5.5, p = 0.535).

Conclusion: Differences were seen in the number of cigarettes consumed and the ratio of FEV1/FVC in ACO and adult-onset asthma patients. The cumulative number of cigarettes consumed could be a distinguishing characteristic between ACO and asthma.

Keywords: Asthma-chronic, obstructive, pulmonary disease, overlap syndrome, spirometry, smoking.

« Previous
Graphical Abstract

[1]
Global Initiative for Asthma. Diagnosis of asthma, COPD, and asthma-COPD overlap (ACOS). A joint project of GINA and GOLD. Available from: www. ginasthma.org
[2]
Postma DS, Rabe KF. The asthma-COPD overlap syndrome. N Engl J Med 2015; 373(13): 1241-9.
[http://dx.doi.org/10.1056/NEJMra1411863] [PMID: 26398072]
[3]
Barrecheguren M, Esquinas C, Miravitlles M. The asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS): opportunities and challenges. Curr Opin Pulm Med 2015; 21(1): 74-9.
[http://dx.doi.org/10.1097/MCP.0000000000000118] [PMID: 25405671]
[4]
Wurst KE, Kelly-Reif K, Bushnell GA, Pascoe S, Barnes N. Understanding asthma-chronic obstructive pulmonary disease overlap syndrome. Respir Med 2016; 110: 1-11.
[http://dx.doi.org/10.1016/j.rmed.2015.10.004] [PMID: 26525374]
[5]
Cosio BG, Dacal D. Perez de Llano L. Asthma-COPD overlap: identification and optimal treatment. Ther Adv Respir Dis 2018; 12: 1-11.
[http://dx.doi.org/10.1177/1753466618805662]
[6]
Cataldo D, Corhay JL, Derom E, et al. A Belgian survey on the diagnosis of asthma-COPD overlap syndrome. Int J Chron Obstruct Pulmon Dis 2017; 12: 601-13.
[http://dx.doi.org/10.2147/COPD.S124459] [PMID: 28243078]
[7]
Legend Max TM. ELISA Kit Human IL-13 20178-9; [accessed: March 7, 2017]. .Available from: https://www.biolegend.com/Files/Images/media_assets/pro_detail/datasheets/435207_R8_Human_IL-13.pdf
[8]
Agondi RC, Andrade MC, Takejima P, Aun MV, Kalil J, Giavina-Bianchi P. Atopy is associated with age at asthma onset in elderly patients. J Allergy Clin Immunol Pract 2018; 6(3): 865-71.
[http://dx.doi.org/10.1016/j.jaip.2017.10.028] [PMID: 29175370]
[9]
Wang YC, Jaakkola MS, Lajunen TK, Lai CH, Jaakkola JJK. Asthma-COPD Overlap Syndrome among subjects with newly diagnosed adult-onset asthma. Allergy 2018; 73(7): 1554-7.
[http://dx.doi.org/10.1111/all.13459] [PMID: 29663422]
[10]
Sin DD, Miravitlles M, Mannino DM, et al. What is asthma-COPD overlap syndrome? Towards a consensus definition from a round table discussion. Eur Respir J 2016; 48(3): 664-73.
[http://dx.doi.org/10.1183/13993003.00436-2016] [PMID: 27338195]
[11]
Lee WS, Yoo HJ, Park JM, et al. Early diagnosis and management of chronic obstructive pulmonary disease. Tuberc Respir Dis (Seoul) 2011; 70: 293-300.
[http://dx.doi.org/10.4046/trd.2011.70.4.293]
[12]
Kiljander T, Helin T, Venho K, Jaakkola A, Lehtimäki L. Prevalence of asthma-COPD overlap syndrome among primary care asthmatics with a smoking history: a cross-sectional study. NPJ Prim Care Respir Med 2015; 25: 15047.
[http://dx.doi.org/10.1038/npjpcrm.2015.47] [PMID: 26182124]
[13]
de Marco R, Pesce G, Marcon A, et al. The coexistence of asthma and chronic obstructive pulmonary disease (COPD): prevalence and risk factors in young, middle-aged and elderly people from the general population. PLoS One 2013; 8(5): e62985
[http://dx.doi.org/10.1371/journal.pone.0062985] [PMID: 23675448]
[14]
Lange P. Persistent airway obstruction in asthma. Am J Respir Crit Care Med 2013; 187(1): 1-2.
[http://dx.doi.org/10.1164/rccm.201211-1966ED] [PMID: 23281346]
[15]
Aanerud M, Carsin AE, Sunyer J, et al. Interaction between asthma and smoking increases the risk of adult airway obstruction. Eur Respir J 2015; 45(3): 635-43.
[http://dx.doi.org/10.1183/09031936.00055514] [PMID: 25431272]
[16]
Thomson NC, Chaudhuri R, Livingston E. Asthma and cigarette smoking. Eur Respir J 2004; 24(5): 822-33.
[http://dx.doi.org/10.1183/09031936.04.00039004] [PMID: 15516679]
[17]
Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention; update 2019.[accessed: June 27, 2019] Available from: www.ginasthma.org
[18]
Perret JL, Dharmage SC, Matheson MC, et al. The interplay between the effects of lifetime asthma, smoking, and atopy on fixed airflow obstruction in middle age. Am J Respir Crit Care Med 2013; 187(1): 42-8.
[http://dx.doi.org/10.1164/rccm.201205-0788OC] [PMID: 23155143]
[19]
de Llano LP, Cosío BG, Iglesias A, et al. Mixed Th2 and non-Th2 inflammatory pattern in the asthma-COPD overlap: a network approach. Int J Chron Obstruct Pulmon Dis 2018; 13: 591-601.
[http://dx.doi.org/10.2147/COPD.S153694] [PMID: 29483774]

Rights & Permissions Print Cite
Article Metrics
15
© 2024 Bentham Science Publishers | Privacy Policy