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Protein & Peptide Letters

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ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

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Letter to the Editor

Novel Insights on the Role of the Human Sperm Proteome

Author(s): Rossella Cannarella, Rosita A. Condorelli*, Aldo E. Calogero and Sandro La Vignera

Volume 27, Issue 12, 2020

Page: [1181 - 1185] Pages: 5

DOI: 10.2174/0929866527666200505215921

Price: $65

Abstract

The spermatozoon has classically been seen only as a paternal DNA transporter into the oocyte, thus underestimating the entire contribution of the male gamete to the embryo development. The advancement of the research supports that not only the sperm genome, but the entire sperm transcriptome and proteome carry crucial information for fertilization and embryo development.

Altogether, 6871 proteins have been reported in spermatozoa so far. Their functional analysis has recently addressed to the sperm proteome a role in fertilization, preimplantation embryo development and paternal epigenetic inheritance. Targeted analysis of human spermatozoa is warranted to compile an evidence-based list of sperm-carried molecular targets in infertile patients.

Keywords: Sperm proteome, fertilization, embryo development, epigenetic, gene ontology, male infertility.

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Graphical Abstract

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