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Infectious Disorders - Drug Targets

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ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

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Research Article

Bacteriological Profile and Antibiotic Resistance in Patients with Urinary Tract Infection in Tertiary Care Teaching Hospital in Western Rajasthan India

Author(s): Mahadev Meena*, Naveen Kishoria, Durga Shankar Meena and Vikram Singh Sonwal

Volume 21, Issue 2, 2021

Published on: 18 March, 2020

Page: [257 - 261] Pages: 5

DOI: 10.2174/1871526520666200318110447

Price: $65

Abstract

Background: Urinary tract infection (UTI) is one of the most common bacterial infection with a significant economic burden on the health care system in developing countries like India. Rising antibiotic resistance is a matter of great concern.

Aims: The aim of this study was to determine the bacteriological profile and antibiotic resistance pattern in patients with UTI in Tertiary Care Hospital in western Rajasthan India.

Settings and Design: A cross-sectional, descriptive study was conducted from December 2017 to November 2018 at MDM hospital S.N. medical college, Jodhpur in Western Rajasthan.

Materials and Methods: All the patients with symptoms of urinary tract infection presented in the outpatient unit or developed symptoms within 48 hr of hospitalisation were included in the study. Only those patients with significant bacteriuria (105 colony-forming units /ml) were included.

Results: A total of 119 (55.34%) positive urine cultures were identified. The most common bacteria isolated in the urine sample was E. coli (37.2%) followed by Klebsiella pneumonia (10.2%), Enterococci spp. (3.3%), and Pseudomonas spp. (1.9%). Gram-negative bacteria represented 92.44% of the isolates. E. coli showed maximum resistance towards co-trimoxazole (78.75%) followed by cefuroxime (77.5%) and ciprofloxacin (72.5%). Klebsiella pneumoniae showed the highest resistance against co-trimoxazole (23.75%) and ciprofloxacin (23.75%).

Conclusion: The present study gives an idea about the common trend of antibiotic resistance of uropathogens in this region. The findings in our study will help in the formulation of antibiotic policy and the determination of empirical treatment of UTI in this region.

Keywords: Urinary Tract Infections, drug resistance, antibiotics, E. coli, Klebsiella pneumonia, Pseudomonas spp.

Graphical Abstract

[1]
Gupta, K. Emerging antibiotic resistance in urinary tract pathogens. Infect. Dis. Clin. North Am., 2003, 17(2), 243-259.
[http://dx.doi.org/10.1016/S0891-5520(03)00006-0] [PMID: 12848469]
[2]
Akoachere, J.F.; Yvonne, S.; Akum, N.H.; Seraphine, E.N. Etiologic profile and antimicrobial susceptibility of community-acquired urinary tract infection in two Cameroonian towns. BMC Res. Notes, 2012, 5, 219.
[http://dx.doi.org/10.1186/1756-0500-5-219] [PMID: 22564344]
[3]
Krumperman, P.H. Multiple antibiotic resistance indexing of Escherichia coli to identify high-risk sources of fecal contamination of foods. Appl. Environ. Microbiol., 1983, 46(1), 165-170.
[http://dx.doi.org/10.1128/AEM.46.1.165-170.1983] [PMID: 6351743]
[4]
Prakash, D.; Saxena, R.S. Distribution and antimicrobial susceptibility pattern of bacterial pathogens causing urinary tract infection in urban community of meerut city, India. ISRN Microbiol., 2013, 2013, 749629.
[http://dx.doi.org/10.1155/2013/749629] [PMID: 24288649]
[5]
Kaur, N.; Sharma, S.; Malhotra, S.; Madan, P.; Hans, C. Urinary tract infection: aetiology and antimicrobial resistance pattern in infants from a tertiary care hospital in northern India. J. Clin. Diagn. Res., 2014, 8(10), DC01-DC03.
[http://dx.doi.org/10.7860/JCDR/2014/8772.4919] [PMID: 25478339]
[6]
Akram, M.; Shahid, M.; Khan, A.U. Etiology and antibiotic resistance patterns of community-acquired urinary tract infections in J N M C Hospital Aligarh, India. Ann. Clin. Microbiol. Antimicrob., 2007, 6, 4.
[http://dx.doi.org/10.1186/1476-0711-6-4] [PMID: 17378940]
[7]
Kothari, A.; Sagar, V. Antibiotic resistance in pathogens causing community-acquired urinary tract infections in India: a multicenter study. J. Infect. Dev. Ctries., 2008, 2(5), 354-358.
[http://dx.doi.org/10.3855/jidc.196] [PMID: 19745502]
[8]
Hasan, A.S.; Nair, D.; Kaur, J.; Baweja, G.; Deb, M.; Aggarwal, P. Resistance patterns of urinary isolates in a tertiary Indian hospital. J. Ayub Med. Coll. Abbottabad, 2007, 19(1), 39-41.
[PMID: 17867478]
[9]
Bahadin, J.; Teo, S.S.; Mathew, S. Aetiology of community-acquired urinary tract infection and antimicrobial susceptibility patterns of uropathogens isolated. Singapore Med. J., 2011, 52(6), 415-420.
[PMID: 21731993]
[10]
PiA(c)boji, J.G.; Koulla-Shiro, S.; Ngassam, P.; Adiogo, D.; Njine, T.; Ndumbe, P. Antimicrobial resistance of Gram-negative bacilli isolates from inpatients and outpatients at Yaounde Central Hospital, Cameroon. Int. J. Infect. Dis., 2004, 8(3), 147-154.
[http://dx.doi.org/10.1016/j.ijid.2004.01.001] [PMID: 15109589]
[11]
Lewis, D.A.; Gumede, L.Y.; van der Hoven, L.A.; de Gita, G.N.; de Kock, E.J.; de Lange, T.; Maseko, V.; Kekana, V.; Smuts, F.P.; Perovic, O. Antimicrobial susceptibility of organisms causing community-acquired urinary tract infections in Gauteng Province, South Africa. S. Afr. Med. J., 2013, 103(6), 377-381.
[http://dx.doi.org/10.7196/SAMJ.6722] [PMID: 23725955]
[12]
Odongo, C.O.; Anywar, D.A.; Luryamamoi, K.; Odongo, P. Antibiograms from community-acquired uropathogens in Gulu, northern Uganda- a cross-sectional study. BMC Infect. Dis., 2013, 13, 193.
[http://dx.doi.org/10.1186/1471-2334-13-193] [PMID: 23627344]
[13]
Kyabaggu, D.; Ejobi, F.; Olila, D. The sensitivities to first-line antibiotic therapy of the common urinary tract bacterial infections detected in urine samples at a hospital in metropolitan Kampala (Uganda). Afr. Health Sci., 2007, 7(4), 214-222.
[PMID: 21499486]
[14]
Mwaka, A.D.; Mayanja-Kizza, H.; Kigonya, E.; Kaddu-Mulindwa, D. Bacteriuria among adult non-pregnant women attending Mulago hospital assessment centre in Uganda. Afr. Health Sci., 2011, 11(2), 182-189.
[PMID: 21857848]
[15]
Patwardhan, V.; Kumar, D.; Goel, V.; Singh, S. Changing prevalence and antibiotic drug resistance pattern of pathogens seen in community-acquired pediatric urinary tract infections at a tertiary care hospital of North India. J. Lab. Physicians, 2017, 9(4), 264-268.
[http://dx.doi.org/10.4103/JLP.JLP_149_16] [PMID: 28966488]
[16]
Gupta, K.; Grigoryan, L.; Trautner, B. Urinary Tract Infection. Ann. Intern. Med., 2017, 167(7), ITC49-ITC64.
[http://dx.doi.org/10.7326/AITC201710030] [PMID: 28973215]
[17]
Stamm, W.E.; Norrby, S.R. Urinary tract infections: disease panorama and challenges. J. Infect. Dis., 2001, 183(Suppl. 1), S1-S4.
[http://dx.doi.org/10.1086/318850] [PMID: 11171002]
[18]
Gupta, K.; Hooton, T.M.; Stamm, W.E. Increasing antimicrobial resistance and the management of uncomplicated community-acquired urinary tract infections. Ann. Intern. Med., 2001, 135(1), 41-50.
[http://dx.doi.org/10.7326/0003-4819-135-1-200107030-00012] [PMID: 11434731]
[19]
Patel, R.B.; Welling, P.G. Clinical pharmacokinetics of co-trimoxazole (sulfamethoxazole-trimethoprim). Clin. Pharmacokinet., 1980, 5(5), 405-423.
[http://dx.doi.org/10.2165/00003088-198005050-00001] [PMID: 7408366]
[20]
Drago, L.; De Vecchi, E.; Mombelli, B.; Nicola, L.; Valli, M.; Gismondo, M.R. Activity of levofloxacin and ciprofloxacin against urinary pathogens. J. Antimicrob. Chemother., 2001, 48(1), 37-45.
[http://dx.doi.org/10.1093/jac/48.1.37] [PMID: 11418511]

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