Inflammatory Markers in Cardiovascular Disease; Lessons Learned and Future Perspectives

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Author(s): Dimitrios Patoulias, Konstantinos Stavropoulos, Konstantinos Imprialos, Vasilios Athyros, Haris Grassos, Michael Doumas, Charles Faselis*.

Journal Name: Current Vascular Pharmacology

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Background: Cardiovascular disease (CVD) still remains the leading cause of morbidity and mortality worldwide. It is now established that inflammation plays a crucial role in atherosclerosis and atherothrombosis, and thus, it is closely linked to cardiovascular disease.

Objective: The aim of the present review is to summarize and critically appraise the most relevant evidence regarding the potential use of inflammatory markers in the field of CVD.

Method: We conducted a comprehensive research of the relevant literature, searching MEDLINE from its inception until November 2018, primarily for meta-analyses, randomized controlled trials and observational studies.

Results: Established markers of inflammation, mainly C-reactive protein, have yielded significant results both for primary and secondary prevention of CVD. Newer markers, such as lipoprotein-associated phospholipase A2, lectin-like oxidized low-density lipoprotein receptor-1, cytokines, myeloperoxidase, cell adhesion molecules, matrix metalloproteinases, and the CD40/CD40 ligand system, have been largely evaluated in human studies, enrolling both individuals from the general population and patients with established CVD. Some markers have yielded conflicting results; however, other are now recognized not only as promising biomarkers of CVD, but also as potential therapeutic targets, establishing the role of anti-inflammatory and pleiotropic drugs in CVD.

Conclusion: There is significant evidence regarding the role of consolidated and novel inflammatory markers in the field of diagnosis and prognosis of CVD. However, multimarker model assessment, validation of cut-off values and cost-effectiveness analyses are required, in order for those markers to be integrated into daily clinical practice.

Keywords: inflammation, cardiovascular disease, atherosclerosis, biomarker, atherothrombosis, MEDLINE

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(E-pub Ahead of Print)
DOI: 10.2174/1570161118666200318104434
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