Login Register Cart 0
Generic placeholder image

Current Drug Discovery Technologies

Editor-in-Chief

ISSN (Print): 1570-1638
ISSN (Online): 1875-6220

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

Traditional Aspects of Sciatic Pain Management and Allied Therapies from Persian Medical Reports

Author(s): Ramin Ansari, Amirhossein Dadbakhsh, Fatemeh Hasani, Fatemeh Hosseinzadeh, Zohreh Abolhassanzadeh and Mohammad M. Zarshenas*

Volume 18, Issue 2, 2021

Published on: 16 March, 2020

Page: [194 - 206] Pages: 13

DOI: 10.2174/1570163817666200316112120

Price: $65

Abstract

Sciatica is a common back pain caused by irritation of the sciatic nerve. Current pharmacologic therapies have proven inadequate for many patients with sciatic pain. On the other hand, there is a globally increasing demand for the use and administration of natural medicaments for this disorder. Traditional Persian Medicine (TPM) is a school of medicine and a medicinal plant-based resource for clinical studies put forward by Persian scholars. The aim of the present study is to gather and study the effectiveness of all medicinal plants from five main Persian pharmacopeias. Furthermore, different databases such as PubMed and Scopus have been checked to derive relevant activities for these plants. In all, 99 medicinal plants related to 42 families have been authenticated. Asteraceae and Apiaceae were the most frequent families and roots and seeds were the most reported botanical parts. The employed routes of administration were oral (54%), topical (33%) and rectal (13%). Anti-inflammatory, analgesic activity and antinociceptive properties of medicines are known as some main mechanisms to manage sciatic pain. These functions are possessed by 30%, 15%, and 15% of the studied plants, respectively. Medicaments that can be introduced as lead agents for further investigation are Zingiber officinale Roscoe, Olea europaea L., Strychnos nux-vomica L and Artemisia vulgaris L which showed all of these properties in previous studies. Hence, conducting adducible clinical trials using these lead agents may lead to novel drugs with lesser undesirable and much more therapeutic effects on controlling sciatic pain.

Keywords: Sciatic pain, traditional medicine, analgesic, pharmacopeia, herbal, sciatica.

[1]
Jahan N. Eksir-e-Azam. Tehran: Institute for Islamic and Complementary Medicine 2009; pp. 704-53.
[2]
Alhavi fi teb MZ R.. Translated to Persian by: Tabatabai SM Tehran: Nashre Sherkate Darusazie Alhavi. 1990.
[3]
Sina AI. Al-Qanun fi al-tibb2005
[4]
Attar H. Ikhtiyarat-e-badiyee. Lucknow, India Munshi Nawal Kishore 1888; 1370: 381.
[5]
Tunakabuni M. Tuhfat al-Mu’minin. Tehran: Research Center of Traditional Medicine, Shahid Beheshti University of Medical Sciences. Nashre Shahr Press 2007.
[6]
Shirazi A. Makhzan Al-adviyah (the Storehouse of medicaments). Tehran, Iran: Tehran University of Medical Sciences 2009.
[7]
Ghahreman A, Okhovvat AR. Matching the old medicinal plant names with scientific terminology. University of Tehran Press 2010.
[8]
Khare CP. Indian medicinal plants: an illustrated dictionary. Springer Science & Business Media 2008.
[9]
Kim H, Han T-H, Lee S-G. Anti-inflammatory activity of a water extract of Acorus calamus L. leaves on keratinocyte HaCaT cells. J Ethnopharmacol 2009; 122(1): 149-56.
[http://dx.doi.org/10.1016/j.jep.2008.12.011] [PMID: 19146941]
[10]
Khurana N, Jain PK, Pounikar Y, Sharma N. Pharmacological evaluation of rhizomes of acorus calamus for analgesic activity. Int J Pharm Pharm Sci 2015; 7(1): 1.
[11]
Jayanthi M, Dhar M, Jayanthi M. Anti-inflammatory effects of Allium sativum (Garlic) in experimental Rats. Biomedicine (Taipei) 2011; 31(1)
[12]
Mencherini T, Cau A, Bianco G, Della Loggia R, Aquino RP, Autore G. An extract of Apium graveolens var. dulce leaves: structure of the major constituent, apiin, and its anti-inflammatory properties. J Pharm Pharmacol 2007; 59(6): 891-7.
[http://dx.doi.org/10.1211/jpp.59.6.0016] [PMID: 17637182]
[13]
Ramezani M, Nasri S, Yassa N. Antinociceptive and anti-inflammatory effects of isolated fractions from Apium graveolens seeds in mice. Pharm Biol 2009; 47(8): 740-3.
[http://dx.doi.org/10.1080/13880200902939283]
[14]
Panahi Y, Dadjo Y, Pishgoo B, Akbari A, Sahebkar A. Clinical evaluation of the anti-inflammatory effects of Heracleum persicum fruits. Comp Clin Pathol 2015; 24(4): 971-4.
[http://dx.doi.org/10.1007/s00580-015-2082-3]
[15]
Hajhashemi V, Sajjadi SE, Heshmati M. Anti-inflammatory and analgesic properties of Heracleum persicum essential oil and hydroalcoholic extract in animal models. J Ethnopharmacol 2009; 124(3): 475-80.
[http://dx.doi.org/10.1016/j.jep.2009.05.012] [PMID: 19467316]
[16]
Benson KF, Newman RA, Jensen GS. Antioxidant, anti-inflammatory, anti-apoptotic, and skin regenerative properties of an Aloe vera-based extract of Nerium oleander leaves (nae-8.(®)) Clin Cosmet Investig Dermatol 2015; 8: 239-48.
[PMID: 26005354]
[17]
de Almeida ABA, Sánchez-Hidalgo M, Martín AR, et al. Anti-inflammatory intestinal activity of Arctium lappa L. (Asteraceae) in TNBS colitis model. J Ethnopharmacol 2013; 146(1): 300-10.
[http://dx.doi.org/10.1016/j.jep.2012.12.048] [PMID: 23313393]
[18]
Afsar S, Kumar KR, Gopal JV, Raveesha P. Assessment of antiinflammatory activity of Artemisia vulgaris leaves by cotton pellet granuloma method in Wistar albino rats. journal of pharmacy research 2013; 7(6): 463-7.
[19]
Pires JM, Mendes FR, Negri G, Duarte-Almeida JM, Carlini EA. Antinociceptive peripheral effect of Achillea millefolium L. and Artemisia vulgaris L.: both plants known popularly by brand names of analgesic drugs. Phytother Res 2009; 23(2): 212-9.
[http://dx.doi.org/10.1002/ptr.2589] [PMID: 18844327]
[20]
Parente LML, Júnior L, de Souza R, et al. Assessment of anti-inflammatory activity of Artemisia vulgaris leaves by cotton pellet granuloma method in Wistar albino rats. J Pharm Res 2012; 7(6): 463-7.
[21]
Shahidi S, Mahmoodi M, Farahmandlou N. Antinociceptive properties of hydro-alcoholic extract of calendula officinalis in rat. Basic Clin Neurosci 2012; 3(5): 45-8.
[22]
Fallahzadeh A, Mohammadi S. An Investigation of the antinociceptive and anti-inflammatory effects of hydroalcoholic extract of inula helenium on male rats. Majallah-i Danishgah-i Ulum-i Pizishki-i Babul 2016; 18(12): 57-63.
[23]
Chandrasenan P, Anjumol V, Neethu M, Selvaraj R, Anandan V, Jacob GM. Cytoprotective and antiinflammatory effect of polyphenolic fraction from Red cabbage (Brassica oleracea Linn var. capitata f rubra) in experimentally induced ulcerative colitis. J Appl Pharm Sci 2016; 6(1): 137-46.
[http://dx.doi.org/10.7324/JAPS.2016.600122]
[24]
Hasan M, Al-Mahamud R, Rahman S, Ahmad I, Rahmatullah M. A preliminary report on antihyperglycemic and analgesic properties of methanol extract of Brassica oleracea L. var. italica sprouts. World J Pharm Pharm Sci 2015; 4(09): 225-34.
[25]
Su S, Hua Y, Wang Y, et al. Evaluation of the anti-inflammatory and analgesic properties of individual and combined extracts from Commiphora myrrha, and Boswellia carterii. J Ethnopharmacol 2012; 139(2): 649-56.
[http://dx.doi.org/10.1016/j.jep.2011.12.013] [PMID: 22178177]
[26]
El Azhary K, Tahiri Jouti N, El Khachibi M, et al. Anti-inflammatory potential of Capparis spinosa L. in vivo in mice through inhibition of cell infiltration and cytokine gene expression. BMC Complement Altern Med 2017; 17(1): 81.
[http://dx.doi.org/10.1186/s12906-017-1569-7] [PMID: 28143472]
[27]
Parimala S, Shashidhar G, Sridevi C, Jyothi V, Suthakaran R. Anti-inflammatory activity of Celastrus paniculatus seeds. Int J Pharm Tech Res 2009; 1: 1326-9.
[28]
Ahmad F, Khan RA, Rasheed S. Preliminary screening of methanolic extracts of Celastrus paniculatus and Tecomella undulata for analgesic and anti-inflammatory activities. J Ethnopharmacol 1994; 42(3): 193-8.
[http://dx.doi.org/10.1016/0378-8741(94)90085-X] [PMID: 7934089]
[29]
Marzouk B, Marzouk Z, Fenina N, Bouraoui A, Aouni M. Anti-inflammatory and analgesic activities of Tunisian Citrullus colocynthis Schrad. immature fruit and seed organic extracts. Eur Rev Med Pharmacol Sci 2011; 15(6): 665-72.
[PMID: 21796871]
[30]
Marzouk B, Haloui E, Fenina N, Aouni M, Marzouk Z. Comparative evaluation of the analgesic activity of several populations of Tunisian Citrullus colocynthis Schrad. immature fruits. J Appl Pharm Sci 2013; 3(5): 22.
[31]
Vouldoukis I, Lacan D, Kamate C, et al. Antioxidant and anti-inflammatory properties of a Cucumis melo LC. extract rich in superoxide dismutase activity. J Ethnopharmacol 2004; 94(1): 67-75.
[http://dx.doi.org/10.1016/j.jep.2004.04.023] [PMID: 15261965]
[32]
Yesilada E, Tanaka S, Tabata M, Sezik E. Antiinflammatory effects of the fruit juice of Ecballium elaterium on edemas in mice. Phytother Res 1989; 3(2): 75-6.
[http://dx.doi.org/10.1002/ptr.2650030210]
[33]
Agil MA, Risco S, Miro M, Navarro M, Ocete M, Jiménez J. Analgesic and antipyretic effects of Ecballium elaterium (L.) A. Richard. Extract in rodents. Phytother Res 1995; 9(2): 135-8.
[http://dx.doi.org/10.1002/ptr.2650090211]
[34]
Zdunić G, Gođevac D, Milenković M, et al. Evaluation of Hypericum perforatum oil extracts for an antiinflammatory and gastroprotective activity in rats. Phytother Res 2009; 23(11): 1559-64.
[http://dx.doi.org/10.1002/ptr.2809] [PMID: 19367676]
[35]
Zhu SJ, Hu R, Jia YR, Guo WY, Zhu BSKSJ, Ku BS. Antinociceptive effect of extraction of Hypericum perforatum Linn and vitamin Bs on the pain caused by formaldehyde in mice. Zhongguo Linchuang Kangfu 2004; (8): 68.
[36]
Kumar V, Singh P, Bhattacharya S. Anti-inflammatory and analgesic activity of Indian Hypericum perforatum L 2001.
[37]
Hosseinzadeh H, Ramezani M, Salmani G. Antinociceptive, anti-inflammatory and acute toxicity effects of Zataria multiflora Boiss extracts in mice and rats. J Ethnopharmacol 2000; 73(3): 379-85.
[http://dx.doi.org/10.1016/S0378-8741(00)00238-5] [PMID: 11090990]
[38]
Ramezani M, Hosseinzadeh H, Samizadeh S. Antinociceptive effects of Zataria multiflora Boiss fractions in mice. J Ethnopharmacol 2004; 91(1): 167-70.
[http://dx.doi.org/10.1016/j.jep.2003.12.016] [PMID: 15036484]
[39]
Hajhashemi V, Zolfaghari B, Yousefi A. Antinociceptive and anti-inflammatory activities of Satureja hortensis seed essential oil, hydroalcoholic and polyphenolic extracts in animal models. Med Princ Pract 2012; 21(2): 178-82.
[http://dx.doi.org/10.1159/000333555] [PMID: 22095089]
[40]
Chen J, Wang X, Qu YG, et al. Analgesic and anti-inflammatory activity and pharmacokinetics of alkaloids from seeds of Strychnos nux-vomica after transdermal administration: effect of changes in alkaloid composition. J Ethnopharmacol 2012; 139(1): 181-8.
[http://dx.doi.org/10.1016/j.jep.2011.10.038] [PMID: 22094056]
[41]
Cai B, Nagasawa T, Kadota S, Hattori M, Namba T, Kuraishi Y. Processing of nux vomica. VII. Antinociceptive effects of crude alkaloids from the processed and unprocessed seeds of Strychnos nux-vomica in mice. Biol Pharm Bull 1996; 19(1): 127-31.
[http://dx.doi.org/10.1248/bpb.19.127] [PMID: 8820924]
[42]
Özdemir H, Yaren B, Oto G. Antinociceptive activity of aqueous extract of Lepidium sativum L. in mice. East J Med 2015; 20(3): 131-5.
[43]
Hamiad M, Numan IT, Hassan AF. Evaluation of anti-inflammatory effect of ethyl acetate and methanol extracts of loranthus europaeus in experimental models of acute inflammation in rats. Int J Pharm Sci Rev Res 2013; 23: 170-4.
[44]
Sleiman N, Daher C. Malva sylvestris water extract: a potential anti-inflammatory and anti-ulcerogenic remedy. Planta Med 2009; 75(09): PH10.
[http://dx.doi.org/10.1055/s-0029-1234727]
[45]
Esteves PF, Sato A, Esquibel MA, de Campos-Buzzi F, Meira AV, Cechinel-Filho V. Antinociceptive activity of Malva sylvestris L. Lat Am J Pharm 2009; 28(3): 454-6.
[46]
Akacha M, Lahbib K, Daami-Remadi M, Boughanmi NG. Antibacterial, antifungal and anti-inflammatory activities of Melia azedarach ethanolic leaf extract. Bangladesh J Pharmacol 2016; 11(3): 666-74.
[http://dx.doi.org/10.3329/bjp.v11i3.27000]
[47]
Samdani V, Rana A. Evaluation of hydroalcoholic extract of Melia azedarach Linn roots for analgesic and anti-inflammatory activity. Int J Phytomed 2010; 2(3)
[48]
Satya V, Paridhavi M. Evaluation of anti-inflammatory activity of Anamirta cocculus Linn. fruit. Int J Res Pharm Sci 2016; 4(1): 30-5.
[49]
Kumar MP, Joshi SD, Kulkarni V, Savant C. Phytochemical screening and evaluation of analgesic, anti-inflammatory activities of Peganum harmala Linn., seeds in rodents. J App Pharm Sci 2015; 5(5): 052-55.
[50]
Monsef HR, Ghobadi A, Iranshahi M, Abdollahi M. Antinociceptive effects of Peganum harmala L. alkaloid extract on mouse formalin test. J Pharm Pharm Sci 2004; 7(1): 65-9.
[PMID: 15144736]
[51]
Sahranavard S, Kamalinejad M, Faizi M. Evaluation of anti-inflammatory and anti-nociceptive effects of defatted fruit extract of Olea europaea. Iran J Pharm Res 2014; 13(Suppl.): 119-23.
[PMID: 24711837]
[52]
Nieto FR, Cobos EJ, Entrena JM, Parra A, García-Granados A, Baeyens JM. Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea. J Nat Prod 2013; 76(4): 737-40.
[http://dx.doi.org/10.1021/np300783a] [PMID: 23540838]
[53]
Ezeja M, Samuel OS, Omeh Y, Chibiko C. Analgesic and antioxidant activities of the methanolic extract of Operculina turpethum leaves in mice. Int J Basic Clin Pharmacol 2015; 4: 453-7.
[http://dx.doi.org/10.18203/2319-2003.ijbcp20150015]
[54]
Gómez‐Serranillos M, Palomino O, Carretero E, Villar A. Analytical study and analgesic activity of oripavine from Papaver somniferum L. Phytother Res 1998; 12(5): 346-9.
[55]
Makchuchit S, Rattarom R, Itharat A. The anti-allergic and anti-inflammatory effects of Benjakul extract (a Thai traditional medicine), its constituent plants and its some pure constituents using in vitro experiments. Biomed Pharmacother 2017; 89: 1018-26.
[http://dx.doi.org/10.1016/j.biopha.2017.02.066] [PMID: 28292010]
[56]
Jahan I, Akbar P, Khan N, et al. Comparative study of anti-nociceptive activity and phenolic content of the ethanol extracts of Piper nigrum and Piper longum fruits. Int J Pharm Sci Rev Res 2014; 27(27): 47-52.
[57]
Tripathi RK, Bolegave SS, Shetty PA, et al. Efficacy and safety of a polyherbal formulation in hemorrhoids. J Ayurveda Integr Med 2015; 6(4): 225-32.
[http://dx.doi.org/10.4103/0975-9476.172382] [PMID: 26834421]
[58]
Núñez Guillén ME, da Silva Emim JA, Souccar C, Lapa AJ. Analgesic and anti-inflammatory activities of the aqueous extract of Plantago major L. Int J Pharmacol 1997; 35(2): 99-104.
[http://dx.doi.org/10.1076/phbi.35.2.99.13288]
[59]
Tomovic MT, Cupara SM, Popovic-Milenkovic MT, Ljujic BT, Kostic MJ, Jankovic SM. Antioxidant and anti-inflammatory activity of Potentilla reptans L. Acta Pol Pharm 2015; 72(1): 137-45.
[PMID: 25850209]
[60]
Giresha AS, Anitha MG, Dharmappa KK. Phytochemical composition, antioxidant and in-vitro anti-inflammatory activity of ethanol extract of Ruta Graveolens L. leaves. Int J Pharm Pharm Sci 2015; 7(10): 272-6.
[61]
Loonat F, Amabeoku GJ. Antinociceptive, anti-inflammatory and antipyretic activities of the leaf methanol extract of Ruta graveolens L. (Rutaceae) in mice and rats. Afr J Tradit Complement Altern Med 2014; 11(3): 173-81.
[http://dx.doi.org/10.4314/ajtcam.v11i3.25] [PMID: 25371580]
[62]
Khan I, Nisar M, Ebad F, et al. Anti-inflammatory activities of Sieboldogenin from Smilax china Linn.: experimental and computational studies. J Ethnopharmacol 2009; 121(1): 175-7.
[http://dx.doi.org/10.1016/j.jep.2008.10.009] [PMID: 19007873]
[63]
Shu X-S, Gao Z-H, Yang X-L. Anti-inflammatory and anti-nociceptive activities of Smilax china L. aqueous extract. J Ethnopharmacol 2006; 103(3): 327-32.
[http://dx.doi.org/10.1016/j.jep.2005.08.004] [PMID: 16387460]
[64]
Begum S, Saxena B, Goyal M, et al. Study of anti-inflammatory, analgesic and antipyretic activities of seeds of Hyoscyamus niger and isolation of a new coumarinolignan. Fitoterapia 2010; 81(3): 178-84.
[http://dx.doi.org/10.1016/j.fitote.2009.08.024] [PMID: 19720117]
[65]
Gilani AH. In vivo studies on the bronchodilatory and analgesic activities of Hyoscyamus niger and Aspalathus linearis. Lat Am J Pharm 2010; 29(5): 777.
[66]
Hassan N, Karunakaran R, Uma S. Anti-inflammatory effect of Zingiber officinale on Sprague Dawley rats. Asian J Pharm Clin Res 2017; 10(3): 1-3.
[67]
Vendruscolo A, Takaki I, Bersani-Amado L, Dantas J, Bersani-Amado C, Cuman RK. Antiinflammatory and antinociceptive activities of zingiber officinale roscoe essential oil in experimental animal models. Indian J Pharmacol 2006; 38(1): 58.
[http://dx.doi.org/10.4103/0253-7613.19856]
[68]
Ojewole JA. Analgesic, antiinflammatory and hypoglycaemic effects of ethanol extract of Zingiber officinale (Roscoe) rhizomes (Zingiberaceae) in mice and rats. Phytother Res 2006; 20(9): 764-72.
[http://dx.doi.org/10.1002/ptr.1952] [PMID: 16807883]
[69]
García-Lafuente A, Guillamón E, Villares A, Rostagno MA, Martínez JA. Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res 2009; 58(9): 537-52.
[http://dx.doi.org/10.1007/s00011-009-0037-3] [PMID: 19381780]
[70]
Srivastava KC, Mustafa T. Ginger (Zingiber officinale) in rheumatism and musculoskeletal disorders. Med Hypotheses 1992; 39(4): 342-8.
[http://dx.doi.org/10.1016/0306-9877(92)90059-L] [PMID: 1494322]
[71]
Geronikaki AA, Gavalas AM. Antioxidants and inflammatory disease: synthetic and natural antioxidants with anti-inflammatory activity. Comb Chem High Throughput Screen 2006; 9(6): 425-42.
[http://dx.doi.org/10.2174/138620706777698481] [PMID: 16842224]
[72]
Cashman JN. The mechanisms of action of NSAIDs in analgesia. Drugs 1996; 52(5)(Suppl. 5): 13-23.
[http://dx.doi.org/10.2165/00003495-199600525-00004] [PMID: 8922554]
[73]
Yaksh TL. Pharmacology and mechanisms of opioid analgesic activity. Acta Anaesthesiol Scand 1997; 41(1 Pt 2): 94-111.
[http://dx.doi.org/10.1111/j.1399-6576.1997.tb04623.x] [PMID: 9061092]
[74]
Spiegel K, Kalb R, Pasternak GW. Analgesic activity of tricyclic antidepressants. Ann Neurol 1983; 13(4): 462-5.
[http://dx.doi.org/10.1002/ana.410130418] [PMID: 6838179]
[75]
Ebrahimi F, Torbati M, Khoshbakht Z, Khodaie L. Application of herbal rectal suppositories beyond intestinal disorders in Persian medicine. Traditional Med Res 2019; 4(3): 160-72.
[76]
El Gabbas Z, Bezza K, Laadraoui J, et al. Salvia officinalis, rosmarinic and caffeic acids attenuate neuropathic pain and improve function recovery after sciatic nerve chronic constriction in mice. Evidence-Based Complement Altern Med 2019.
[77]
Malek VG, Parvari S, Abbassian A. Low back pain treatments in traditional Iranian medicine. J Pharm Res Int 2019; pp. 1-9.
[http://dx.doi.org/10.9734/jpri/2019/v27i430174]
[78]
Chebbi Mahjoub R, Khemiss M, Dhidah M, Dellaï A, Bouraoui A, Khemiss F. Chloroformic and methanolic extracts of Olea europaea L. leaves present anti-inflammatory and analgesic activities. ISRN Pharmacol 2011.
[79]
Eldahshan OA, Abdel-Daim MM. Phytochemical study, cytotoxic, analgesic, antipyretic and anti-inflammatory activities of Strychnos nux-vomica. Cytotechnology 2015; 67(5): 831-44.
[http://dx.doi.org/10.1007/s10616-014-9723-2] [PMID: 24711053]
[80]
Ashok PK, Upadhyaya K. Evaluation of analgesic and antiinflammatory activities of aerial parts of Artemisia vulgaris L. in experimental animal models. J Biological Active Prod Nat 2013; 3(1): 101-5.
[http://dx.doi.org/10.1080/22311866.2013.782761]

Rights & Permissions Print Cite
Article Metrics
18
1
© 2024 Bentham Science Publishers | Privacy Policy