Abstract
Background: Complicated intra-abdominal infections are still associated with a high risk of an unfavorable outcome. Despite the equal treatment, the mortality rates in some patients’ populations remain significant, especially when the impaired immune response is present.
Aim: The object of this research is to analyze the impact of pro-inflammatory neutrophil CD64 and anti-inflammatory monocyte HLA-DR on the final outcome.
Methods: We have searched in the PubMed database, the literature relating the prognostic value of two biomarkers - nCD64 and mHLA-DR in patients with complicated intra-abdominal infections and/or sepsis.
Results: Eighteen original studies with 2960 patients fulfilled our inclusion criteria. The data about nCD64 that we found was contradictory, whereas low mHLA-DR expression showed good prognostic value.
Conclusion: Our review showed heterogeneous data about nCD64 survival prediction. Further investigations with surgical patients exclusively are needed to evaluate its prognostic value in cIAIs. However, we observed a good prognostic performance of low mHLA-DR expression. After a validation in larger multicentre studies, mHLA-DR could be used as promising prognostic biomarker in cIAIs.
Keywords: Intra-abdominal infections, CD64, HLA-DR, sepsis, outcome, mortality.
Graphical Abstract
[1]
Dellinger EP, Wertz MJ, Meakins Jl, et al. Surgical infection stratification system for intra-abdominal infectionMulticenter trial arch surg 1985; 120(1): 21-9.
[http://dx.doi.org/10.1001/archsurg.1985.01390250015003]
[http://dx.doi.org/10.1001/archsurg.1985.01390250015003]
[2]
Vincent JL, Rello J, Marshall J, et al. International study of the prevalence and outcomes of infection in intensive care units. JAMA 2009; 302(21): 2323-9.
[http://dx.doi.org/10.1001/jama.2009.1754] [PMID: 19952319]
[http://dx.doi.org/10.1001/jama.2009.1754] [PMID: 19952319]
[3]
Otero RM, Nguyen HB, Huang DT, et al. Early goal-directed therapy in severe sepsis and septic shock revisited: concepts, controversies, and contemporary findings. Chest 2006; 130(5): 1579-95.
[http://dx.doi.org/10.1378/chest.130.5.1579] [PMID: 17099041]
[http://dx.doi.org/10.1378/chest.130.5.1579] [PMID: 17099041]
[4]
Lopez Nicole, Kobayashi eslie. Raul Coimbra A Comprehensive review of abdominal infections. World J Emerg Surg 2011; 6(1): 7.
[5]
Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 2016; 315(8): 801-10.
[http://dx.doi.org/10.1001/jama.2016.0287] [PMID: 26903338]
[http://dx.doi.org/10.1001/jama.2016.0287] [PMID: 26903338]
[6]
Qureshi SS, Lewis SM, Gant VA, Treacher D, Davis BH, Brown KA. Increased distribution and expression of CD64 on blood polymorphonuclear cells from patients with the systemic inflammatory response syndrome (SIRS). Clin Exp Immunol 2001; 125(2): 258-65.
[http://dx.doi.org/10.1046/j.1365-2249.2001.01596.x] [PMID: 11529918]
[http://dx.doi.org/10.1046/j.1365-2249.2001.01596.x] [PMID: 11529918]
[7]
Li S, Huang X, Chen Z, et al. Neutrophil CD64 expression as a biomarker in the early diagnosis of bacterial infection: a meta-analysis. Int J Infect Dis 2013; 17(1): e12-23.
[http://dx.doi.org/10.1016/j.ijid.2012.07.017] [PMID: 22940278]
[http://dx.doi.org/10.1016/j.ijid.2012.07.017] [PMID: 22940278]
[8]
Hoffmann JJ. Neutrophil CD64 as a sepsis biomarker. Biochem Med (Zagreb) 2011; 21(3): 282-90.
[http://dx.doi.org/10.11613/BM.2011.038] [PMID: 22420242]
[http://dx.doi.org/10.11613/BM.2011.038] [PMID: 22420242]
[9]
Davis BH, Olsen SH, Ahmad E, Bigelow NC. Neutrophil CD64 is an improved indicator of infection or sepsis in emergency department patients. Arch Pathol Lab Med 2006; 130(5): 654-61.
[PMID: 16683883]
[PMID: 16683883]
[10]
Gerrits JH, McLaughlin PMJ, Nienhuis BN, Smit JW, Loef B. Polymorphic mononuclear neutrophils CD64 index for diagnosis of sepsis in postoperative surgical patients and critically ill patients. Clin Chem Lab Med 2013; 51(4): 897-905.
[http://dx.doi.org/10.1515/cclm-2012-0279] [PMID: 23045384]
[http://dx.doi.org/10.1515/cclm-2012-0279] [PMID: 23045384]
[11]
Icardi M, Erickson Y, Kilborn S, Stewart B, Grief B, Scharnweber G. CD64 index provides simple and predictive testing for detection and monitoring of sepsis and bacterial infection in hospital patients. J Clin Microbiol 2009; 47(12): 3914-9.
[http://dx.doi.org/10.1128/JCM.00628-09] [PMID: 19846647]
[http://dx.doi.org/10.1128/JCM.00628-09] [PMID: 19846647]
[12]
Döcke WD, Randow F, Syrbe U, et al. Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nat Med 1997; 3(6): 678-81.
[http://dx.doi.org/10.1038/nm0697-678] [PMID: 9176497]
[http://dx.doi.org/10.1038/nm0697-678] [PMID: 9176497]
[13]
Monneret G, Venet F. Monocyte HLA-DR in sepsis: shall we stop following the flow? Crit Care 2014; 18(1): 102.
[http://dx.doi.org/10.1186/cc13179] [PMID: 24393356]
[http://dx.doi.org/10.1186/cc13179] [PMID: 24393356]
[14]
Venet F, Lukaszewicz AC, Payen D, Hotchkiss R, Monneret G. Monitoring the immune response in sepsis: a rational approach to administration of immunoadjuvant therapies. Curr Opin Immunol 2013; 25(4): 477-83.
[http://dx.doi.org/10.1016/j.coi.2013.05.006] [PMID: 23725873]
[http://dx.doi.org/10.1016/j.coi.2013.05.006] [PMID: 23725873]
[15]
Cheadle WG. 1993; The human leukocyte antigens and their relationship to infectionAm J Surg 165((2A Suppl)): 75S-81S.
[http://dx.doi.org/10.1016/S0002-9610(05)81210-3]
[http://dx.doi.org/10.1016/S0002-9610(05)81210-3]
[16]
Volk HD, Thieme M, Heym S, et al. Alterations in function and phenotype of monocytes from patients with septic disease--predictive value and new therapeutic strategies. Behring Inst Mitt 1991; (88): 208-15.
[PMID: 2049040]
[PMID: 2049040]
[17]
Hirsh M, Mahamid E, Bashenko Y, Hirsh I, Krausz MM. Overexpression of the high-affinity Fcgamma receptor (CD64) is associated with leukocyte dysfunction in sepsis. Shock 2001; 16(2): 102-8.
[http://dx.doi.org/10.1097/00024382-200116020-00003] [PMID: 11508860]
[http://dx.doi.org/10.1097/00024382-200116020-00003] [PMID: 11508860]
[18]
Velásquez S, Matute JD, Gámez LY, et al. Characterization of nCD64 expression in neutrophils and levels of s-TREM-1 and HMGB-1 in patients with suspected infection admitted in an emergency department. Biomedica 2013; 33(4): 643-52.
[PMID: 24652218]
[PMID: 24652218]
[19]
Papadimitriou-Olivgeris M, Lekka K, Zisimopoulos K, et al. Role of CD64 expression on neutrophils in the diagnosis of sepsis and the prediction of mortality in adult critically ill patients. Diagn Microbiol Infect Dis 2015; 82(3): 234-9.
[http://dx.doi.org/10.1016/j.diagmicrobio.2015.03.022] [PMID: 25921729]
[http://dx.doi.org/10.1016/j.diagmicrobio.2015.03.022] [PMID: 25921729]
[20]
de Jong E, de Lange DW, Beishuizen A, van de Ven PM, Girbes AR, Huisman A. Neutrophil CD64 expression as a longitudinal biomarker for severe disease and acute infection in critically ill patients. Int J Lab Hematol 2016; 38(5): 576-84.
[http://dx.doi.org/10.1111/ijlh.12545] [PMID: 27565453]
[http://dx.doi.org/10.1111/ijlh.12545] [PMID: 27565453]
[21]
Charles PE, Noel R, Massin F, et al. Significance of soluble triggering receptor expressed on myeloid cells-1 elevation in patients admitted to the intensive care unit with sepsis. BMC Infect Dis 2016; 16(1): 559.
[http://dx.doi.org/10.1186/s12879-016-1893-4] [PMID: 27729010]
[http://dx.doi.org/10.1186/s12879-016-1893-4] [PMID: 27729010]
[22]
Fischer G, Schneider EM, Moldawer LL, et al. CD64 surface expression on neutrophils is transiently upregulated in patients with septic shock. Intens Care Med 2001; 27(12): 1848-52.
[http://dx.doi.org/10.1007/s00134-001-1135-z]
[http://dx.doi.org/10.1007/s00134-001-1135-z]
[23]
Dimoula A, Pradier O, Kassengera Z, Dalcomune D, Turkan H, Vincent JL. Serial determinations of neutrophil CD64 expression for the diagnosis and monitoring of sepsis in critically ill patients. Clin Infect Dis 2014; 58(6): 820-9.
[http://dx.doi.org/10.1093/cid/cit936] [PMID: 24363321]
[http://dx.doi.org/10.1093/cid/cit936] [PMID: 24363321]
[24]
Chen Q, Shi J, Fei A, Wang F, Pan S, Wang W. Neutrophil CD64 expression is a predictor of mortality for patients in the intensive care unit. Int J Clin Exp Pathol 2014; 7(11): 7806-13.
[PMID: 25550820]
[PMID: 25550820]
[25]
Djordjevic D, Pejovic J, Surbatovic M, et al. prognostic value and
daily trend of interleukin-6, neutrophil cd64 expression, c-reactive
protein and lipopolysaccharide-binding protein in critically ill patients:
reliable predictors of outcome or not? J Med Biochem. 2015; 34(4): 431-9.
[http://dx.doi.org/10.1515/jomb-2015-0002] [PMID: 28356852]
[http://dx.doi.org/10.1515/jomb-2015-0002] [PMID: 28356852]
[26]
Danikas DD, Karakantza M, Theodorou GL, Sakellaropoulos GC, Gogos CA. Prognostic value of phagocytic activity of neutrophils and monocytes in sepsis. Correlation to CD64 and CD14 antigen expression. Clin Exp Immunol 2008; 154(1): 87-97.
[http://dx.doi.org/10.1111/j.1365-2249.2008.03737.x] [PMID: 18727624]
[http://dx.doi.org/10.1111/j.1365-2249.2008.03737.x] [PMID: 18727624]
[27]
Cid J, García-Pardo G, Aguinaco R, Sánchez R, Llorente A. Neutrophil CD64: diagnostic accuracy and prognostic value in patients presenting to the emergency department. Eur J Clin Microbiol Infect Dis 2011; 30(7): 845-52.
[http://dx.doi.org/10.1007/s10096-011-1164-7] [PMID: 21249409]
[http://dx.doi.org/10.1007/s10096-011-1164-7] [PMID: 21249409]
[28]
Gibot S, Bene MC, Noel R, et al. Combination biomarkers to diagnose sepsis in the critically ill patient Am J Respir Crit Care Med 1 2012; 186(1): 65-71.
[http://dx.doi.org/10.1164/rccm.201201-0037OC]
[http://dx.doi.org/10.1164/rccm.201201-0037OC]
[29]
Farias MG, de Lucena NP, Dal Bó S, de Castro SM. Neutrophil CD64 expression as an important diagnostic marker of infection and sepsis in hospital patients. J Immunol Methods 2014; 414: 65-8.
[http://dx.doi.org/10.1016/j.jim.2014.07.011] [PMID: 25180450]
[http://dx.doi.org/10.1016/j.jim.2014.07.011] [PMID: 25180450]
[30]
Righi S, Santambrogio L, Monsagrati A, et al. Clinical evaluation of neutrophil CD64 as a diagnostic marker of infection in a polyvalent intensive care unit. Infect Dis Clin Pract 2014; 22(1): 32-7.
[http://dx.doi.org/10.1097/IPC.0b013e31828f4b6a]
[http://dx.doi.org/10.1097/IPC.0b013e31828f4b6a]
[31]
Wang X, Li Z-Y, Zeng L, et al. Neutrophil CD64 expression as a diagnostic marker for sepsis in adult patients: a meta-analysis. Crit Care 2015; 19(1): 245.
[http://dx.doi.org/10.1186/s13054-015-0972-z] [PMID: 26059345]
[http://dx.doi.org/10.1186/s13054-015-0972-z] [PMID: 26059345]
[32]
Livaditi O, Kotanidou A, Psarra A, et al. Neutrophil CD64 expression and serum IL-8: sensitive early markers of severity and outcome in sepsis. Cytokine 2006; 36(5-6): 283-90.
[http://dx.doi.org/10.1016/j.cyto.2007.02.007] [PMID: 17368039]
[http://dx.doi.org/10.1016/j.cyto.2007.02.007] [PMID: 17368039]
[33]
Hsu KH, Chan MC, Wang JM, Lin LY, Wu CL. Comparison of Fcγ receptor expression on neutrophils with procalcitonin for the diagnosis of sepsis in critically ill patients. Respirology 2011; 16(1): 152-60.
[http://dx.doi.org/10.1111/j.1440-1843.2010.01876.x] [PMID: 20946336]
[http://dx.doi.org/10.1111/j.1440-1843.2010.01876.x] [PMID: 20946336]
[34]
Lekkou A, Karakantza M, Mouzaki A, Kalfarentzos F, Gogos CA. Cytokine production and monocyte HLA-DR expression as predictors of outcome for patients with community-acquired severe infections. Clin Diagn Lab Immunol 2004; 11(1): 161-7.
[http://dx.doi.org/10.1128/CDLI.11.1.161-167.2004] [PMID: 14715564]
[http://dx.doi.org/10.1128/CDLI.11.1.161-167.2004] [PMID: 14715564]
[35]
Monneret G, Lepape A, Voirin N, et al. Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock. Intensive Care Med 2006; 32(8): 1175-83.
[http://dx.doi.org/10.1007/s00134-006-0204-8] [PMID: 16741700]
[http://dx.doi.org/10.1007/s00134-006-0204-8] [PMID: 16741700]
[36]
Fu Q, Cui NQ, Yu WL. The relationship between immune imbalance and intestinal barrier dysfunction in patients with severe intra-abdominal infections Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2009; 21(7): 429-33.
[PMID: 19615138]
[PMID: 19615138]
[37]
Tian Y, Tao T, Zhu J, et al. Soluble tumor necrosis factor related apoptosis inducing ligand level as a predictor of severity of sepsis and the risk of mortality in septic patients. PLoS One 2013; 8(12)e82204
[http://dx.doi.org/10.1371/journal.pone.0082204] [PMID: 24349222]
[http://dx.doi.org/10.1371/journal.pone.0082204] [PMID: 24349222]
[38]
Drewry AM, Ablordeppey EA, Murray ET, et al. Comparison of monocyte human leukocyte antigen-DR expression and stimulated tumor necrosis factor alpha production as outcome predictors in severe sepsis: a prospective observational study. Crit Care 2016; 20(1): 334.
[http://dx.doi.org/10.1186/s13054-016-1505-0] [PMID: 27760554]
[http://dx.doi.org/10.1186/s13054-016-1505-0] [PMID: 27760554]
[39]
Perry SE, Mostafa SM, Wenstone R, Shenkin A, McLaughlin PJ. Is low monocyte HLA-DR expression helpful to predict outcome in severe sepsis? Intensive Care Med 2003; 29(8): 1245-52.
[http://dx.doi.org/10.1007/s00134-003-1686-2] [PMID: 12774155]
[http://dx.doi.org/10.1007/s00134-003-1686-2] [PMID: 12774155]
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