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Current Medical Imaging

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ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

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Research Article

Organic Lesions in the Brain MRI of Children with Febrile Seizure

Author(s): Alireza Nezami, Fariba Tarhani* and Negin Koochak Shoshtari

Volume 17, Issue 1, 2021

Published on: 26 February, 2020

Page: [148 - 154] Pages: 7

DOI: 10.2174/1573405616666200226103615

Price: $65

Abstract

Objective: Seizure is the most common neurological disorders in children, where 4-10% of the cases experience at least one seizure before the age of 16. The most frequent causes of seizures in children are fever, epilepsy, infection and brain damage. The aim of this study was to investigate the frequency of organic lesions in MRI of children with seizures unrelated to fever.

Materials and Methods: This cross-sectional study included children presented with fever-unrelated seizures. The MRI was examined by a radiologist to identify abnormal findings in each patient. A researcher-made questionnaire including general information, history of head trauma, obstructed labor and the history of seizure was completed for the patients.

Results: Of 287 children with fever-related seizure, 127 (45.7%) were male and 151 (54.3%) were female. History of seizure, history of obstructed labor, abnormal MRI, complete delay, use of antiepileptic drug and history of trauma were 22(9.9%), 1 (0.4%), 11(4%), 5(1.8%), 259(93.2%) and 12 (4.3%), respectively. Of 11 patients with abnormal MRI, 4 had MTS lesions, 2 had tumor lesions, 2 had scarring trauma, 1 had an epidural abscess and 1 had meningitis. The frequency of organic lesions had no significant differences based on gender, use of antiepileptic drug and traumatic history, but it had a significant relation with obstructed labor andthehistory of seizure.

Conclusion: The results showed that organic brain lesions in children with fever-unrelated seizure had a significant relationship with the history of seizure and obstructed maternal labor.

Keywords: MRI, organic lesions, fever-unrelated seizure, children, neurological disorder, epilepsy, EEG.

Graphical Abstract

[1]
Hsieh DT, Chang T, Tsuchida TN, et al. New-onset afebrile seizures in infants: role of neuroimaging. Neurology 2010; 74(2): 150-6.
[http://dx.doi.org/10.1212/WNL.0b013e3181c91847] [PMID: 20065250]
[2]
Sadeghi E, Inalou S, Rafie S. Risk of seizure recurrence following a first unprovoked seizure in childhood. J Urmia Univ Med Sci 2008; 19(3): 215-23.
[3]
Talebian A, Toliyat SMS. Positive familial convulsive attaches and fever among children. KAUMSJ 1999; 2(4): 70-4.
[4]
Oguz A, Kurul S, Dirik E. Relationship of epilepsy-related factors to anxiety and depression scores in epileptic children. J Child Neurol 2002; 17(1): 37-40.
[http://dx.doi.org/10.1177/088307380201700109] [PMID: 11913568]
[5]
Zerr DM, Blume HK, Berg AT, et al. Nonfebrile illness seizures: a unique seizure category? Epilepsia 2005; 46(6): 952-5. [Online First: Epub Date].
[http://dx.doi.org/10.1111/j.1528-1167.2005.65204.x] [PMID: 15946338]
[6]
Pavlidou E, Hagel C, Panteliadis C. Febrile seizures: recent developments and unanswered questions. Child's Nervous System 2013; 29(11): 2011-7.
[http://dx.doi.org/10.1007/s00381-013-2224-3]
[7]
Ponnatapura J, Vemanna S, Ballal S, Singla A. Utility of magnetic resonance imaging brain epilepsy protocol in new-onset seizures: How is it different in developing countries? J Clin Imaging Sci 2018; 8: 43-3.
[http://dx.doi.org/10.4103/jcis.JCIS_38_18] [PMID: 30546927]
[8]
Griffiths PD, Coley SC, Connolly DJ, et al. MR imaging of patients with localisation-related seizures: initial experience at 3.0T and relevance to the NICE guidelines. Clin Radiol 2005; 60(10): 1090-9.
[http://dx.doi.org/10.1016/j.crad.2005.05.017] [PMID: 16179169]
[9]
Urbach H, Hattingen J, von Oertzen J, et al. MR imaging in the presurgical workup of patients with drug-resistant epilepsy. AJNR Am J Neuroradiol 2004; 25(6): 919-26.
[PMID: 15205124]
[10]
Çakırer S, Başak M, Mutlu A, Galip GM. MR imaging in epilepsy that is refractory to medical therapy. Eur Radiol 2002; 12(3): 549-58.
[http://dx.doi.org/10.1007/s003300101036] [PMID: 11870469]
[11]
King MA, Newton MR, Jackson GD, et al. Epileptology of the first-seizure presentation: a clinical, electroencephalographic, and magnetic resonance imaging study of 300 consecutive patients. Lancet 1998; 352(9133): 1007-11.
[http://dx.doi.org/10.1016/S0140-6736(98)03543-0] [PMID: 9759742]
[12]
Bernal B, Altman NR. Evidence-based medicine: neuroimaging of seizures. Neuroimaging Clin N Am 2003; 13(2): 211-24. [Online First: Epub Date].
[http://dx.doi.org/10.1016/S1052-5149(03)00019-4] [PMID: 13677802]
[13]
Deblaere K, Achten E. Structural magnetic resonance imaging in epilepsy. Eur Radiol 2008; 18(1): 119-29. [Online First: Epub Date].
[http://dx.doi.org/10.1007/s00330-007-0710-2] [PMID: 17899110]
[14]
Schaller B, Rüegg SJ. Brain tumor and seizures: pathophysiology and its implications for treatment revisited. Epilepsia 2003; 44(9): 1223-32. [Online First: Epub Date].
[http://dx.doi.org/10.1046/j.1528-1157.2003.05203.x] [PMID: 12919395]
[15]
Kalnin AJ, Fastenau PS, deGrauw TJ, et al. Magnetic resonance imaging findings in children with a first recognized seizure. Pediatr Neurol 2008; 39(6): 404-14. [Online First: Epub Date].
[http://dx.doi.org/10.1016/j.pediatrneurol.2008.08.008] [PMID: 19027586]
[16]
Berg AT, Testa FM, Levy SR, Shinnar S. Neuroimaging in children with newly diagnosed epilepsy: A community-based study. Pediatrics 2000; 106(3): 527-32. [Online First: Epub Date].
[http://dx.doi.org/10.1542/peds.106.3.527] [PMID: 10969098]
[17]
Hermann B, Seidenberg M, Bell B, et al. The neurodevelopmental impact of childhood-onset temporal lobe epilepsy on brain structure and function. Epilepsia 2002; 43(9): 1062-71.
[http://dx.doi.org/10.1046/j.1528-1157.2002.49901.x] [PMID: 12199732]
[18]
Cendes F, Andermann F, Gloor P, et al. Atrophy of mesial structures in patients with temporal lobe epilepsy: cause or consequence of repeated seizures? Ann Neurol 1993; 34(6): 795-801. [Online First: Epub Date].
[http://dx.doi.org/10.1002/ana.410340607] [PMID: 8250528]
[19]
Widjaja E, Zarei Mahmoodabadi S, Go C, et al. Reduced cortical thickness in children with new-onset seizures. AJNR Am J Neuroradiol 2012; 33(4): 673-7. Online First: Epub Date.
[http://dx.doi.org/10.3174/ajnr.A2982] [PMID: 22282450]
[20]
Gergont A, Kroczka S, Steczkowska M, Zajac A. Structural MRI changes in children with epilepsy aged 2-18 years. Przegl Lek 2010; 67(11): 1113-9.
[PMID: 21442960]
[21]
Von Oertzen J, Urbach H, Jungbluth S, et al. Standard magnetic resonance imaging is inadequate for patients with refractory focal epilepsy. J Neurol Neurosurg Psychiatry 2002; 73(6): 643-7.
[http://dx.doi.org/10.1136/jnnp.73.6.643] [PMID: 12438463]
[22]
Urbach H. Imaging of the epilepsies. Eur Radiol 2005; 15(3): 494-500. [Online First: Epub Date].
[http://dx.doi.org/10.1007/s00330-004-2629-1] [PMID: 15678321]
[23]
Garcia-Ramos C, Jackson DC, Lin JJ, et al. Cognition and brain development in children with benign epilepsy with centrotemporal spikes. Epilepsia 2015; 56(10): 1615-22. [Online First: Epub Date].
[http://dx.doi.org/10.1111/epi.13125] [PMID: 26337046]

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