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Current Nutrition & Food Science

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Mini-Review Article

Nutritional and Medicinal Values of Chlorophytum borivilianum: Minireview of Current Status and Future Possibilities

Author(s): Ravindra Verma*, Vaibhav Misra and Prakash S. Bisen

Volume 16, Issue 9, 2020

Page: [1338 - 1345] Pages: 8

DOI: 10.2174/1573401316666200225122210

Price: $65

Abstract

Background: The knowledge of herbs and its uses is not fully explored in India. Chlorophytum borivilianum (family: Liliaceae) is one of the highest valued medicinal plants found in the Indian forest. Traditionally, it is used after delivery by the females in different compositions in the form of “Laddoos”.

Objective: This study reviewed the nutritional and medicinal applications of Chlorophytum borivilianum properties with the current status and future possibilities. Chlorophytum borivilianum is a well-known tonic and an aphrodisiac drug extensively used in Ayurvedic medicines. The main source is from the forest area, efforts are made for its cultivation to fulfill the growing demand.

Methods: A detailed study was carried out by analyzing national and international scientific databases like Pub Med, SciFinder, Scopus and Web of Science, thesis, and recognized books. The researcher himself cultivated Chlorophytum borivilianum on his farm during the period from 2000 to 2008.

Results: Chlorophytum borivilianum roots are used for the preparation of nutritional tonic used in general sexual weaknesses. It has a huge and consistent demand in the national and international markets. The pharmaceutical and therapeutic value of Chlorophytum borivilianum has a great significance due to the presence of a specific constituent, i.e., saponins of secondary metabolites. Recent studies of Chlorophytum borivilianum have identified a wide range of pharmacological applications, most importantly, aphrodisiac, immune-modulatory, and anticancer activities.

Conclusion: Some of the barriers are observed, such as a lack of research and development on highyielding varieties, quality control, and products and process development. The difficulties in marketing, an unestablished local market for primary processed products, unskilled human power, and equipment, knowledge of the latest technologies and market information are the major constraints observed in the promotion of Chlorophytum borivilianum.

Keywords: Chlorophytum borivilianum, ethnobotanical, harvesting, herbal, medicinal properties, nutritional properties.

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[1]
Wakdikar S. Global health care challenge: Indian experiences and new prescriptions. Electron J Biotechnol 2004; 7(3): 2-3.
[2]
Sen S, Chakraborty R. Revival, modernization and integration of Indian traditional herbal medicine in clinical practice: Importance, challenges and future. J Tradit Complement Med 2016; 7(2): 234-44.
[http://dx.doi.org/10.1016/j.jtcme.2016.05.006] [PMID: 28417092]
[3]
Kumar B, Vijayakumar M, Govindarajan R, Pushpangadan P. Ethnopharmacological approaches to wound healing--exploring medicinal plants of India. J Ethnopharmacol 2007; 114(2): 103-13.
[http://dx.doi.org/10.1016/j.jep.2007.08.010] [PMID: 17884316]
[4]
Katoch M, Kumar R, Pal S, Ahuja A. Identification of Chlorophytum species (C. borivilianum, C. arundinaceum, C. laxum, C. capense and C. comosum) using molecular markers. Ind Crops Prod 2010; 32(3): 389-93.
[http://dx.doi.org/10.1016/j.indcrop.2010.06.001]
[5]
Patil SM, Chandanshive VV, Tamboli AS, Adsul AA, Yadav SR, Govindwar SP. Analysis of genetic variability in endemic medicinal plants of genus Chlorophytum from the Indian subcontinent using amplified fragment length polymorphism marker. C R Biol 2015; 338(12): 838-45.
[http://dx.doi.org/10.1016/j.crvi.2015.09.006] [PMID: 26573876]
[6]
Kalra S, Puniya BL, Kulshreshtha D, et al. De Novo transcriptome sequencing reveals important molecular networks and metabolic pathways of the plant, Chlorophytum borivilianum. PLoS One 2013; 8(12)e83336
[http://dx.doi.org/10.1371/journal.pone.0083336]] [PMID: 24376689]
[7]
Kalra S, Kumar S, Singh K. Molecular analysis of squalene epoxidase gene from Chlorophytum borivilianum (Sant. and Fernand.). J Plant Biochem Biotechnol 2015; 24(4): 417-24.
[http://dx.doi.org/10.1007/s13562-014-0292-4]
[8]
Maiti S, Geetha KA. Characterization, genetic improvement and cultivation of Chlorophytum borivilianum—an important medicinal plant of India. Plant Genet Resour 2005; 3(2): 264-72.
[http://dx.doi.org/10.1079/PGR200579]
[9]
Samantarray S, Ngangkhan U. Evaluation of genetic diversity in Chlorophytum borivilianum (Santp. and Fernan.) using molecular markers: An endangered medicinal plant. In: El-Shemy HA, Ed.Active ingredients from aromatic and medicinal plants. UK: IntechOpen 2017; pp. 50-70.
[10]
Khanam Z, Singh O, Singh R, Bhat IUH. Safed Musli (Chlorophytum borivilianum): a review of its botany, ethnopharmacology and phytochemistry. J Ethnopharmacol 2013; 150(2): 421-41.
[http://dx.doi.org/10.1016/j.jep.2013.08.064] [PMID: 24045177]
[11]
https://www.nmpb.nic.in/content/medicinal-plants-cultivation
[12]
Kumar A, Jnanesha AC, Venugopal S, Nagaraju S. Post-harvest and value additions of important medicinal crops. In: Hussain M, EdResearch Trends in Medicinal Plant Sciences. New Delhi: AkiNik Publications 2019; pp. 51-75.
[13]
Goyal RK, Singh PK, Goyal SK. Satavar and safed musli-ingredients for herbal food: an appraisal. J Nutr Health Food Eng 2018; 8(3): 253-8.
[http://dx.doi.org/10.15406/jnhfe.2018.08.00279]
[14]
Singh A, Chauhan HS. Safed musli (Chlorophytum borivilianum): Distribution, biodiversity and cultivation. Curr Res Med Aromat Plants 2003; 25: 712-9.
[15]
Govindarajan R, Sreevidya N, Vijayakumar M, et al. In vitro antioxidant activity of ethanolic extract of Chlorophytum borivilianum. Nat Prod Sci 2005; 11(3): 165-9.
[16]
Chauhan NS, Sharma V, Dixit VK, Thakur M. A review on plants used for improvement of sexual performance and virility. BioMed Res Int 2014; 2014868062
[http://dx.doi.org/10.1155/2014/868062] [PMID: 25215296]
[17]
Dutta S, Sengupta P. Medicinal herbs in the management of male infertility. J Preg Reprod 2018; 2: 10-5.
[http://dx.doi.org/10.15761/JPR.1000128]
[18]
Thakur GS, Bag M, Sanodiya BS, et al. Chlorophytum borivilianum: a white gold for biopharmaceuticals and neutraceuticals. Curr Pharm Biotechnol 2009; 10(7): 650-66.
[http://dx.doi.org/10.2174/138920109789542084] [PMID: 19751181]
[19]
Singh D, Pokhriyal B, Joshi YM, Kadam V. Phytopharmacological aspects of Chlorophytum borivilianum (safed musli): a review. Int J Res Pharm Chem 2012; 2(3): 853-9.
[20]
Sharma P, Kaushal K. Chandrul, Chlorophytum borivilianum (safed musli): a vital herbal drug. Int J Pharm Med Res 2017; 5(1): 401-11.
[21]
Sharma A, Shanker C, Tyagi LK, Singh M, Rao CV. Herbal medicine for market potential in India: an overview. Acad J Plant Sci 2008; 1(2): 26-36.
[22]
Gunjan M, Naing TW, Saini RS, Ahmad A, Naidu JR, Kumar I. Marketing trends & future prospects of herbal medicine in the treatment of various disease. World J Pharm Res 2015; 4(9): 132-55.
[23]
Debnath M, Malik CP, Bisen PS. Micropropagation: a tool for the production of high quality plant-based medicines. Curr Pharm Biotechnol 2006; 7(1): 33-49.
[http://dx.doi.org/10.2174/138920106775789638] [PMID: 16472132]
[24]
Tripathi RK, Dethe PD, Bhojne SK, Raut AA, Rege NN. A prospective, randomized, placebo-controlled, double-blind comparative pilot study to evaluate the efficacy of Chlorophytum borivilianum on physical performance. Indian J Pharmacol 2019; 51(3): 150-6.
[http://dx.doi.org/10.4103/ijp.IJP_115_18] [PMID: 31391682]
[25]
Chen L, Shi GR, Huang DD, et al. Male sexual dysfunction: a review of literature on its pathological mechanisms, potential risk factors, and herbal drug intervention. Biomed Pharmacother 2019; 112108585
[http://dx.doi.org/10.1016/j.biopha.2019.01.046] [PMID: 30798136]
[26]
Phurailatpam K, Geetha KA, Gajbhiye NA, Saravanan R, Maiti S. Comparative study of Chlorophytum borivilianum Sant. & Fernand. and C. arundinaceum Baker-Two’Safed Musli species used as vital tonics in Indian system of medicine. Phytomorphology 2009; 59(1): 77.
[27]
Rungsung W, Dutta S, Das D, Hazra J. A brief review on the botanical aspects and therapeutic potentials of important Indian medicinal plants. Int J Herbal Med 2013; 1(3): 38-45.
[28]
Singh KM, Kumar A, Singh R, Kumar U. Medicinal and aromatic plants for enhancing farm income: the case of Bihar 2013. Available from: https://mpra.ub.uni-muenchen.de/50571/
[http://dx.doi.org/10.2139/ssrn.2341506]
[29]
Purohit SD, Teixeira da Silva JA, Habibi N. Current approaches for cheaper and better micropropagation technologies. Int J Plant Dev Biol 2011; 5: 1-36.
[30]
Kumar A, Aggarwal D, Gupta P, Reddy MS. Factors affecting in vitro propagation and field establishment of Chlorophytum borivilianum. Biol Plant 2010; 54(4): 601-6.
[http://dx.doi.org/10.1007/s10535-010-0109-9]
[31]
Rizvi MZ, Kukreja AK, Khanuja SPS. In vitro culture of Chlorophytum borivilianum Sant. et Fernand. in liquid culture medium as a cost-effective measure. Curr Sci 2007; 92(1): 87-90.
[32]
Ashraf MF, Aziz MA, Kemat N, Ismail I. Effect of cytokinin types, concentrations and their interactions on in vitro shoot regeneration of Chlorophytum borivilianum Sant. & Fernandez. Electron J Biotechnol 2014; 17(6): 275-9.
[http://dx.doi.org/10.1016/j.ejbt.2014.08.004]
[33]
Dave A, Bilochi G, Purohit SD. Scaling-up production and field performance of micropropagated medicinal herb ‘Safed Musli’ (Chlorophytum borivilianum). In Vitro Cell Dev Biol Plant 2003; 39(4): 419-24.
[http://dx.doi.org/10.1079/IVP2003431]
[34]
Dave S, Tarafdar JC. Stimulatory synthesis of saponin by mycorrhizal fungi in Safed Musli (Chlorophytum borivilianum) tubers. Int Res J Agric Sci Soil Sci 2011; 1: 137-41.
[35]
Kumar D, Arya V, Kaur R, Bhat ZA, Gupta VK, Kumar V. A review of immunomodulators in the Indian traditional health care system. J Microbiol Immunol Infect 2012; 45(3): 165-84.
[http://dx.doi.org/10.1016/j.jmii.2011.09.030] [PMID: 22154993]
[36]
Goyal S, Arora J, Ramawat KG. Biotechnological approaches to medicinal plants of aravalli hills: conservation and scientific validation of biological activities Biotechnology and Biodiversity. Cham: Springer 2014; pp. 203-45.
[http://dx.doi.org/10.1007/978-3-319-09381-9_11]
[37]
Giribabu N, Kumar KE, Rekha SS, Muniandy S, Salleh N. Chlorophytum borivilianum (safed musli) root extract prevents impairment in characteristics and elevation of oxidative stress in sperm of streptozotocin-induced adult male diabetic Wistar rats. BMC Complement Altern Med 2014; 14(1): 291.
[http://dx.doi.org/10.1186/1472-6882-14-291] [PMID: 25104050]
[38]
Ashraf MF, Aziz MA, Stanslas J, Kadir MA. Optimization of immersion frequency and medium substitution on microtuberization of Chlorophytum borivilianum in RITA system on production of saponins. Process Biochem 2013; 48(1): 73-7.
[http://dx.doi.org/10.1016/j.procbio.2012.12.001]
[39]
Kumar S, Kalra S, Kumar S, Kaur J, Singh K. Differentially expressed transcripts from leaf and root tissue of Chlorophytum borivilianum: a plant with high medicinal value. Gene 2012; 511(1): 79-87.
[http://dx.doi.org/10.1016/j.gene.2012.09.046] [PMID: 23000016]
[40]
Kaushik N. Saponins of Chlorophytum species. Phytochem Rev 2005; 4(2-3): 191-6.
[http://dx.doi.org/10.1007/s11101-005-2607-5]
[41]
Haque R, Saha S, Bera T. A peer reviewed of general literature on Chlorophytum borivilianum commercial medicinal plant. Int J Drug Develop Res 2011; 3: 140-55.
[42]
Kumar S, Kalra S, Singh B, Kumar A, Kaur J, Singh K. RNA-Seq mediated root transcriptome analysis of Chlorophytum borivilianum for identification of genes involved in saponin biosynthesis. Funct Integr Genomics 2016; 16(1): 37-55.
[http://dx.doi.org/10.1007/s10142-015-0465-9] [PMID: 26458557]
[43]
Pathak S, Agarwal AV, Agarwal P, Trivedi PK. Secondary metabolite pathways in medicinal plants: Approaches in reconstruction and analysis Molecular approaches in plant biology and environmental challenges. Singapore: Springer 2019; pp. 339-64.
[http://dx.doi.org/10.1007/978-981-15-0690-1_16]
[44]
Desai S, Desai P, Mankad M, Patil G, Patel MA, Narayanan S. Assessment of genetic variability among various genotypes of critically endangered and medicinally important species: Chlorophytum borivilianum using RAPD markers. Eur J Technol and Bioscie 2018; 6(6): 8-12.
[45]
Kaur G. Studies of shoot organogenesis in Chlorophytm borivilianum Sant. et Fernand. Doctoral Dissertation, Thapar Institute, India 2018.
[46]
Dwivedi R, Sharma DK. Assessment of genetic diversity among collected genotypes of Chlorophytum borivilianum using random amplified polymorphic DNA (RAPD) markers. Afr J Biotechnol 2011; 10(27): 5268-72.
[47]
Mehta AA, Behera LK, Jha SK, Dholariya CA, Jadeja DB. Genetic divergence study for growth characters among the accessions of safed musli. IJCS 2019; 7(1): 2349-51.
[48]
Pandey A, Tomer AK, Bhandari DC, Pareek SK. Towards collection of wild relatives of crop plants in India. Genet Resour Crop Evol 2008; 55(2): 187-202.
[http://dx.doi.org/10.1007/s10722-007-9227-4]
[49]
Bhattacharyya R, Bhattacharya S, Chaudhuri S. Conservation and documentation of the medicinal plant resources of India Human exploitation and biodiversity conservation. Dordrecht: Springer 2006; pp. 365-77.
[http://dx.doi.org/10.1007/978-1-4020-5283-5_20]
[50]
Barik SK, Tiwari ON, Adhikari D, Singh PP, Tiwary R, Barua S. Geographic distribution pattern of threatened plants of India and steps taken for their conservation. Curr Sci 2018; 114(3): 470.
[http://dx.doi.org/10.18520/cs/v114/i03/470-503]
[51]
Krishnan S, Moreau T, Kuehny J, Novy A, Greene SL, Khoury CK. Resetting the table for people and plants: botanic gardens and research organizations collaborate to address food and agricultural plant blindness. Plants People Planet 2019; 1(3): 157-63.
[52]
Knapp S. People and plants: the unbreakable bond. Plants People Planet 2019; 1(1): 20-6.
[53]
Tandon P, Kumaria S, Das MC. Plant resources of India: potentials for future development. Proc Natl Acad Sci, India, Sect B Biol Sci 2012; 82(2): 283-9.
[http://dx.doi.org/10.1007/s40011-012-0104-3]
[54]
Patel DK, Kumar R, Prasad SK, Hemalatha S. Pharmacologically screened aphrodisiac plant-A review of current scientific literature. Asian Pac J Trop Biomed 2011; 1(1): S131-8.
[http://dx.doi.org/10.1016/S2221-1691(11)60140-8]
[55]
Pratap SA, Rajender S. Potent natural aphrodisiacs for the management of erectile dysfunction and male sexual debilities. Front Biosci (Schol Ed) 2012; 4: 167-80.
[http://dx.doi.org/10.2741/s259] [PMID: 22202051]
[56]
Hussain SA, Hameed A, Nasir F, Wu Y, Suleria HAR, Song Y. Evaluation of the spermatogenic activity of polyherbal formulation in oligospermic males. BioMed Res Int 2018; 20182070895
[http://dx.doi.org/10.1155/2018/2070895] [PMID: 30148161]
[57]
Malviya N, Malviya S, Jain S, Vyas S. A review of the potential of medicinal plants in the management and treatment of male sexual dysfunction. Andrologia 2016; 48(8): 880-93.
[http://dx.doi.org/10.1111/and.12677] [PMID: 27681645]
[58]
Acharya D, Mitaine-Offer AC, Kaushik N, et al. Cytotoxic spirostane-type saponins from the roots of Chlorophytum borivilianum. J Nat Prod 2009; 72(1): 177-81.
[http://dx.doi.org/10.1021/np800559z] [PMID: 19128156]
[59]
Acharya D, Mitaine‐Offer AC, Kaushik N, Miyamoto T, Paululat T, Lacaille‐Dubois MA. Furostane-type steroidal saponins from the roots of Chlorophytum borivilianum. Helv Chim Acta 2008; 91(12): 2262-9.
[http://dx.doi.org/10.1002/hlca.200890246]
[60]
Kenjale R, Shah R, Sathaye S. Effects of Chlorophytum borivilianum on sexual behaviour and sperm count in male rats. Phytother Res 2008; 22(6): 796-801.
[http://dx.doi.org/10.1002/ptr.2369] [PMID: 18412148]
[61]
Rath SK, Panja AK. Clinical evaluation of root tubers of shweta musali (Chlorophytum borivilianum L.) and its effect on semen and testosterone. Ayu 2013; 34(3): 273-5.
[http://dx.doi.org/10.4103/0974-8520.123118] [PMID: 24501522]
[62]
Visavadiya NP, Soni B, Dalwadi N, Madamwar D. Chlorophytum borivilianum as potential terminator of free radicals in various in vitro oxidation systems. Drug Chem Toxicol 2010; 33(2): 173-82.
[http://dx.doi.org/10.3109/01480540903311068] [PMID: 20307144]
[63]
Kumar M, Meena P, Verma S, Kumar M, Kumar A. Anti-tumour, anti-mutagenic and chemomodulatory potential of Chlorophytum borivilianum. Asian Pac J Cancer Prev 2010; 11(2): 327-34.
[PMID: 20843110]
[64]
Deore SL, Khadabadi SS. Standardisation and pharmaceutical evaluation of Chlorophytum borivilianum mucilage. Rasayan J Chem 2008; 1(4): 887-92.
[65]
Mahajan GK, Mahajan AY, Mahajan RT. Efficacy of aphrodisiac plants towards improvement in semen quality and motility in infertile males. J Complement Integr Med 2012; 9(1): 6.
[http://dx.doi.org/10.1515/1553-3840.1520] [PMID: 22499723]
[66]
Visavadiya NP, Narasimhacharya AV. Ameliorative effect of Chlorophytum borivilianum root on lipid metabolism in hyperlipaemic rats. Clin Exp Pharmacol Physiol 2007; 34(3): 244-9.
[http://dx.doi.org/10.1111/j.1440-1681.2007.04579.x PMID: 17250646]
[67]
Kaur R, Arora S, Thukral A. Quantitative and qualitative analysis of saponins in different plant parts of Chlorophytum borivilianum. Int J Pharma Bio Sci 2015; 6(1): 826-35.
[68]
Thakur M, Bhargava S, Praznik W, Loeppert R, Dixit VK. Effect of Chlorophytum Borivilianum Santapau and Fernandes on sexual dysfunction in hyperglycemic male rats. Chin J Integr Med 2009; 15(6): 448-53.
[http://dx.doi.org/10.1007/s11655-009-0448-6] [PMID: 20082251]
[69]
Sharma VK, Mazumdar B. Versatility of safed musali (Indian viagra) in human ailments. Proteins 2012; 8: 8-5.
[70]
Nikam VK. Physiological studies in a medicinal plant Chlorophytum borivilianum Sant and Fernad PhD Thesis 2017.

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