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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Design, Synthesis and Anticancer Evaluation of Acetamides Comprising 1,2,3-triazole, 1,3,4-thiadiazole and Isothiazolo[4,3-b]pyridine Rings

Author(s): Shaik Shahinshavali, Nuthalapati Poojith, Venkat Rao Guttikonda, Reddymasu Sreenivasulu and Mandava Venkata Basaveswara Rao*

Volume 17, Issue 11, 2020

Page: [864 - 871] Pages: 8

DOI: 10.2174/1570178617666200225102939

Price: $65

Abstract

We have synthesized a library of new 1,2,3-triazole incorporated 1,3,4-thiadiazoleisothiazolo[ 4,3-b]pyridine derivatives 12a-j and have screened these products for their anticancer activities against four human cancer cell lines such as MCF-7 (breast cancer), A549 (lung cancer), DU-145 (prostate cancer), and MDA MB-231 (breast cancer) using MTT assay with etoposide as a positive control. Among them, compound 12e has shown excellent activities against MCF-7, A549, DU-145, and MDA-MB-231 with IC50 values of 0.53±0.055 μM, 0.18±0.077 μM, 0.10±0.082 μM, and 0.92±0.041 μM, respectively.

Keywords: 1, 2, 3-triazole, 1, 3, 4-thiadiazole, anticancer activity, azetepa, Carboxyamido triazole (CAI), isothiazolo[4, 3- b]pyridine.

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