Limitations on the pharmacotherapy and a high prevalence worldwide are critical issues related to depression and cancer. It is highly discussed in the field that a dysregulation of intracellular Ca2+ homeostasis is involved in the pathogenesis of both diseases. In addition, depression rises the risk of cancer incidence. Consistent data support the concept that depression is an independent risk issue for cancer. However, the cellular mechanisms involved in this link between depression and cancer remain uncertain. Considering our previous reports about Ca2+ and cAMP signalling pathways (Ca2+/cAMP signalling), I herein discussed the putative contribution of Ca2+/cAMP signalling in this link between depression and cancer. Then, it is important to consider depression into account during the process of prevention, and treatment, of cancer.
Keywords: Depression, Cancer, Ca2+/cAMP signaling, Homeostasis, Pharmacotherapy, Homeostasis
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