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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

A Simple Synthesis of the Anticancer Drug Altretamine

Author(s): Vu Binh Duong, Pham Van Hien, Tran Thai Ngoc, Phan Dinh Chau and Tran Khac Vu*

Volume 17, Issue 8, 2020

Page: [628 - 630] Pages: 3

DOI: 10.2174/1570178617666200210111041

Price: $65

Abstract

A simple and practical method for the synthesis on a large scale of altretamine (1), a wellknown antitumor drug, has been successfully developed. The synthesis method involves the conversion of cyanuric chloride (2) into altretamine (1) by dimethylamination of 2 with an aqueous solution of 40% dimethylamine and potassium hydroxide in 1, -dioxan 4in one step to give altretamine (1) in high yield.

Keywords: Altretamine, hexamethylmelamine, cyanuric chloride, dimethylamine, antitumor, potassium hydroxide, sodium hydroxide.

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