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Review Article

Glycation With Fructose: The Bitter Side of Nature’s Own Sweetener

Author(s): Samreen Amani and Shamila Fatima*

Volume 16, Issue 9, 2020

Page: [962 - 970] Pages: 9

DOI: 10.2174/1389450121666200204115751

Price: $65

Abstract

Fructose is a ketohexose and sweetest among all the natural sugars. Like other reducing sugars, it reacts readily with the amino- and nucleophilic groups of proteins, nucleic acids and other biomolecules resulting in glycation reactions. The non-enzymatic glycation reactions comprise Schiff base formation, their Amadori rearrangement followed by complex and partly incompletely understood reactions culminating in the formation of Advance Glycation End products (AGEs). The AGEs are implicated in complications associated with diabetes, cardiovascular disorders, Parkinson’s disease, etc.

Fructose is highly reactive and forms glycation products that differ both in structure and reactivity as compared to those formed from glucose. Nearly all tissues of higher organisms utilize fructose but only a few like the ocular lens, peripheral nerves erythrocytes and testis have polyol pathway active for the synthesis of fructose. Fructose levels rarely exceed those of glucose but, in tissues that operate the polyol pathway, its concentration may rise remarkably during diabetes and related disorders. Diet contributes significantly to the body fructose levels however, availability of technologies for the large scale and inexpensive production of fructose, popularity of high fructose syrups as well as the promotion of vegetarianism have resulted in a remarkable increase in the consumption of fructose. In vivo glycation reactions by fructose, therefore, assume remarkable significance. The review, therefore, aims to highlight the uniqueness of glycation reactions with fructose and its role in some pathophysiological situations.

Keywords: AGE, aging, diabetes, fructation, glycation, protein cross linking.

[1]
Maillard LC. Action des acides amines sur lesucres: formation des melanoidines per voie methodique. C R Hebd Seances Acad Sci 1912; 154: 66-8.
[2]
Koenig RJ, Peterson CM, Jones RL, Saudek C, Lehrman M, Cerami A. Correlation of glucose regulation and hemoglobin AIc in diabetes mellitus. N Engl J Med 1976; 295(8): 417-20.
[http://dx.doi.org/10.1056/NEJM197608192950804] [PMID: 934240]
[3]
Yamagishi SI, Matsui T. Role of hyperglycemia-induced advanced glycation end product (AGE) accumulation in atherosclerosis. Ann Vasc Dis 2018; 11(3): 253-8.
[http://dx.doi.org/10.3400/avd.ra.18-00070] [PMID: 30402172]
[4]
Thornalley PJ. The enzymatic defence against glycation in health, disease and therapeutics: a symposium to examine the concept. Biochem Soc Trans 2003; 31(Pt 6): 1341-2.
[http://dx.doi.org/10.1042/bst0311341] [PMID: 14641059]
[5]
Bettiga A, Fiorio F, Di Marco F, et al. The modern western diet rich in advanced glycation end-products (AGEs): an overview of its impact on obesity and early progression of renal pathology. Nutrients 2019; 11(8): 1748.
[http://dx.doi.org/10.3390/nu11081748] [PMID: 31366015]
[6]
Huby R, Harding JJ. Non-enzymic glycosylation (glycation) of lens proteins by galactose and protection by aspirin and reduced glutathione. Exp Eye Res 1988; 47(1): 53-9.
[http://dx.doi.org/10.1016/0014-4835(88)90023-1] [PMID: 3409987]
[7]
Zaman Z, Verwilghen RL. Non-enzymic glycosylation of horse spleen and rat liver ferritins. Biochim Biophys Acta 1981; 669(2): 120-4.
[http://dx.doi.org/10.1016/0005-2795(81)90232-4] [PMID: 7284431]
[8]
Haney DN, Bunn HF. Glycosylation of hemoglobin in vitro: affinity labeling of hemoglobin by glucose-6-phosphate. Proc Natl Acad Sci USA 1976; 73(10): 3534-8.
[http://dx.doi.org/10.1073/pnas.73.10.3534] [PMID: 1068465]
[9]
Wei Y, Chen L, Chen J, Ge L, He RQ. Rapid glycation with D-ribose induces globular amyloid-like aggregations of BSA with high cytotoxicity to SH-SY5Y cells. BMC Cell Biol 2009; 10: 10-7.
[http://dx.doi.org/10.1186/1471-2121-10-10] [PMID: 19216769]
[10]
Acharya AS, Sussman LG, Manning JM. Schiff base adducts of glyceraldehydes with hemoglobin. J Biol Chem 1983; 258: 2296-302.
[PMID: 6822561]
[11]
McKinney RA, Urbanowski JC, Dain JA. Non enzymatic glycosylation of albumin and fetuin by sialic acid. Biochem Int 1982; 4: 127-30.
[12]
Peterson AB, Wulf HC, Guiadecki R, Gajkowska B. Dihydroxyacetone, the active browning ingredient in sunless tanning lotions, induces DNA damage, cell cycle block and apoptosis in cultured HaCaT retinocytes. Mutat Res 2004; 13: 173-86.
[http://dx.doi.org/10.1016/j.mrgentox.2004.03.002]
[13]
Scaloni A, Perillo V, Franco P, et al. Characterization of heat-induced lactosylation products in caseins by immunoenzymatic and mass spectrometric methodologies. Biochim Biophys Acta 2002; 1598(1-2): 30-9.
[http://dx.doi.org/10.1016/S0167-4838(02)00290-X] [PMID: 12147341]
[14]
Semba RD, Nicklett EJ, Ferrucci L. Does accumulation of advanced glycation end products contribute to the aging phenotype? J Gerontol A Biol Sci Med Sci 2010; 65(9): 963-75.
[http://dx.doi.org/10.1093/gerona/glq074] [PMID: 20478906]
[15]
Hanover LM, White JS. Manufacturing, composition, and applications of fructose. Am J Clin Nutr 1993; 58(5)(Suppl.): 724S-32S.
[http://dx.doi.org/10.1093/ajcn/58.5.724S] [PMID: 8213603]
[16]
Park YK, Yetley EA. Intakes and food sources of fructose in the United States. Am J Clin Nutr 1993; 58(5)(Suppl.): 737S-47S.
[http://dx.doi.org/10.1093/ajcn/58.5.737S] [PMID: 8213605]
[17]
Finelli C, Tarantino G. Is there any consensus as to what diet or lifestyle approach is the right one for NAFLD patients? J Gastrointestin Liver Dis 2012; 21(3): 293-302.
[PMID: 23012671]
[18]
Bunn HF, Higgins PJ. Reaction of monosaccharides with proteins: possible evolutionary significance. Science 1981; 213(4504): 222-4.
[http://dx.doi.org/10.1126/science.12192669] [PMID: 12192669]
[19]
Gugliucci A. Formation of fructose-mediated advanced glycation end products and their roles in metabolic and inflammatory diseases. Adv Nutr 2017; 8(1): 54-62.
[http://dx.doi.org/10.3945/an.116.013912] [PMID: 28096127]
[20]
Gabbay KH. Hyperglycemia, polyol metabolism, and complications of diabetes mellitus. Annu Rev Med 1975; 26: 521-36.
[http://dx.doi.org/10.1146/annurev.me.26.020175.002513] [PMID: 238458]
[21]
Kinoshita JHS, Fukushi S, Kador P, Merola LO. Aldose reductase in diabetic complications of the eye. Metabolism 1979; 28(4)(Suppl. 1): 462-9.
[http://dx.doi.org/10.1016/0026-0495(79)90057-X] [PMID: 45423]
[22]
Tomlinson DR, Stevens EJ, Diemel LT. Aldose reductase inhibitors and their potential for the treatment of diabetic complications. Trends Pharmacol Sci 1994; 15(8): 293-7.
[http://dx.doi.org/10.1016/0165-6147(94)90010-8] [PMID: 7940997]
[23]
Kashiwagi A, Obata T, Suzaki M, et al. Increase in cardiac muscle fructose content in streptozotocin-induced diabetic rats. Metabolism 1992; 41(10): 1041-6.
[http://dx.doi.org/10.1016/0026-0495(92)90283-G] [PMID: 1406291]
[24]
Sakasai-Sakai A, Takata T, Suzuki H, Maruyama I, Motomiya Y, Takeuchi M. Immunological evidence for in vivo production of novel advanced glycation end-products from 1,5-anhydro-D-fructose, a glycogen metabolite. Sci Rep 2019; 9(1): 10194.
[http://dx.doi.org/10.1038/s41598-019-46333-2] [PMID: 31308400]
[25]
Neglia CI, Cohen HJ, Garber AR, Ellis PD, Thorpe SR, Baynes JW. 13C NMR investigation of nonenzymatic glucosylation of protein. Model studies using RNase A. J Biol Chem 1983; 258(23): 14279-83.
[PMID: 6643480]
[26]
Wells-Knecht KJ, Zyzak DV, Litchfield JE, Thorpe SR, Baynes JW. Mechanism of autoxidative glycosylation: identification of glyoxal and arabinose as intermediates in the autoxidative modification of proteins by glucose. Biochemistry 1995; 34(11): 3702-9.
[http://dx.doi.org/10.1021/bi00011a027] [PMID: 7893666]
[27]
Ahmed N, Argirov OK, Minhas HS, Cordeiro CAA, Thornalley PJ. Assay of advanced glycation endproducts (AGEs): surveying AGEs by chromatographic assay with derivatization by 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate and application to Nepsilon-carboxymethyl-lysine- and Nepsilon-(1-carboxyethyl)lysine-modified albumin. Biochem J 2002; 364(Pt 1): 1-14.
[http://dx.doi.org/10.1042/bj3640001] [PMID: 11988070]
[28]
Suarez G, Rajaram R. Oronsky Al,Gawinowiez MA. Non enzymatic glycation of bovine serum albumin by fructose (fructation). Comparison with the Maillard reaction initiated by glucose. J Biol Chem 1989; 264: 3674-9.
[PMID: 2537288]
[29]
Wolff SP, Dean RT. Aldehydes and dicarbonyls in non-enzymic glycosylation of proteins. Biochem J 1988; 249(2): 618-9.
[http://dx.doi.org/10.1042/bj2490618] [PMID: 3342033]
[30]
Hunt JV, Dean RT, Wolff SP. Hydroxyl radical production and autoxidative glycosylation. Glucose autoxidation as the cause of protein damage in the experimental glycation model of diabetes mellitus and ageing. Biochem J 1988; 256(1): 205-12.
[http://dx.doi.org/10.1042/bj2560205] [PMID: 2851978]
[31]
Ahmed MU, Thorpe SR, Baynes JW. Identification of N ε-carboxymethyllysine as a degradation product of fructoselysine in glycated protein. J Biol Chem 1986; 261(11): 4889-94.
[PMID: 3082871]
[32]
Wolff SP, Dean RT. Glucose autoxidation and protein modification. The potential role of ‘autoxidative glycosylation’ in diabetes. Biochem J 1987; 245(1): 243-50.
[http://dx.doi.org/10.1042/bj2450243] [PMID: 3117042]
[33]
Burton-Freeman B. Postprandial metabolic events and fruit-derived phenolics: a review of the science. Br J Nutr 2010; 104(Suppl. 3): S1-S14.
[http://dx.doi.org/10.1017/S0007114510003909] [PMID: 20955646]
[34]
Singh VP, Bali A, Singh N, Jaggi AS. Advanced glycation end products and diabetic complications. Korean J Physiol Pharmacol 2014; 18(1): 1-14.
[http://dx.doi.org/10.4196/kjpp.2014.18.1.1] [PMID: 24634591]
[35]
Lorenzi M, Cagliero E, Markey B, Henricksen T, Weitztum JL, Sampietro T. Diabetes 1994; 26: 218-22.
[36]
Seidler NW. Carbonyl induced enzyme inhibition: mechanisms and new perspectives. Curr Enzym Inhib 2005; 1: 21-7.
[http://dx.doi.org/10.2174/1573408052952720]
[37]
Bose T, Chakraborti AS. Fructose-induced structural and functional modifications of hemoglobin: implication for oxidative stress in diabetes mellitus. Biochim Biophys Acta 2008; 1780(5): 800-8.
[http://dx.doi.org/10.1016/j.bbagen.2008.02.001] [PMID: 18339326]
[38]
Cao H, Chen T, Shi Y. Glycation of human serum albumin in diabetes: impacts on the structure and function. Curr Med Chem 2015; 22(1): 4-13.
[http://dx.doi.org/10.2174/0929867321666140912155738] [PMID: 25245514]
[39]
McPherson JD, Shilton BH, Walton DJ. Role of fructose in glycation and cross-linking of proteins. Biochemistry 1988; 27(6): 1901-7.
[http://dx.doi.org/10.1021/bi00406a016] [PMID: 3132203]
[40]
Hoenders HJ, Bloemendal H. Lens proteins and aging. J Gerontol 1983; 38(3): 278-86.
[http://dx.doi.org/10.1093/geronj/38.3.278] [PMID: 6341444]
[41]
Kawasaki Y, Fujii J, Miyazawa N, et al. Specific detections of the early process of the glycation reaction by fructose and glucose in diabetic rat lens. FEBS Lett 1998; 441(1): 116-20.
[http://dx.doi.org/10.1016/S0014-5793(98)01529-4] [PMID: 9877177]
[42]
Yan H, Willis AC, Harding JJ. Gamma III-crystallin is the primary target of glycation in the bovine lens incubated under physiological conditions. Biochem J 2003; 374(Pt 3): 677-85.
[http://dx.doi.org/10.1042/bj20030542] [PMID: 12803541]
[43]
Jairajpuri DS, Fatima S, Saleemuddin M. Immunoglobulin glycation with fructose: A comparative study. Clin Chim Acta 2007; 378(1-2): 86-92.
[http://dx.doi.org/10.1016/j.cca.2006.10.020] [PMID: 17173886]
[44]
Jairajpuri DS, Fatima S, Jairajpuri Z. Glycation induced physicochemical changes in low density lipoprotein and its role in promoting cholesterol accumulation in macrophages along with anti-glycation effect of amino guanidine. Adv Biol Chem 2015; 05: 203-14.
[http://dx.doi.org/10.4236/abc.2015.55017]
[45]
Shoham DA, Durazo-Arvizu R, Kramer H, et al. Sugary soda consumption and albuminuria: Results from the National Health and Nutrition Examination Survey, 1999-2004. PLoS One 2008; 3(10)e3431
[http://dx.doi.org/10.1371/journal.pone.0003431] [PMID: 18927611]
[46]
Arai K, Iizuka S, Tada Y, Oikawa K, Taniguchi N. Increase in the glucosylated form of erythrocyte Cu-Zn-superoxide dismutase in diabetes and close association of the nonenzymatic glucosylation with the enzyme activity. Biochim Biophys Acta 1987; 924(2): 292-6.
[http://dx.doi.org/10.1016/0304-4165(87)90025-0] [PMID: 3567220]
[47]
Kaneto H, Fuji J, Myint T, et al. Beneficial effects of antioxidants in diabetes: possible protection of pancreatic β cells against glucose toxicity. Biochem J 1996; 320: 855-63.
[http://dx.doi.org/10.1042/bj3200855] [PMID: 9003372]
[48]
Takata I, Kawamura N, Myint T, et al. Glycated Cu,Zn-superoxide dismutase in rat lenses: evidence for the presence of fragmentation in vivo. Biochem Biophys Res Commun 1996; 219(1): 243-8.
[http://dx.doi.org/10.1006/bbrc.1996.0212] [PMID: 8619815]
[49]
Takamiya R, Takahashi M, Myint T, et al. Glycation proceeds faster in mutated Cu, Zn-superoxide dismutases related to familial amyotrophic lateral sclerosis. FASEB J 2003; 17(8): 938-40.
[http://dx.doi.org/10.1096/fj.02-0768fje] [PMID: 12626432]
[50]
Yan H, Harding JJ. Glycation-induced inactivation and loss of antigenicity of catalase and superoxide dismutase. Biochem J 1997; 328(Pt 2): 599-605.
[http://dx.doi.org/10.1042/bj3280599] [PMID: 9371721]
[51]
Cavarape A, Feletto F, Mercuri F, Quagliaro L, Daman G, Ceriello A. High-fructose diet decreases catalase mRNA levels in rat tissues. J Endocrinol Invest 2001; 24(11): 838-45.
[http://dx.doi.org/10.1007/BF03343940] [PMID: 11817707]
[52]
Nishikawa T, Edelstein D, Du XL, et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 2000; 404(6779): 787-90.
[http://dx.doi.org/10.1038/35008121] [PMID: 10783895]
[53]
Derham BK, Harding JJ. Enzyme activity after resealing within ghost erythrocyte cells, and protection by alpha-crystallin against fructose-induced inactivation. Biochem J 2002; 368(Pt 3): 865-74.
[http://dx.doi.org/10.1042/bj20020924] [PMID: 12204092]
[54]
Derham BK, Ellory JC, Bron AJ, Harding JJ. The molecular chaperone α-crystallin incorporated into red cell ghosts protects membrane Na/K-ATPase against glycation and oxidative stress. Eur J Biochem 2003; 270(12): 2605-11.
[http://dx.doi.org/10.1046/j.1432-1033.2003.03631.x] [PMID: 12787026]
[55]
Caballero FA, Gerez EN, Polo CF, Vazquez ES, Batlle AMC. Reducing sugars trigger delta-aminolevulinic dehydratase inactivation: evidence of in vitro aspirin prevention. Gen Pharmacol 1998; 31(3): 441-5.
[http://dx.doi.org/10.1016/S0306-3623(98)00016-0] [PMID: 9703216]
[56]
Fatima S, Jairajpuri DS, Saleemuddin M. A procedure for the rapid screening of Maillard reaction inhibitors. J Biochem Biophys Methods 2008; 70(6): 958-65.
[http://dx.doi.org/10.1016/j.jprot.2007.10.002] [PMID: 18096239]
[57]
Blakytny R, Harding JJ. Prevention of the inactivation of glutathione reductase by fructation using human α-crystallin. Biochem Soc Trans 1995; 23(4): 610S.
[http://dx.doi.org/10.1042/bst023610s] [PMID: 8654795]
[58]
Ganea E, Harding JJ. Trehalose and 6-aminohexanoic acid stabilize and renature glucose-6-phosphate dehydrogenase inactivated by glycation and by guanidinium hydrochloride. Biol Chem 2005; 386(3): 269-78.
[http://dx.doi.org/10.1515/BC.2005.032] [PMID: 15843172]
[59]
Heath MM, Rixon KC, Harding JJ. Glycation-induced inactivation of malate dehydrogenase protection by aspirin and a lens molecular chaperone, α-crystallin. Biochim Biophys Acta 1996; 1315(3): 176-84.
[http://dx.doi.org/10.1016/0925-4439(95)00120-4] [PMID: 8611656]
[60]
Yan H, Harding JJ. Carnosine protects against the inactivation of esterase induced by glycation and a steroid. Biochim Biophys Acta 2005; 1741(1-2): 120-6.
[http://dx.doi.org/10.1016/j.bbadis.2004.11.008] [PMID: 15955455]
[61]
Kil IS, Lee JH, Shin AH, Park JW. Glycation-induced inactivation of NADP(+)-dependent isocitrate dehydrogenase: implications for diabetes and aging. Free Radic Biol Med 2004; 37(11): 1765-78.
[http://dx.doi.org/10.1016/j.freeradbiomed.2004.08.025] [PMID: 15528036]
[62]
González Flecha FL, Castello PR, Caride AJ, Gagliardino JJ, Rossi JP. The erythrocyte calcium pump is inhibited by non-enzymic glycation: studies in situ and with the purified enzyme. Biochem J 1993; 293(Pt 2): 369-75.
[http://dx.doi.org/10.1042/bj2930369] [PMID: 8393658]
[63]
Hoshi A, Takahashi M, Fujii J, et al. Glycation and inactivation of sorbitol dehydrogenase in normal and diabetic rats. Biochem J 1996; 318(Pt 1): 119-23.
[http://dx.doi.org/10.1042/bj3180119] [PMID: 8761460]
[64]
Zhao W, Devamanoharan PS, Varma SD. Fructose induced deactivation of antioxidant enzymes: preventive effect of pyruvate. Free Radic Res 2000; 33(1): 23-30.
[http://dx.doi.org/10.1080/10715760000300581] [PMID: 10826918]
[65]
Baynes JW. The Maillard hypothesis on aging: time to focus on DNA. Ann N Y Acad Sci 2002; 959: 360-7.
[http://dx.doi.org/10.1111/j.1749-6632.2002.tb02107.x] [PMID: 11976210]
[66]
Papoulis A, al-Abed Y, Bucala R. Identification of N2-(1-carboxyethyl)guanine (CEG) as a guanine advanced glycosylation end product. Biochemistry 1995; 34(2): 648-55.
[http://dx.doi.org/10.1021/bi00002a032] [PMID: 7819260]
[67]
Ahmad R, Sah AK, Ahsan H. Biochemistry and pathophysiology of glycation of DNA: implication in diabetes. Arch Clin Biomed Res 2016; 1: 32-47.
[http://dx.doi.org/10.26502/acbr.5017004]
[68]
Schneider M, Quistad GB, Casida JE. 1,3-Dichloropropene epoxides: intermediates in bioactivation of the promutagen 1,3-dichloropropene. Chem Res Toxicol 1998; 11(10): 1137-44.
[http://dx.doi.org/10.1021/tx980126y] [PMID: 9778309]
[69]
Bucala R, Model P, Cerami A. Modification of DNA by reducing sugars: a possible mechanism for nucleic acid aging and age-related dysfunction in gene expression. Proc Natl Acad Sci USA 1984; 81(1): 105-9.
[http://dx.doi.org/10.1073/pnas.81.1.105] [PMID: 6582469]
[70]
Lee AT, Plump A, DeSimone C, Cerami A, Bucala R. A role for DNA mutations in diabetes-associated teratogenesis in transgenic embryos. Diabetes 1995; 44(1): 20-4.
[http://dx.doi.org/10.2337/diab.44.1.20] [PMID: 7813809]
[71]
Manikandamathavan VM, Thangaraj M, Weyhermuller T, et al. Novel mononuclear Cu (II) terpyridine complexes: Impact of fused ring thiophene and thiazole head groups towards DNA/BSA interaction, cleavage and antiproliferative activity on HepG2 and triple negative CAL-51 cell line. Eur J Med Chem 2017; 135: 434-46.
[http://dx.doi.org/10.1016/j.ejmech.2017.04.030] [PMID: 28475971]
[72]
Levi B, Werman MJ. Fructose triggers DNA modification and damage in an Escherichia coli plasmid. J Nutr Biochem 2001; 12(4): 235-41.
[http://dx.doi.org/10.1016/S0955-2863(00)00158-3] [PMID: 11287219]
[73]
Levi B, Werman MJ. Fructose and related phosphate derivatives impose DNA damage and apoptosis in L5178Y mouse lymphoma cells. J Nutr Biochem 2003; 14(1): 49-60.
[http://dx.doi.org/10.1016/S0955-2863(02)00254-1] [PMID: 12559477]
[74]
Yamagishi S, Okamoto T, Amano S, et al. Palmitate-induced apoptosis of microvascular endothelial cells and pericytes. Mol Med 2002; 8(4): 179-84.
[http://dx.doi.org/10.1007/BF03402010] [PMID: 12149567]
[75]
Kaji Y, Amano S, Usui T, et al. Expression and function of receptors for advanced glycation end products in bovine corneal endothelial cells. Invest Ophthalmol Vis Sci 2003; 44(2): 521-8.
[http://dx.doi.org/10.1167/iovs.02-0268] [PMID: 12556378]
[76]
Min C, Kang E, Yu SH, Shinn SH, Kim YS. Advanced glycation end products induce apoptosis and procoagulant activity in cultured human umbilical vein endothelial cells. Diabetes Res Clin Pract 1999; 46(3): 197-202.
[http://dx.doi.org/10.1016/S0168-8227(99)00094-7] [PMID: 10624785]
[77]
Wondrak GT, Jacobson EL, Jacobson MK. Photosensitization of DNA damage by glycated proteins. Photochem Photobiol Sci 2002; 1(5): 355-63.
[http://dx.doi.org/10.1039/b202732c] [PMID: 12653475]
[78]
Elmegerhi S, Su C, Buglewicz DJ, Aizawa Y, Kato TA. Effect of hydroxyl group position in flavonoids on inducing single stranded DNA damage mediated by cupric ions. Int J Mol Med 2018; 42(1): 658-64.
[http://dx.doi.org/10.3892/ijmm.2018.3615] [PMID: 29620152]
[79]
Gugliucci A. Advanced glycation of rat liver histone octamers: An in vitro study. Biochem Biophys Res Commun 1994; 203(1): 588-93.
[http://dx.doi.org/10.1006/bbrc.1994.2223] [PMID: 8074708]
[80]
DeChristopher LR, Tucker KL. Excess free fructose, high-fructose corn syrup and adult asthma: The Framingham Offspring Cohort. Br J Nutr 2018; 119(10): 1157-67.
[http://dx.doi.org/10.1017/S0007114518000417] [PMID: 29587887]
[81]
Hannou SA, Haslam DE, McKeown NM, Herman MA. Fructose metabolism and metabolic disease. J Clin Invest 2018; 128(2): 545-55.
[http://dx.doi.org/10.1172/JCI96702] [PMID: 29388924]
[82]
Kuzma JN, Cromer G, Hagman DK, et al. No differential effect of beverages sweetened with fructose, high-fructose corn syrup, or glucose on systemic or adipose tissue inflammation in normal-weight to obese adults: a randomized controlled trial. Am J Clin Nutr 2016; 104(2): 306-14.
[http://dx.doi.org/10.3945/ajcn.115.129650] [PMID: 27357093]
[83]
Mortera RR, Bains Y, Gugliucci A. Fructose at the crossroads of the metabolic syndrome and obesity epidemics. Front Biosci 2019; 24: 186-211.
[http://dx.doi.org/10.2741/4713] [PMID: 30468651]
[84]
Yilmaz Y. Review article: fructose in non-alcoholic fatty liver disease. Aliment Pharmacol Ther 2012; 35(10): 1135-44.
[http://dx.doi.org/10.1111/j.1365-2036.2012.05080.x] [PMID: 22469071]

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