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Current Chemical Biology

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ISSN (Print): 2212-7968
ISSN (Online): 1872-3136

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Review Article

The Role of Heat Shock Protein -90 (HSP-90) in Inflammatory Disorders

Author(s): Chiranjib Bhattacharjee and Lokesh Deb*

Volume 14, Issue 1, 2020

Page: [30 - 37] Pages: 8

DOI: 10.2174/2212796814666200122114833

Abstract

In human cells, Heat Shock Protein-90 (HSP-90) is present in the cytosol, nucleoplasm, endoplasmic reticulum, and mitochondria. The eukaryotic HSP-90 is multifunctionary and essential for cell viability, signal transduction, cell-cycle control as well as transcriptional regulation. The intracellular environment does not restrict HSP-90. It has a vital role in all types of inflammatory disorders, including cancer, autoimmune diseases, infectious inflammatory conditions. Hence, pharmacological inhibition of HSP-90 is currently a choice of therapeutic target for the treatment of autoimmune diseases, cancer, and infectious diseases. Based on the biology of HSP-90, several COOH-terminal ATPase sites of HSP-90, NH2-terminal ATPase sites of HSP-90, and Histone deacetylase inhibitors are evaluated and classified under various groups. For the treatment of different inflammatory disorders, HSP-90 identified as a promising therapeutic target. The present review may guide researchers for evaluating the HSP-90 targeted pathway as a useful therapeutic target for inflammatory diseases, including cancers.

Keywords: Heat shock protein-90 (HSP-90), autoimmune diseases, cancer, HSP inhibitor, viral HSP-90, fungal HSP-90.

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Graphical Abstract

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