TIMP-2 Polymorphisms Define Subtypes of Hypertensive Intracerebral Hemorrhage with Distinct Perihematomal Edema Development Patterns

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Author(s): Ru Chen, Zhi Song*, Wen Zheng, Jia Liu, Lihua Huang, Mingzhu Deng.

Journal Name: Current Neurovascular Research

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Background: Perihematomal edema (PHE) is a major threat leading to poor functional outcomes after Intracerebral hemorrhage (ICH). TIMP-2 is considered to participate in the formation of PHE after ICH by antagonizing the damaging effects of MMP-2. In early study, the polymorphisms of TIMP-2 rs8179090 have shown to influence the expression of TIMP-2.

Objective: To prove that the severity of PHE was different in ICH patients with different TIMP-2 rs8179090 genotypes.

Method: In this prospective study, 130 hypertensive ICH patients were enrolled. The polymorphisms of rs8179090 in TIMP-2 were determined. The hematoma volume and PHE volume were measured by computed tomography (CT) scan immediately after the onset of ICH, and were measured again one week and two weeks after the onset. Then comparison of TIMP-2 rs8179090 genotypes was made.

Result: The TIMP-2 -418 position (rs8179090) had two genotypes in the studied population, GC and GG. Patients with the GC genotype developed more severe PHE, with a higher incidence of delayed cerebral edema in cerebral hemorrhage than those with the GG genotype.

Conclusion: We have found that the GC genotype group may develop more severe PHE, with an increased incidence of delayed cerebral edema in cerebral hemorrhage.

Other: This finding may provide a new predictor for ICH functional outcomes.

Keywords: Hypertensive intracerebral hemorrhage, Perihematomal edema, Polymorphism, TIMP-2, Blood brain barrier, Outcome

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1567202617666191223145632
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