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Combinatorial Chemistry & High Throughput Screening

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ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

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Research Article

Organocatalytic Combinatorial Synthesis of Quinazoline, Quinoxaline and Bis(indolyl)methanes

Author(s): Fatemeh Malamiri, Samad Khaksar*, Rashid Badri and Elham Tahanpesar

Volume 23, Issue 1, 2020

Page: [83 - 88] Pages: 6

DOI: 10.2174/1386207323666191213123026

Price: $65

Abstract

Aims and Objective: An efficient and practical procedure for the synthesis of heterocyclic compounds such as quinazolines, quinoxalines and bis(indolyl)methanes was developed using 3,5-bis(trifluoromethyl) phenyl ammonium hexafluorophosphate (BFPHP) as a novel organocatalyst.

Materials and Methods: All of the obtained products are known compounds and identified by IR, 1HNMR, 13CNMR and melting points.

Result: Various products were obtained in good to excellent yields under reaction conditions.

Conclusion: The BFPHP organocatalyst demonstrates a novel class of non-asymmetric organocatalysts, which has gained much attention in green chemistry.

Keywords: Organocatalyst, green chemistry, quinazoline, multicomponent, heterocyclic, anticancer.

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