The 1,3-dipolar cycloaddition reaction is a powerful and versatile strategy for
the synthesis of carbocyclic and heterocyclic five-membered rings. Herein, the most recent
developments on the [3+2] cycloaddition reactions using allenes acting either as dipolarophiles
or 1,3-dipole precursors, are highlighted. The recent contributions on the
phosphine- and transition metal-catalyzed [3+2] annulations involving allenes as substrates
are also covered, with the exception of those in which the formation of a 1,3-dipole
(or synthetic equivalent) is not invoked.
This review summarizes the most relevant research in which allenes are used as building
blocks for the construction of structurally diverse five-membered rings via [3+2] annulation
Keywords: Allenes, allenoates, annulation, carbocycles, cycloaddition, dipoles, five-membered ring, heterocycles, phosphine catalysis.
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