Natural Fused Heterocyclic Flavonoids: Potent Candidates As Anti-Inflammatory And Anti-Allergic Agents In The Treatment Of Asthma

(E-pub Abstract Ahead of Print)

Author(s): Rajwinder Kaur*, Kirandeep Kaur, Rashmi Arora, Balraj Saini, Sandeep Arora.

Journal Name: Current Bioactive Compounds

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In the last two decades, the flavanoids containing fused heterocyclic nucleus in their chemical structure have emerged to display a variety of pharmacological effects including anti-allergic and anti-inflammatory the most recent to the list. These polyphenolic compounds exert their pharmacological effect by various mechanisms including inhibition of human neutrophil elastase, cytokines (Interleukins- IL-3 and IL-4) and mast cells. Quercetin, Pycnogenol, Rutin and Kampferol are the few bio-flavonols out of hundreds of other compounds still under clinical trials that have been studied most. These flavonoids have been also reported to the other pharmacological effects like anti-cancer, anti-oxidants, anti-hypertensive, anti-viral, anti-ulcerogenic, anti-platelet, anti-hypotensive and anti-hepatotoxic. With all these versatile properties heterocyclic containing flavonoids may be a powerful candidate for the discovery of their utilization in other ailments like asthma.

Keywords: Flavonoids, Asthma, Lawsonia, Thuja orientaliFlavonoids, Thuja orientalis, candidate

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Article Details

(E-pub Abstract Ahead of Print)
DOI: 10.2174/1573407215666191120125608
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