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Current Pharmaceutical Analysis

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ISSN (Print): 1573-4129
ISSN (Online): 1875-676X

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Research Article

Multi-element Quantification in Parenteral Nutrition Mixture by MP-AES and Comparison with ICP-AES

Author(s): Camille Merienne*, Chloe Marchand, Samira Filali, Damien Salmon, Karine Vernoux, Christine Pivot and Fabrice Pirot

Volume 17, Issue 1, 2021

Published on: 15 November, 2019

Page: [159 - 164] Pages: 6

DOI: 10.2174/1573412916666191115152213

Price: $65

Abstract

Background: Individualized parenteral nutrition requires tailor-made preparation in hospital pharmacy followed by suitable quality control, including electrolytic content determination within complex and variable admixtures, containing up to 50 ingredients.

Materials and Methods: An analytical tool has been developed to simultaneously quantify four major electrolytes in parenteral in parenteral nutrition mixtures (i.e., sodium, potassium, magnesium and calcium) using microwave plasma atomic emission spectroscopy (MP-AES). A comparison with reference inducted coupled plasma atomic emission spectroscopy (ICP-AES) was conducted. Calibration standard solutions ranged between 0.2 to 5.0 mg.L-1 for sodium, potassium and calcium and 0.1 to 2.5 mg.L-1 for magnesium. Wavelengths used were respectively 422.6 nm, 517.2 nm, 766.4 nm and 589.5 nm for calcium, magnesium, potassium and sodium, respectively. Accuracy profiles were used for the validation protocol.

Results and Conclusion: The analytical protocol using MP-AES demonstrated high throughput and good sensitivity, thus enabling efficient quality control of manufactured individualized parenteral nutrition mixtures.

Keywords: MP-AES, ICP-AES, parenteral nutrition mixtures, accuracy profile, coupled plasma, microwave plasma.

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[1]
Koletzko, B.; Goulet, O.; Hunt, J.; Krohn, K.; Shamir, R. Parenteral Nutrition Guidelines Working Group. European Society for Clinical Nutrition and Metabolism; European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN); European Society of Paediatric Research (ESPR). 1. Guidelines on Paediatric Parenteral Nutrition of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and the European Society for Clinical Nutrition and Metabolism (ESPEN), Supported by the European Society of Paediatric Research (ESPR). J. Pediatr. Gastroenterol. Nutr., 2005, 41(Suppl. 2), S1-S87.
[http://dx.doi.org/10.1097/01.mpg.0000181841.07090.f4] [PMID: 16254497]
[2]
Marie, N. Analysis of sodium and potassium in total parenteral nutrition bags by icp-ms and icp-aes: critical influence of the ingredients. Am. J. Anal. Chem., 2011, 2(5), 573-581.
[http://dx.doi.org/10.4236/ajac.2011.25065]
[3]
Antes, F.G. Development of multi-elemental method for quality control of parenteral component solutions using ICP-MS. Microchem. J., 2011, 98(1), 144-149.
[http://dx.doi.org/10.1016/j.microc.2010.12.010]
[4]
Nussbaumer, S.; Fleury-Souverain, S.; Bouchoud, L.; Rudaz, S.; Bonnabry, P.; Veuthey, J.L. Determination of potassium, sodium, calcium and magnesium in total parenteral nutrition formulations by capillary electrophoresis with contactless conductivity detection. J. Pharm. Biomed. Anal., 2010, 53(2), 130-136.
[http://dx.doi.org/10.1016/j.jpba.2010.01.042] [PMID: 20172679]
[5]
Karlsson, S.; Sjöberg, V.; Ogar, A. Comparison of MP AES and ICP-MS for analysis of principal and selected trace elements in nitric acid digests of sunflower (Helianthus annuus). Talanta, 2015, 135, 124-132.
[http://dx.doi.org/10.1016/j.talanta.2014.12.015] [PMID: 25640135]
[6]
Method Development for the Determination of Calcium, Copper, Magnesium, Manganese, Iron, Potassium, Phosphorus and Zinc in Different Types of Breads by Microwave Induced Plasma-Atomic Emission Spectrometry - ScienceDirect. accessed, http://www.sciencedirect.com/science/article/pii/S0308814616300450
[7]
Siddiqui, M.R.; AlOthman, Z.A.; Rahman, N. analytical techniques in pharmaceutical analysis: A review. Arab. J. Chem., 2017, 10, S1409-S1421.
[http://dx.doi.org/10.1016/j.arabjc.2013.04.016]
[8]
Hubert, P.; Nguyen-Huu, J.J.; Boulanger, B.; Chapuzet, E.; Chiap, P.; Cohen, N.; Compagnon, P.A.; Dewé, W.; Feinberg, M.; Lallier, M.; Laurentie, M.; Mercier, N.; Muzard, G.; Nivet, C.; Valat, L.; Rozet, E. Harmonization of strategies for the validation of quantitative analytical procedures. A SFSTP proposal--part II. J. Pharm. Biomed. Anal., 2007, 45(1), 70-81.
[http://dx.doi.org/10.1016/j.jpba.2007.06.013] [PMID: 17646076]
[9]
Hubert, P.; Nguyen-Huu, J.J.; Boulanger, B.; Chapuzet, E.; Chiap, P.; Cohen, N.; Compagnon, P.A.; Dewé, W.; Feinberg, M.; Lallier, M.; Laurentie, M.; Mercier, N.; Muzard, G.; Nivet, C.; Valat, L. Harmonization of strategies for the validation of quantitative analytical procedures. A SFSTP proposal--Part I. J. Pharm. Biomed. Anal., 2004, 36(3), 579-586.
[http://dx.doi.org/10.1016/j.jpba.2004.07.027] [PMID: 15522533]
[10]
Hubert, P.; Nguyen-Huu, J.J.; Boulanger, B.; Chapuzet, E.; Cohen, N.; Compagnon, P.A.; Dewé, W.; Feinberg, M.; Laurentie, M.; Mercier, N.; Muzard, G.; Valat, L.; Rozet, E. Harmonization of strategies for the validation of quantitative analytical procedures: a SFSTP proposal part IV. Examples of application. J. Pharm. Biomed. Anal., 2008, 48(3), 760-771.
[http://dx.doi.org/10.1016/j.jpba.2008.07.018] [PMID: 18768284]
[11]
Hammer, M.R. a magnetically excited microwave plasma source for atomic emission spectroscopy with performance approaching that of the inductively coupled plasma. Spectrochim. Acta B At. Spectrosc., 2008, 63(4), 456-464.
[http://dx.doi.org/10.1016/j.sab.2007.12.007]
[12]
Li, W. Microwave plasma-atomic emission spectroscopy as a tool for the determination of copper, iron, manganese and zinc in animal feed and fertilizer. Talanta 112, 2013. 63(Supplement C (August 15, 2013)), 43-48[http://dx.doi.org/10.1016/j.talanta.2013.03.029]

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