Metabolomics and Pharmacological Screening of Aspergillus versicolor Isolated from Hyrtios Erectus Red Sea Sponge; Egypt.

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Author(s): Mohamed Attia Shreadah, Nehad Mohamed Abd El Moneam, Samy A. El-Assar, Asmaa Nabil-Adam*.

Journal Name: Current Bioactive Compounds

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Background: Aspergillus versicolor is a marine-derived fungi isolated from Hyrtios erectus Red Sea sponge. The aim of this study was to carry out a pharmacological screening and investigation for the in vitro biological activity (antioxidant, cholinergic, antidiabetic and anticancer) of Aspergillus versicolor crude extracts active compounds by using different qualitative and quantitative methods.

Results: The present study results showed that Aspergillus versicolor crude extracts contain 0.6 mg total phenolic/mg crude extract. Aspergillus versicolor showed also a potent anioxidative capacity by decreasing the oxidation of ABTS. The anticancer and inhibitory effects of Aspergillus versicolor crude extracts on PTK and SHKI were found to be 75.29 % and 80.76%; respectively. The AChE inhibitory assay revealed that Aspergillus versicolor extracts had an inhibitory percentage of 86.67%. Furthermore, the anti-inflammatory activity using COX1, COX2, TNF, and IL6 were 77.32, 85.21 %, 59.83%, and 56.15%; respectively. Additionally, the anti-viral effect using reverse transcriptase enzyme showed high antiviral activity with 92.10 %.

Conclusion: The current study cleared out that the Aspergillus versicolor crude extract and its active constituents showed strong effects on diminishing the oxidative stress, neurodegenerative damage, anti-inflammatory, anticancer and anti-viral suggesting its beneficial as a promising fermented product in the treatment of cancer, oxidative stress, alzheimer, anti-inflammatory and anti-viral.

Keywords: Hyrtios erectus Red Sea Sponge, Aspergillus versicolor extracts, anti-oxidant, anti-cancer, anti-inflammatory, anti-viral activities

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(E-pub Ahead of Print)
DOI: 10.2174/1573407215666191111122711
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