Background: The treatment of multiple-drug-resistant tuberculosis (MDR-TB) with currently available marketed drugs is still remains a global health concern. The cases of resistant tuberculosis patients are increasing day by day.
Objective: There is a need to develop shorter, simpler and tolerable drug regimens.
Method: In present study, we have synthesized various halo-substituted 2-aryloxyacetohydrazones via series of reactions from halo-substituted phenols. All compounds were characterized by using various spectroscopic methods such as NMR, FT-IR, UV spectroscopy, etc.
Results: All the synthesized hydrazones were showed theoretically good interactions with enzyme enoyl reductase (pdb id: 4tzk). All the synthesized compounds (5a-5o) showed moderate to good activity (3.125-100 µg/mL) against Mycobacteria tuberculosis, H37RV strain.
Conclusion: Our results would definitely pave the new way towards development of more effective Anti-TB agents in future.