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Mini-Reviews in Medicinal Chemistry

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ISSN (Online): 1875-5607

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Review Article

Molecular Mechanisms of the Action of Myricetin in Cancer

Author(s): Yutao Xie, Yunlong Wang*, Wei Xiang, Qiaoying Wang and Yajun Cao

Volume 20, Issue 2, 2020

Page: [123 - 133] Pages: 11

DOI: 10.2174/1389557519666191018112756

Price: $65

Abstract

Natural compounds, such as paclitaxel and camptothecin, have great effects on the treatment of tumors. Such natural chemicals often achieve anti-tumor effects through a variety of mechanisms. Therefore, it is of great significance to conduct further studies on the anticancer mechanism of natural anticancer agents to lay a solid foundation for the development of new drugs. Myricetin, originally isolated from Myrica nagi, is a natural pigment of flavonoids that can inhibit the growth of cancer cells (such as liver cancer, rectal cancer, skin cancer and lung cancer, etc.). It can regulate many intracellular activities (such as anti-inflammatory and blood lipids regulation) and can even be bacteriostatic. The purpose of this paper is to outline the molecular pathways of the anticancer effects of myricetin, including the effect on cancer cell death, proliferation, angiogenesis, metastasis and cell signaling pathway.

Keywords: Myricetin, cancer, anticancer, molecular mechanism, natural, proliferation, angiogenesis.

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