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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Review Article

Biological Production of (S)-acetoin: A State-of-the-Art Review

Author(s): Neng-Zhong Xie*, Jian-Xiu Li and Ri-Bo Huang*

Volume 19, Issue 25, 2019

Page: [2348 - 2356] Pages: 9

DOI: 10.2174/1568026619666191018111424

Price: $65

Abstract

Acetoin is an important four-carbon compound that has many applications in foods, chemical synthesis, cosmetics, cigarettes, soaps, and detergents. Its stereoisomer (S)-acetoin, a high-value chiral compound, can also be used to synthesize optically active drugs, which could enhance targeting properties and reduce side effects. Recently, considerable progress has been made in the development of biotechnological routes for (S)-acetoin production. In this review, various strategies for biological (S)- acetoin production are summarized, and their constraints and possible solutions are described. Furthermore, future prospects of biological production of (S)-acetoin are discussed.

Keywords: (S)-Acetoin, Chiral compound, Whole-cell biocatalyst, In situ cofactor regeneration, Biological production, Side effects.

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