Login Register Cart 0
Generic placeholder image

Current Molecular Medicine

Editor-in-Chief

ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe Translate in Chinese
Research Article

Change in Quality of Life of OSAHS Patients with Minimally Invasive Surgery or CPAP Therapy: A 2-year Retrospective, Single-center Parallel-group Study

Author(s): Xiao-Qing Zhang*, Xin Zhao, Pei-Wei Hong, Jin Zhou, Ping Zeng, Cong Liu, Xiao-ying Li, Yang Zhao and Li-Qiong Jiang

Volume 20, Issue 3, 2020

Page: [231 - 239] Pages: 9

DOI: 10.2174/1566524019666191009150734

open access plus

Abstract

Background: By including untreated obstructive sleep apnea-hypopnea syndrome (OSAHS) patients as the control group, this study explores the influence of minimally invasive surgical treatment and continuous positive airway pressure (CPAP) therapy on OSAHS patients, with the subjective and objective performance. The study also discusses their relationship, determines the effect factor, and provides a simple and practical method for evaluation of clinical efficacy.

Methods: A total of 90 OSAHS patients, who were diagnosed in the Sleep Disorders Diagnosis and Treatment Center of Sichuan Province from May 2014 to May 2016, were selected for the present study. These patients were divided into three groups: surgery group, CPAP group, and untreated group. These patients were followed up at six months, one year, and two years, respectively. The physiological indicators, clinical symptoms, degree of daytime sleepiness and quality of life were compared among these three groups. The daytime sleepiness and the quality of life before and after minimally invasive surgery and CPAP treatment were evaluated, and the subjective and objective efficacy of surgery and CPAP treatment was explored.

Results: Among these 90 patients, 11 (12.2%) patients had hypertension, while two (2.2%) patients had diabetes. The average AHI score was 50.53±23.39 per hour, and the mean minimum oxygen saturation and mean oxygen saturation was 71.25±14.16% and 90.13±5.90%, respectively. There were statistically significant differences in mouth breathing, morning sore throat and daytime sleepiness in the group having received surgery at 0.5 year and one year. In the CPAP group, there were statistically significant differences in mouth breathing, morning sore throat and daytime sleepiness at 0.5 year, one year and two years. Moreover, there were statistically significant differences in memory loss at one year and two years, and there were statistically significant differences in frequent nocturia at one year. The ESS value in the surgery group decreased at 0.5 year and one year, but increased at two years. The situation was the same in terms of the total points and in each dimension of the SF-36 paramter. The delta values of ESS among the three groups had statistical significance at 0.5 year, one year and two years, in which the CPAP group experienced the most changes, followed by the surgery group and the group received health education.

Conclusion: For minimally invasive surgery, CPAP therapy and health education can improve daytime sleepiness and quality of life. CPAP therapy was found to be the most effective, followed by minimally invasive surgery and provision of health education. However, the treatment of OSAHS should be comprehensive.

Keywords: OSAHS, minimally invasive surgery, CPAP, quality of life, sleep disorder, sleep.

« Previous Next »
[1]
Knauert M, Naik S, Gillespie MB, Kryger M. Clinical consequences and economic costs of untreated obstructive sleep apnea syndrome. World J Otorhinolaryngol Head Neck Surg 2015; 1(1): 17-27.
[http://dx.doi.org/10.1016/j.wjorl.2015.08.001] [PMID: 29204536]
[2]
Zamarron C, García Paz V, Riveiro A. Obstructive sleep apnea syndrome is a systemic disease. Current evidence. Eur J Intern Med 2008; 19(6): 390-8.
[http://dx.doi.org/10.1016/j.ejim.2007.12.006] [PMID: 18848171]
[3]
Gonçalves M, Amici R, Lucas R, et al. Sleepiness at the wheel across Europe: a survey of 19 countries. J Sleep Res 2015; 24(3): 242-53.
[http://dx.doi.org/10.1111/jsr.12267] [PMID: 25581328]
[4]
Marin JM, Carrizo SJ, Vicente E, Agusti AGN. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet 2005; 365(9464): 1046-53.
[http://dx.doi.org/10.1016/S0140-6736(05)71141-7] [PMID: 15781100]
[5]
Yaggi HKCJ, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med 2005; 353(19): 2034-41.
[http://dx.doi.org/10.1056/NEJMoa043104] [PMID: 16282178]
[6]
Roure N, Mediano O, Durán-Cantolla J, et al. Differences in clinical and polysomnographic variables between male and female patients with sleep apnea-hypopnea syndrome. Archivos de Bronconeumología (Internet) 2008; 44(12): 685-8.
[http://dx.doi.org/10.1016/S1579-2129(09)60007-0]
[7]
Zhang Q, He QY, Du QY, et al. Epidemiologic study on sleep apnea-hypopnea syndrome by home investigation in Chengde city. Zhonghua Jie He He Hu Xi Za Zhi 2003; 5(26): 273-5.
[8]
van Zeller M, Severo M, Santos AC, Drummond M. 5-years APAP adherence in OSA patients--do first impressions matter? Respir Med 2013; 107(12): 2046-52.
[http://dx.doi.org/10.1016/j.rmed.2013.10.011] [PMID: 24169074]
[9]
BaHammam AS, Alassiri SS, Al-Adab AH, et al.. Long-term compliance with continuous positive airway pressure in Saudi patients with obstructive sleep apnea. A prospective cohort study. Saudi Med J 2015; 36(8): 911-9.
[http://dx.doi.org/10.15537/smj.2015.8.11716] [PMID: 26219440]
[10]
Sommer UJ, Heiser C, Gahleitner C, et al. Tonsillectomy with uvulopalatopharyn-goplasty in obstructive sleep apnea deutsches arzteblatt international. 2016; 113: pp. (1-02). 1-8
[http://dx.doi.org/10.3238/arztebl.2016.0001]
[11]
Liu G, Zhang X-Q. Effect and indications of radiofrequency knife and plasma ablation forthe treatment of obstructive sleep apnea and hypopnea syndrome. Mod Prev Med 2013; 40(8): 1568-70.
[12]
Obstructive sleep apnea syndrome diagnosis and surgical treatment guidelines. Chinese J Otorhinolaryngol Head Neck 2009; 44(2): 95-6.
[13]
Sil A, Barr G. Assessment of predictive ability of Epworth scoring in screening of patients with sleep apnoea. J Laryngol Otol 2012; 126(4): 372-9.
[http://dx.doi.org/10.1017/S0022215111003082] [PMID: 22152589]
[14]
Pataka A, Daskalopoulou E, Kalamaras G, Fekete Passa K, Argyropoulou P. Evaluation of five different questionnaires for assessing sleep apnea syndrome in a sleep clinic. Sleep Med 2014; 15(7): 776-81.
[http://dx.doi.org/10.1016/j.sleep.2014.03.012] [PMID: 24891079]
[15]
Huai-Juan W, Xiao-Qing Z. The prediction of epworth sleepiness scale in different occupations of obstructive sleep apnea-hypopnea syndrome. Mod Prev Med 2009; 36(16): 3022-4.
[16]
Wen L, Xiao-Qing Z. The application value of epworth sleepiness scale to screen obstructive sleep apnea hypopnea syndrome patients in mental workers. Mod Prev Med 2011; 38(24): 5057-9.
[17]
Ziebland S. The short form 36 health status questionnaire: clues from the Oxford region’s normative data about its usefulness in measuring health gain in population surveys. J Epidemiol Community Health 1995; 49(1): 102-5.
[http://dx.doi.org/10.1136/jech.49.1.102] [PMID: 7706993]
[18]
Shen Y. Development and psychometric tests of a Chinese version of the SF-36 health survey scales. Chin J Prev Med 2002; 36(2): 109-13.
[19]
Lin HC, Friedman M, Chang HW, Gurpinar B. The efficacy of multilevel surgery of the upper airway in adults with obstructive sleep apnea/hypopnea syndrome. Laryngoscope 2008; 118(5): 902-8.
[http://dx.doi.org/10.1097/MLG.0b013e31816422ea] [PMID: 18300704]
[20]
Weaver TE, Grunstein RR. Adherence to continuous positive airway pressure therapy: the challenge to effective treatment. Proc Am Thorac Soc 2008; 5(2): 173-8.
[http://dx.doi.org/10.1513/pats.200708-119MG] [PMID: 18250209]
[21]
Fujita S, Conway W, Zorick F, Roth T. Surgical correction of anatomic azbnormalities in obstructive sleep apnea syndrome: uvulopalatopharyngoplasty. Otolaryngol Head Neck Surg 1981; 89(6): 923-34.
[http://dx.doi.org/10.1177/019459988108900609] [PMID: 6801592]
[22]
Meccariello G, Cammaroto G, Montevecchi F, et al. Transoral robotic surgery for the management of obstructive sleep apnea: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol 2017; 274(2): 647-53.
[23]
Hou J, Yan J, Wang B, et al. Treatment of obstructive sleep apnea-hypopnea syndrome with combined uvulopalato-pharyngoplasty and midline glossectomy: outcomes from a 5-year study. Respir Care 2012; 57(12): 2104-10.
[http://dx.doi.org/10.4187/respcare.01695] [PMID: 22709822]
[24]
Tanyeri H, Polat S, Kirisoglu CE, Serin GM. Long-term efficacy of submucosal uvulopalatopharyngoplasty for obstructive sleep apnea syndrome European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies 2012; 269: 2069-74.
[http://dx.doi.org/10.1007/s00405-011-1919-x]
[25]
Salapatas AM, Bonzelaar LB, Hwang MS, et al. Impact of minimally invasive multilevel surgery on mild/moderate OSA. Otolaryngol Head Neck Surg 2016; 155(4): 695-701.
[http://dx.doi.org/10.1177/0194599816651240] [PMID: 27301900]
[26]
Ahn SH, Kim JH, Kim DU, Choo IS, Lee HJ, Kim HW. Interaction between sleep-disordered breathing and acute ischemic stroke. J Clin Neurol 2013; 9(1): 9-13.
[http://dx.doi.org/10.3988/jcn.2013.9.1.9] [PMID: 23346154]
[27]
Nam H, Yang HJ, Kim YA, Kim HC. Impact of chronic simulated snoring on carotid atherosclerosis in rabbits. J Clin Neurol 2013; 9(4): 269-73.
[http://dx.doi.org/10.3988/jcn.2013.9.4.269] [PMID: 24285969]

Rights & Permissions Print Cite
Article Metrics
35
2
World Malaria Day
© 2024 Bentham Science Publishers | Privacy Policy