Curcumin - A Novel Therapeutic Agent in the Prevention of Colorectal Cancer

(E-pub Ahead of Print)

Author(s): Manoj Kumar Gupta, Ramakrishna Vadde, Vemula Sarojamma*.

Journal Name: Current Drug Metabolism


Abstract:

Background: Colorectal cancer is the third important cause of cancer-associated deaths across the world. Hence, there is an urgent need for understanding complete mechanism associated with colorectal cancer, which in turn can be utilised toward early detection as well as treatment of colorectal cancer in human. Though colorectal cancer is a complex process and chemotherapy is the first step toward the treatment of colorectal cancer, recently several studies suggested that dietary phytochemicals may also aid significantly in reducing colorectal cancer risk in human. However, only few phytochemicals, specifically curcumin derived from the rhizomes of Curcuma longa, have better chemotherapeutic property, which might be because of its ability to regulate the activity of key factors associated with the initiation, promotion, as well as progression of tumours.

Objectives: In the present review, the authors made an attempt to summarize the physiochemical properties of curcumin, which in turn prevent colorectal cancer via regulating numerous cell signalling as well as genetic pathways.

Conclusions: Accumulated evidence suggested that curcumin suppresses tumour/colon cancer through various ways, (a) restricting cell cycle progression, or stimulating apoptosis, (b) restricting angiogenesis, anti-apoptotic proteins expression, cell survival signalling pathways & their cross-communication and (c) regulating immune responses. The information discussed in the present review will be useful in the drug discovery process as well as the treatment and prevention of colorectal cancer in human.

Keywords: Colorectal cancer, curcumin, anti-cancer, apoptosis, Wnt signalling pathway

Rights & PermissionsPrintExport Cite as


Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1389200220666191007153238
Price: $95

Article Metrics

PDF: 4