Ionic Liquids with Anti-Candida and Anticancer Dual Activity as Potential N-Myristoyltransferase Inhibitors

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Author(s): Larysa Metelytsia, Maria Trush, Ivan Semenyuta, Sergiy Rogalsky, Oleksandr Kobzar, Larisa Kalashnikova, Volodymyr Blagodatnyi, Diana Hodyna*.

Journal Name: Current Bioactive Compounds

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Abstract:

Background: Currently, a study of the relationship between candidiasis and cancer is actual. Until recent years, the opportunistic fungus C. albicans is mainly associated with cancer processes and is able to stimulate carcinogenesis and metastasis.

Methods: A number of ionic liquids as potential anticancer and anti-Candida agents have been investigated based on modern theoretical and experimental data about the relationship between oncopathology and candida infection.

Results: The analysis of the received experimental results demonstrates that ionic liquid with alkyl chain length 6 carbon atoms (C6) haven't shown anti-Candida activity. The indicators of its cytotoxicity ІС50 (28,617µМ) and MTC (9,050 µМ) against HEP-2 tumor cell line were also very low. Compounds with alkyl chain length C12 have shown the high potential of anti-Candida activity and anticancer properties.

Conclusion: Based on the obtained results, сompound 4 (C12C1IM-Cl) is proposed for further study as a potential double acting agent with high anticancer and anti-Candida activities. N-myristoyltransferase is presented and used for docking as a potential molecular target responsible for the dual anti-Сandidа and anticancer activities of studied ionic liquids.

Keywords: Ionic liquids, N-myristoyltransferase, docking, anticancer, anti-Candida

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1573407215666191007120402
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