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Mini-Reviews in Organic Chemistry

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ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

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Review Article

Novel Ketosynthases Catalyzing the Non-Decarboxylative Claisen Condensation

Author(s): Lixia Pan and Dengfeng Yang*

Volume 17, Issue 2, 2020

Page: [169 - 175] Pages: 7

DOI: 10.2174/1570193X16666191002155136

Price: $65

Abstract

In this review, we present the recent advances in unusual novel ketosynthases catalyzing the non-decarboxylative Claisen condensations, including CsyB, MxnB/CorB, Ppys and StlD. The differences are summarized between these non-decarboxylative ketosynthases and the typical decarboxylative ketosynthases. Furthermore, the detailed enzymatic characteristics, structural basis, and catalytic mechanismof these novel ketosynthasesare described. Finally, the prospect of these kind of ketosynthases is discussed.

Keywords: Catalytic mechanism, claisen condensation, condensation reaction head-to-head condensation, novel ketosynthases, polyketide synthase, decarboxylative enzymes.

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