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Current Molecular Medicine

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ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

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Review Article

The Effects of Cholesterol Metabolism on Follicular Development and Ovarian Function

Author(s): Qin Huang, Yannan Liu, Zhen Yang, Yuanjie Xie and Zhongcheng Mo*

Volume 19, Issue 10, 2019

Page: [719 - 730] Pages: 12

DOI: 10.2174/1566524019666190916155004

Price: $65

Abstract

Cholesterol is an important substrate for the synthesis of ovarian sex hormones and has an important influence on follicular development. The cholesterol in follicular fluid is mainly derived from plasma. High-density lipoprotein (HDL) and lowdensity lipoprotein (LDL) play important roles in ovarian cholesterol transport. The knockout of related receptors in the mammalian HDL and LDL pathways results in the reduction or absence of fertility, leading us to support the importance of cholesterol homeostasis in the ovary. However, little is known about ovarian cholesterol metabolism and the complex regulation of its homeostasis. Here, we reviewed the cholesterol metabolism in the ovary and speculated that regardless of the functioning of cholesterol metabolism in the system or the ovarian microenvironment, an imbalance in cholesterol homeostasis is likely to have an adverse effect on ovarian structure and function.

Keywords: Ovarian follicles, lipoprotein, sterol carrier protein 2, steroidogenesis, cholesterol homeostasis, fertility.

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