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Current Pharmaceutical Analysis

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ISSN (Print): 1573-4129
ISSN (Online): 1875-676X

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Research Article

Voltammetric Method Development for Itopride Assay in a Pharmaceutical Formulation

Author(s): Abdulaziz N. Amro*

Volume 16, Issue 3, 2020

Page: [312 - 318] Pages: 7

DOI: 10.2174/1573412915666190912122421

Price: $65

Abstract

Background: Itopride used for the gastrointestinal symptoms caused by reduced gastrointestinal mobility. For the first time rapid, low cost and green voltammetric method has been applied to analyze itopride in pharmaceutical formulation.

Methods: Cyclic Voltammetry (CV), Linear Sweep Voltammetry (LSV), Square Wave Voltammetry (SWV) and Differential Pulse Voltammetry (DPV) methods have been applied in this study.

Results: Na2SO4 (1M) supporting electrolyte exhibited sharper anodic peak current than other used supporting electrolytes; glassy carbon electrode (GC) working electrode shows better results than platinum electrode (Pt). SWV results show the lowest limit of detection and quantitation values of 2.3 and 18.1 μg.mL-1, respectively. SWV recovery is 100.56% and 100.46% for 50 μg.mL-1 and 100 μg.mL-1 of commercially available itopride tablets, respectively. Furthermore, SWV inter and intraday results precessions are better than other used methods with 0.96 and 0.56% RSD, respectively.

Conclusion: The optimum method of applied methods in this study is SWV method. Voltammetry showed low LOD and LOQ values with high accuracy and precession in addition to comparable repeatability and reproducibility values.

Keywords: Itopride, cyclic voltammetry, linear sweep voltammetry, square wave voltammetry, differential pulse voltammetry, chromatographic.

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[1]
Ayak, R.S.; Chaturvedi, S.C. Simultaneous Spectrophotometric Estimation of Rabeprazole Sodium and Itopride HCl. Anal. Lett., 2007, 40, 2288-2294.
[http://dx.doi.org/10.1080/00032710701567139]
[2]
Siddique, M.R.; Alothman, Z.A.; Rahman, N. Analytical techniques in pharmaceutical analysis: A review. Arab. J. Chem., 2017, 10, s1409-s14021.
[http://dx.doi.org/10.1016/j.arabjc.2013.04.016]
[3]
Gupta, V.K.; Jain, R.; Radhapyari, K.; Jadon, N.; Agarwal, S. Voltammetric techniques for the assay of pharmaceuticals--a review. Anal. Biochem., 2011, 408(2), 179-196.
[http://dx.doi.org/10.1016/j.ab.2010.09.027] [PMID: 20869940]
[4]
Fedder, M.; Amro, A.; Bin Oun, S. Voltammetric determination of vildagliptin in a pharmaceutical formulation. Trop. J. Pharm. Res., 2018, 17(9), 1847-1852.
[http://dx.doi.org/10.4314/tjpr.v17i9.24]
[5]
Fedder, M.; Amro, A.; Bin Oun, S.; Ratrout, S.; Asfour, F. Voltammetric Determination of Glycopyrrolate in a pharmaceutical formulation. Turk. J. Chem., 2018, 42, 1736-1743.
[http://dx.doi.org/10.3906/kim-1801-37]
[6]
Kim, Y.S.; Kim, T.H.; Choi, C.S.; Shon, Y.W.; Kim, S.W.; Seo, G.S.; Nah, Y.H.; Choi, M.G.; Choi, S.C. Effect of itopride, a new prokinetic, in patients with mild GERD: a pilot study. World J. Gastroenterol., 2005, 11(27), 4210-4214.
[http://dx.doi.org/10.3748/wjg.v11.i27.4210] [PMID: 16015691]
[7]
Katagiri, F.; Shiga, T.; Inoue, S.; Sato, Y.; Itoh, H.; Takeyama, M. Effects of itopride hydrochloride on plasma gut-regulatory peptide and stress-related hormone levels in healthy human subjects. Pharmacology, 2006, 77(3), 115-121.
[http://dx.doi.org/10.1159/000093485] [PMID: 16717477]
[8]
Ma, J.; Yuan, L.H.; Ding, M.J.; Zhang, J.; Zhang, Q.; Xu, Q.W.; Zhou, X.M. Determination of itopride hydrochloride in human plasma by RP-HPLC with fluorescence detection and its use in bioequivalence study. Pharmacol. Res., 2009, 59(3), 189-193.
[http://dx.doi.org/10.1016/j.phrs.2008.11.007] [PMID: 19101632]
[9]
Khan, A.; Iqbal, Z.; Khadra, I.; Ahmad, L.; Khan, A.; Khan, M.I.; Ullah, Z.; Ismail, Simultaneous determination of domperidone and Itopride in pharmaceuticals and human plasma using RP-HPLC/UV detection: Method development, validation and application of the method in in-vivo evaluation of fast dispersible tablets. J. Pharm. Biomed. Anal., 2016, 121, 6-12.
[http://dx.doi.org/10.1016/j.jpba.2015.12.036] [PMID: 26773534]
[10]
Harun Rasheed, S.; Ramakotaiah, M. ravi kumar, K.; Nagabhushanam C. H.; Prasada, C.H.M.M., Estimation of Rabeprazole Sodium and Itopride Hydrochloride in Tablet Dosage Form Using Reverse Phase High Performance Liquid Chromatography. E-J. Chem., 2011, 8(1), 37-42.
[http://dx.doi.org/10.1155/2011/683845]
[11]
Pillai, S.; Singhvi, I. Quantitative estimation of itopride hydrochloride and rabeprazole sodium from capsule formulation. Indian J. Pharm. Sci., 2008, 70(5), 658-661.
[http://dx.doi.org/10.4103/0250-474X.45411] [PMID: 21394269]
[12]
Thiruvengada Rajan, V.S.; Mohamed Saleem, T.S.; Ramkanth, S.; Alagusundaram, M.; Ganaprakash, K.; Madhusudhana, C. Simple RPHPLC Method for Quantitation of Itopride HCl in Tablet Dosage Form Journal of Young Pharmacists. 2(4), 410-413.
[13]
Suganthi, A.; John, S.; Ravi, T.K. 2008. Simultaneous HPTLC determination of rabeprazole and itopride hydrochloride from their combined dosage form. J. Pharm. Sci., 2010, 70(3), 366-368.
[14]
Sun, Y.; Zhang, Z.; Xi, Z.; Shi, Z.; Tian, W. Determination of itopride hydrochloride by high-performance liquid chromatography with Ru(bpy)3(2+) electrogenerated chemiluminescence detection. Anal. Chim. Acta, 2009, 648(2), 174-177.
[http://dx.doi.org/10.1016/j.aca.2009.07.003] [PMID: 19646581]
[15]
Gupta, K.R.; Chawla, R.B.; Wadodkar, S.G. Stability indicating RP-HPLC method for simultaneous determination of pantoprazole sodium and itopride hydrochloride in bulk and capsule. Orbital Electronic Journal of Chemistry, Campo Grande, 2010, 2(3), 209-224.
[16]
Lee, H.W.; Seo, J.H.; Choi, S.K.; Lee, K.T. Determination of itopride in human plasma by liquid chromatography coupled to tandem mass spectrometric detection: application to a bioequivalence study. Anal. Chim. Acta, 2007, 583(1), 118-123.
[http://dx.doi.org/10.1016/j.aca.2006.09.061] [PMID: 17386535]
[17]
Ragab, M.T.; Abd El-Rahman, M.K.; Ramadan, N.K.; El-Ragehy, N.A.; El-Zeany, B.A. Novel potentiometric application for the determination of pantoprazole sodium and itopride hydrochloride in their pure and combined dosage form. Talanta, 2015, 138, 28-35.
[http://dx.doi.org/10.1016/j.talanta.2015.01.045] [PMID: 25863367]
[18]
Hun, X.; Zhang, Z. Electrogenerated chemiluminescence sensor for itopride with Ru(bpy)32+ doped silica nanoparticles/chitosan composite films modified electrode. Sens. Actuators B Chem., 2008, 131, 403-410.
[http://dx.doi.org/10.1016/j.snb.2007.11.055]
[19]
Gupta, K.R.; Joshi, R.R.; Chawla, R.B.; Wadodkar, S.G. UV Spectrophotometric method for the estimation of itopride hydrochloride in pharmaceutical formulation. E-J. Chem., 2010, 7, S49-S54.
[http://dx.doi.org/10.1155/2010/526891]
[20]
Ramadan, N.K.; El-Ragehy, N.A.; Ragab, M.T.; El-Zeany, B.A. Simultaneous determination of a binary mixture of pantoprazole sodium and itopride hydrochloride by four spectrophotometric methods. Spectrochim. Acta A Mol. Biomol. Spectrosc., 2015, 137, 463-470.
[http://dx.doi.org/10.1016/j.saa.2014.09.003] [PMID: 25238185]
[21]
Sabnis, S.S.; Dhavale, N.D.; Jadhav, V.Y.; Gandhi, S.V. Spectrophotometric simultaneous determination of rabeprazole sodium and itopride hydrochloride in capsule dosage form. Spectrochim. Acta A Mol. Biomol. Spectrosc., 2008, 69(3), 849-852.
[http://dx.doi.org/10.1016/j.saa.2007.05.048] [PMID: 17604217]

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