Cyclodextrin-Based Nanosystems as Drug Carriers for Cancer Therapy

(E-pub Ahead of Print)

Author(s): Ponnurengam Malliappan Sivakumar, Shohreh Peimanfard, Ali Zarrabi*, Arezoo Khosravi, Matin Islami.

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

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Background and Objective: Cyclodextrins have been of great interest as excellent candidate s for fabricating versatile nano drug delivery systems due to their commercial availability, easy functionalization, low immunogenicity, biocompatibility and safety. The possibility of reversible inclusion complex formation between cyclodextrins and various guest molecules in association with versatile exclusive properties of cyclodextrins offer a route towards the fabrication of highly sophisticated nanostructures with enormous potential for cancer treatment.

Methods: The current review will discuss important recent advances in the fabrication and development of cyclodextrin-based nanostructures for cancer therapy. First, formation of inclusion complexes between cyclodextrin derivatives and anticancer compounds as well as their application are summarized. At the end, the future perspective of this field will be discussed.

Results: The cyclodextrins -based nanosystems including cyclodextrin-containing polymers, cyclodextrin-based supramolecular necklaces which consist of polyrotaxanes and polypseudorotaxanes and cyclodextrin based hydrogels are considered as the promising nanosystems in cancer treatment.

Conclusion: The numerous investigations in this area pave the way for the flourishing of the next generation of nano-therapeutics towards the enhanced cancer therapy.

Keywords: Cyclodextrin, nanosystem, cancer therapy, drug delivery, polyrotaxane, polypseudorotaxane, hydrogel

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1871520619666190906160359
Price: $95