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Mini-Reviews in Organic Chemistry

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ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

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Review Article

para-Aminobenzoic Acid-A Substrate of Immense Significance

Author(s): Zaib Un Nisa and Tashfeen Akhtar*

Volume 17, Issue 6, 2020

Page: [686 - 700] Pages: 15

DOI: 10.2174/1570193X16666190828201234

Price: $65

Abstract

PABA (p-aminobenzoic acid) is an important substrate for the synthesis of various biological scaffolds. Its pharmacological significance is apparent form the drugs like folic acid and benzocaine, which are used for certain biological disorders. Although, it is not a vitamin but still it is referred as a member of vitamin B. The deficiency of PABA leads to several disorders like erratic white areas of skin, grey hair, fatigue, depression and irritability. Besides its medicinal importance, PABA has been used in the synthesis of various biologically active heterocyclic nuclei like benzimidazoles, azitidinones, thiazolidinones, pyrazoline, etc. This review will describe the applications of PABA in the synthesis of these biologically active nuclei and hence emphasizing its importance as a versatile substrate.

Keywords: Amino benzoic acid, azetidinone, diazoles, folic acid, natural products, imidazoles.

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