Aging is an inevitable process that involves changes across life in multiple neurochemical,
neuroanatomical, hormonal systems, and many others. In addition, these biological modifications
lead to an increase in age-related sickness such as cardiovascular diseases, osteoporosis, neurodegenerative
disorders, and sleep disturbances, among others that affect activities of daily life.
Demographic projections have demonstrated that aging will increase its worldwide rate in the coming
years. The research on chronic diseases of the elderly is important to gain insights into this
growing global burden. Novel therapeutic approaches aimed for treatment of age-related pathologies
have included the endocannabinoid system as an effective tool since this biological system
shows beneficial effects in preclinical models. However, and despite these advances, little has been
addressed in the arena of the endocannabinoid system as an option for treating sleep disorders in
aging since experimental evidence suggests that some elements of the endocannabinoid system
modulate the sleep-wake cycle. This article addresses this less-studied field, focusing on the likely
perspective of the implication of the endocannabinoid system in the regulation of sleep problems
reported in the aged. We conclude that beneficial effects regarding the putative efficacy of the endocannabinoid
system as therapeutic tools in aging is either inconclusive or still missing.
Keywords: Cannabidiol, childhood, pharmacology, sleep, rapid eye movement sleep, Aging.
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