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Current Cardiology Reviews

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ISSN (Print): 1573-403X
ISSN (Online): 1875-6557

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Review Article

SGLT2 Inhibitors and Cardiovascular Outcomes: Do They Differ or There is a Class Effect? New Insights from the EMPA-REG OUTCOME trial and the CVD-REAL Study

Author(s): Georgios Kyriakos, Lourdes V. Quiles-Sanchez, Anna Garmpi, Paraskevi Farmaki*, Konstantina Kyre, ">Spyridon Savvanis, Vasileios K. Antoniou and Eleni Memi

Volume 16, Issue 4, 2020

Page: [258 - 265] Pages: 8

DOI: 10.2174/1573403X15666190730094215

Price: $65

Abstract

A new group of hypoglycemic drugs has been used to treat diabetes type 2. This group is active sodium glucose co-transporter (SGLT2) or SGLT2 inhibitors. It has been shown that besides the treatment of diabetes, this drug class is responsible for the mildness of the cardiovascular events shown in patients with diabetes type 2. However, there is an intriguing question regarding the range of SGLT2 inhibitors and if there is a difference between them or if there is a class effect among their results. EMPA-REG OUTCOME trial and the CVD-study are used to answer this question. Additional information from the DECLARE-TIMI 58 and Dapa-HF trials is studied.

Keywords: SGLT2 inhibitors, T2DM, diabetes type 2 mellitus, EMPA-REG OUTCOME trial, CVD-REAL study, class effect, cardiovascular events.

Graphical Abstract

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