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Drug Metabolism Letters

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Review Article

Prominence of Oxidative Stress in the Management of Anti-tuberculosis Drugs Related Hepatotoxicity

Author(s): Preena John and Pravin P. Kale*

Volume 13, Issue 2, 2019

Page: [95 - 101] Pages: 7

DOI: 10.2174/1872312813666190716155930

Abstract

Advanced medical services and treatments are available for treating Tuberculosis. Related prevalence has increased in recent times. Unfortunately, the continuous consumption of related drugs is also known for inducing hepatotoxicity which is a critical condition and cannot be overlooked. The present review article has focused on the pathways causing these toxicities and also the role of enzyme CYP2E1, hepatic glutathione, Nrf2-ARE signaling pathway, and Membrane Permeability Transition as possible targets which may help in preventing the hepatotoxicity induced by the drugs used in the treatment of tuberculosis.

Keywords: Isoniazid, rifampicin, hepatotoxicity, oxidative stress, anti-tuberculosis drugs, pharmacology.

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