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Current Diabetes Reviews

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ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

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Systematic Review Article

Pulmonary Pathology Among Patients with Type 2 Diabetes Mellitus: An Updated Systematic Review and Meta-analysis

Author(s): Minaxi Saini*, Sivachidambaram Kulandaivelan, Virender Kumar Bansal, Vikram Saini, Suresh Sharma, Jaspreet Kaur and Aparajita Sondh

Volume 16, Issue 7, 2020

Page: [759 - 769] Pages: 11

DOI: 10.2174/1573399815666190716130324

Price: $65

Abstract

Background: Restrictive lung pathology was reported in the previous meta-analysis among patients with Type 2 Diabetes mellitus (T2DM) which is date back to 2010.

Objective: To see the effect of T2DM on pulmonary functions through updated systematic review and meta-analysis.

Data source: PubMed.

Study Eligibility Criteria: English language case-control or cross-sectional studies, published between 1 January 2010 to 31 August 2018.

Participants and Intervention: T2DM and non-diabetic subjects were compared for at least one of the pulmonary function variables i.e. Forced expiratory volume in 1st second (FEV1), % FEV1, Forced vital capacity (FVC), % FVC and % FEV1/FVC.

Study Appraisal and Synthesis Methods: Methodological quality of the study was assessed using Newcastle-Ottawa Quality Assessment Scale. Meta-analysis was done using Review Manager 5.3 (RevMan 5.3) and meta-regression was conducted using R statistical software.

Results: We selected 22 articles that met our inclusion and exclusion criteria. Results reveal that among patients with T2DM all variables were reduced except %FEV1/FVC which shows statistically nonsignificant results with P=0.46. This confirms that T2DM patients have a restrictive type of lung pathology.

Limitation: Only articles from the PubMed database were included.

Conclusion and Implications of Key Findings: This review affirms the existing evidence of restrictive pathology among patients with T2DM. The future study could be conducted to see the effect of various rehabilitation protocols on pulmonary function among patients with T2DM.

Keywords: Pulmonary function test, type 2 diabetes mellitus, meta-analysis, systematic review, forced expiratory volume, forced vital capacity, cross-sectional studies.

[1]
Unnikrishnan R, Pradeepa R, Joshi SR, Mohan V. Type 2 diabetes: Demystifying the global epidemic. Diabetes 2017; 66(6): 1432-42.
[http://dx.doi.org/10.2337/db16-0766] [PMID: 28533294]
[2]
Pagano E, De Rosa M, Rossi E, et al. The relative burden of diabetes complications on healthcare costs: The population-based CINECA-SID ARNO Diabetes Observatory. Nutr Metab Cardiovasc Dis 2016; 26(10): 944-50.
[http://dx.doi.org/10.1016/j.numecd.2016.05.002] [PMID: 27289165]
[3]
Litwak L, Goh S, Hussein Z, Malek R, Prusty V, Khamseh ME. Prevalence of diabetes complications in people with type 2 diabetes mellitus and its association with baseline characteristics in the multinational A 1 chieve study. Diabetol Metab Syndr 2013; 5(1): 1-10.
[http://dx.doi.org/10.1186/1758-5996-5-57] [PMID: 23298687]
[4]
Pitocco D, Fuso L, Conte EG, et al. The diabetic lung--a new target organ? Rev Diabet Stud 2012; 9(1): 23-35.
[http://dx.doi.org/10.1900/RDS.2012.9.23] [PMID: 22972442]
[5]
Goldman MD. Lung dysfunction in diabetes. Diabetes Care 2003; 26(6): 1915-8.
[http://dx.doi.org/10.2337/diacare.26.6.1915] [PMID: 12766133]
[6]
Klein OL, Krishnan JA, Glick S, Smith LJ. Systematic review of the association between lung function and Type 2 diabetes mellitus. Diabet Med 2010; 27(9): 977-87.
[http://dx.doi.org/10.1111/j.1464-5491.2010.03073.x] [PMID: 20722670]
[7]
Gläser S, Krüger S, Merkel M, Bramlage P, Herth FJF. Chronic obstructive pulmonary disease and diabetes mellitus: a systematic review of the literature. Respiration 2015; 89(3): 253-64.
[http://dx.doi.org/10.1159/000369863] [PMID: 25677307]
[8]
van den Borst B, Gosker HR, Zeegers MP, Schols AMWJ. Pulmonary function in diabetes: a metaanalysis. Chest 2010; 138(2): 393-406.
[http://dx.doi.org/10.1378/chest.09-2622] [PMID: 20348195]
[9]
Rayner L, McGovern A, Creagh-Brown B, Woodmansey C, de Lusignan S. Type 2 Diabetes and Asthma: Systematic Review of the Bidirectional Relationship. Curr Diabetes Rev 2019; 15(2): 118-26.
[http://dx.doi.org/10.2174/1573399814666180711114859] [PMID: 29992891]
[10]
De Santi F, Zoppini G, Locatelli F, et al. Type 2 diabetes is associated with an increased prevalence of respiratory symptoms as compared to the general population. BMC Pulm Med 2017; 17(1): 101.
[http://dx.doi.org/10.1186/s12890-017-0443-1] [PMID: 28716044]
[11]
Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 2009; 151(4): 264-9. W64
[http://dx.doi.org/10.7326/0003-4819-151-4-200908180-00135] [PMID: 19622511]
[12]
Wells G, Shea B, O’Connell D, et al. Ottawa Hospital Research Institute 2013.http://www.ohri.ca/programs/ clinical_epidemiology/oxford.asp
[13]
Agarwal AS, Fuladi AB, Mishra G, Tayade BO. Spirometry and diffusion studies in patients with type-2 diabetes mellitus and their association with microvascular complications. Indian J Chest Dis Allied Sci 2010; 52(4): 213-6.
[PMID: 21302598]
[14]
S A, S M, P G, C R. Alveolar Gas Exchange and Pulmonary Functions in Patients with Type II Diabetes Mellitus. J Clin Diagn Res 2013; 7(9): 1874-7.
[http://dx.doi.org/10.7860/JCDR/2013/6550.3339] [PMID: 24179886]
[15]
Aparna A. Pulmonary function tests in type 2 diabetics and non-diabetic people -a comparative study. J Clin Diagn Res 2013; 7(8): 1606-8.
[PMID: 24086852]
[16]
Dharwadkar AR, Dharwadkar AA, Banu G, Bagali S. Reduction in lung functions in type-2 diabetes in Indian population: correlation with glycemic status. Indian J Physiol Pharmacol 2011; 55(2): 170-5.
[PMID: 22319899]
[17]
Francisco CO, Catai AM, Moura-Tonello SCG, et al. Cardiorespiratory fitness, pulmonary function and C-reactive protein levels in nonsmoking individuals with diabetes. Braz J Med Biol Res 2014; 47(5): 426-31.
[http://dx.doi.org/10.1590/1414-431X20143370] [PMID: 24760118]
[18]
Huang H, Guo Q, Li L, et al. Effect of type 2 diabetes mellitus on pulmonary function. Exp Clin Endocrinol Diabetes 2014; 122(6): 322-6.
[http://dx.doi.org/10.1055/s-0034-1372579] [PMID: 24941430]
[19]
Irfan M, Jabbar A, Haque AS, Awan S, Hussain SF. Pulmonary functions in patients with diabetes mellitus. Lung India 2011; 28(2): 89-92.
[http://dx.doi.org/10.4103/0970-2113.80314] [PMID: 21712938]
[20]
Lecube A, Sampol G, Muñoz X, Hernández C, Mesa J, Simó R. Type 2 diabetes impairs pulmonary function in morbidly obese women: a case-control study. Diabetologia 2010; 53(6): 1210-6.
[21]
Shafiee G, Khamseh ME, Rezaei N, Aghili R, Malek M. Alteration of pulmonary function in diabetic nephropathy. J Diabetes Metab Disord 2013; 12(15)(1): 5.
[22]
Shah SH, Sonawane P, Nahar P, Vaidya S, Salvi S. Pulmonary function tests in type 2 diabetes mellitus and their association with glycemic control and duration of the disease. Lung India 2013; 30(2): 108-12.
[http://dx.doi.org/10.4103/0970-2113.110417] [PMID: 23741090]
[23]
Tai H, Wang MY, Zhao YP, et al. Pulmonary Function and Retrobulbar Hemodynamics in Subjects With Type 2 Diabetes Mellitus. Respir Care 2017; 62(5): 602-14.
[http://dx.doi.org/10.4187/respcare.05129] [PMID: 28246307]
[24]
Wilms B, Ernst B, Thurnheer M, Spengler CM, Schultes B. Type 2 Diabetes is Associated with Lower Cardiorespiratory Fitness Independent of Pulmonary Function in Severe Obesity. Exp Clin Endocrinol Diabetes 2017; 125(5): 301-6.
[http://dx.doi.org/10.1055/s-0043-100102] [PMID: 28407668]
[25]
Uz-Zaman S, Banerjee J, Singhamahapatra A, et al. Assessment of lung function by spirometry and diffusion study and effect of glycemic control on pulmonary function in type 2 diabetes mellitus patients of the eastern India. J Clin Diagn Res 2014; 8(11): BC01-4.
[http://dx.doi.org/10.7860/JCDR/2014/9756.5076] [PMID: 25584206]
[26]
Hickson DA, Burchfiel CM, Liu J, et al. Diabetes, impaired glucose tolerance, and metabolic biomarkers in individuals with normal glucose tolerance are inversely associated with lung function: the Jackson Heart Study. Lung 2011; 189(4): 311-21.
[27]
Kim H, Jung YJ, Bae SJ, Choe J, Park JY, Lee K. Association of restrictive ventilatory dysfunction with insulin resistance and type 2 diabetes in koreans. Exp Clin Endocrinol Diabetes 2011; 119: 47-52.
[28]
Yamane T, Yokoyama A, Kitahara Y, et al. Cross-sectional and prospective study of the association between lung function and prediabetes. BMJ Open 2013; 3(2): 1-7.
[29]
Yamane T, Yokoyama A, Kitahara Y, et al. Cross-sectional and prospective study of the association between lung function and prediabetes. BMJ Open 2013; 3(2): 1-7.
[30]
Yeh F, Dixon AE, Marion S, et al. Obesity in adults is associated with reduced lung function in metabolic syndrome and diabetes: the Strong Heart Study. Diabetes Care 2011; 34(10): 2306-13.
[http://dx.doi.org/10.1136/bmjopen-2012-002179] [PMID: 23430597]
[31]
Giovannelli J, Trouiller P, Hulo S, et al. Low-grade systemic inflammation: a partial mediator of the relationship between diabetes and lung function. Ann Epidemiol 2018; 28(1): 26-32.
[http://dx.doi.org/10.1016/j.annepidem.2017.11.004] [PMID: 29223510]
[32]
Cichosz SL, Vestergaard ET, Hejlesen O. Muscle grip strength is associated to reduced pulmonary capacity in patients with diabetes. Prim Care Diabetes 2018; 12(1): 66-70.
[http://dx.doi.org/10.1016/j.pcd.2017.06.007] [PMID: 28705696]
[33]
Lee HM, Zhao Y, Liu MA, et al. Impact of lung-function measures on cardiovascular disease events in older adults with metabolic syndrome and diabetes. Clin Cardiol 2018; 41(7): 959-65.
[http://dx.doi.org/10.1002/clc.22985] [PMID: 29797803]
[34]
Sonoda N, Morimoto A, Tatsumi Y, et al. A prospective study of the impact of diabetes mellitus on restrictive and obstructive lung function impairment: The Saku study. Metabolism 2018; 82: 58-64.
[http://dx.doi.org/10.1016/j.metabol.2017.12.006] [PMID: 29288691]
[35]
Fuso L, Pitocco D, Condoluci C, et al. Decline of the lung function and quality of glycemic control in type 2 diabetes mellitus. Eur J Intern Med 2015; 26(4): 273-8.
[36]
Fuso L, Pitocco D, Condoluci C, et al. Decline of the lung function and quality of glycemic control in type 2 diabetes mellitus. Eur J Intern Med 2015; 26(4): 273-8.
[http://dx.doi.org/10.1016/j.ejim.2015.02.022] [PMID: 25770074]
[37]
Kim HY, Sohn TS, Seok H, et al. Prevalence and risk factors for reduced pulmonary function in diabetic patients: The Korea National Health and Nutrition Examination Survey. Korean J Intern Med (Korean Assoc Intern Med) 2017; 32(4): 682-9.
[http://dx.doi.org/10.3904/kjim.2016.045] [PMID: 28142231]
[38]
Uz-Zaman S, Banerjee J, Singhamahapatra A. Assessment of lung function by spirometry and diffusion study and effect of glycemic control on pulmonary function in type 2 diabetes mellitus patients of the eastern India. J Clin Diagn Res 2014; 8(11): 1-4.
[39]
Nandhini R, Syed Safina SSS. Respiratory Myopathy in Type II Diabetes Mellitus. J Clin Diagn Res 2012; 6(3): 354-7.
[40]
Popov D. Is lung a target of diabetic injury? The novel pro and cons evidences. Proc Rom Acad 2013; 15(2): 99-104.
[41]
Kuziemski K, Specjalski K, Jassem E. Diabetic pulmonary microangiopathy - fact or fiction? Endokrynol Pol 2011; 62(2): 171-6.
[PMID: 21528480]
[42]
Jagadapillai R, Rane MJ, Lin X, et al. Diabetic microvascular disease and pulmonary fibrosis: The contribution of platelets and systemic inflammation. Int J Mol Sci 2016; 17(11): 1-14.
[http://dx.doi.org/10.3390/ijms17111853] [PMID: 27834824]
[43]
Kopf S, Groener JB, Kender Z, et al. Breathlessness and restrictive lung disease: an important diabetes-related feature in patients with type 2 diabetes. Respiration 2018; 96(1): 29-40.
[http://dx.doi.org/10.1159/000488909] [PMID: 29874679]
[44]
van Enst WA, Scholten RJPM, Whiting P, Zwinderman AH, Hooft L. Meta-epidemiologic analysis indicates that MEDLINE searches are sufficient for diagnostic test accuracy systematic reviews. J Clin Epidemiol 2014; 67(11): 1192-9.
[http://dx.doi.org/10.1016/j.jclinepi.2014.05.008] [PMID: 24996667]
[45]
Halladay CW, Trikalinos TA, Schmid IT, Schmid CH, Dahabreh IJ. Using data sources beyond PubMed has a modest impact on the results of systematic reviews of therapeutic interventions. J Clin Epidemiol 2015; 68(9): 1076-84.
[http://dx.doi.org/10.1016/j.jclinepi.2014.12.017] [PMID: 26279401]

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