Prevention of Gestational Diabetes Mellitus (GDM) and Probiotics: Mechanism of Action: A Review

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Author(s): Aziz Homayouni, Nahal Bagheri, Sakineh Mohammad-Alizadeh-Charandabi, Neda Kashani, Noshin Mobaraki-Asl, Mojgan Mirghafurvand, Hanieh Asgharian, Fereshteh Ansari, Hadi Pourjafar*.

Journal Name: Current Diabetes Reviews

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Background: Gestational Diabetes Mellitus (GDM) is a health problem that is increasing around the world.

Introduction: Prevention of GDM, rather than treat, could have several benefits in both health and economic cost. Even a slight reduction of maternal glucose in non-diabetic women, particularly in women at high risk for GDM, may have significant benefits for pregnancy results and the future health of off-springs. Probiotics are a relatively new intervention which seems by impressing the mothers’ metabolism, can reduce blood sugar levels and prevent gestational diabetes and thus reduce the maternal and fetal complications resulting from it. The aim of this study was to review the studies on the prevention of gestational diabetes and assess the potentially beneficial aspects of probiotics on that and their possible mechanism of action.

Method: Articles compiled through clinical trials indexed in PubMed, Science Direct, Cochran, and Medlib between 2000 and 2017, with the keywords Probiotics, Prevention, and Gestational Diabetes Mellitus were selected.

Result: It seems by considering the potential of probiotics in modulation of gut microbiota, naturalization increased intestinal permeability, regulation of pro-inflammatory mediators’ secretion and thereby controlling local and systemic inflammation which results in decreasing intentional permeability, enhancing the immune system, it likely have the ability to prevent or control diabetes during pregnancy although confirmatory studies are still needed.

Conclusion: Experimental and clinical evidences support the supposition that the modulation of the gut microbiota via probiotic microorganisms could be effective in the prevention of gestational diabetes mellitus.

Keywords: Probiotics, gut microbiota, gestational diabetes mellitus, GDM, pregnancy

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(E-pub Ahead of Print)
DOI: 10.2174/1573399815666190712193828
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