Generic placeholder image

Current Respiratory Medicine Reviews

Editor-in-Chief

ISSN (Print): 1573-398X
ISSN (Online): 1875-6387

Case Report

Resolution of Empyema Thoracis after Patient Refusal of Surgical Intervention: A Case Series and Review of the Literature

Author(s): John H. Ferguson*

Volume 15, Issue 4, 2019

Page: [309 - 314] Pages: 6

DOI: 10.2174/1573398X15666190702164539

Abstract

Parapneumonic effusions occur commonly in patients hospitalised with pneumonia. Both complicated parapneumonic effusions and empyema are often managed initially with tube thoracostomy and intrapleural t-PA and DNase. If complete expansion of the lung is not achieved, surgical intervention is considered. We present three cases of patients with complicated parapneumonic effusions who experienced complete recovery despite declining surgical intervention and discuss the pitfalls in management. While very few patients have complete radiological resolution at the time of discharge, medical therapy is successful in at least 90% of cases. At 3-6 months from presentation, the radiological findings may improve significantly with antibiotic therapy. Surgery should be considered for patients with non-resolving sepsis markers including elevated temperature, C-reactive protein, and white blood cell count, in addition to non-improving imaging. Incomplete resolution of the parapneumonic effusion should not be considered a treatment failure, and attempts to normalise CT imaging may result in prolonged hospitalisation and unnecessary surgical intervention.

Keywords: Complicated parapneumonic effusion, decortication, empyema, pneumonia, VATS, surgical intervention.

Graphical Abstract
[1]
Light RW. Pleural Diseases. 6th ed. Philadelphia, PA: Lippincott Williams & Wilkins 2013.
[2]
Light RW, Girard WM, Jenkinson SG, George RB. Parapneumonic effusions. Am J Med 1980; 69(4): 507-12.
[http://dx.doi.org/10.1016/0002-9343(80)90460-X] [PMID: 7424940]
[3]
Biswas A, Jantz MA, Barnes MD, Mehta HJ. Management of noncommunicating multiloculated pleural space infection with fibrinolytic augmented multiple chest tube drainage. J Bronchology Interv Pulmonol 2016; 23(2): e14-7.
[http://dx.doi.org/10.1097/LBR.0000000000000263] [PMID: 27058724]
[4]
Misthos P, Sepsas E, Konstantinou M, Athanassiadi K, Skottis I, Lioulias A. Early use of intrapleural fibrinolytics in the management of postpneumonic empyema. A prospective study. Eur J Cardiothorac Surg 2005; 28(4): 599-603.
[http://dx.doi.org/10.1016/j.ejcts.2005.07.005] [PMID: 16129614]
[5]
Strange C, Sahn SA. The clinician’s perspective on parapneumonic effusions and empyema. Chest 1993; 103(1): 259-61.
[http://dx.doi.org/10.1378/chest.103.1.259] [PMID: 8417890]
[6]
Rahman NM, Maskell NA, West A, et al. Intrapleural use of tissue plasminogen activator and DNase in pleural infection. N Engl J Med 2011; 365(6): 518-26.
[http://dx.doi.org/10.1056/NEJMoa1012740] [PMID: 21830966]
[7]
Teixeira LR, Sasse SA, Villarino MA, Nguyen T, Mulligan ME, Light RW. Antibiotic levels in empyemic pleural fluid. Chest 2000; 117(6): 1734-9.
[http://dx.doi.org/10.1378/chest.117.6.1734] [PMID: 10858410]
[8]
Berger HA, Morganroth ML. Immediate drainage is not required for all patients with complicated parapneumonic effusions. Chest 1990; 97(3): 731-5.
[http://dx.doi.org/10.1378/chest.97.3.731] [PMID: 2306975]
[9]
Rahman NM, Kahan BC, Miller RF, Gleeson FV, Nunn AJ, Maskell NA. A clinical score (RAPID) to identify those at risk for poor outcome at presentation in patients with pleural infection. Chest 2014; 145(4): 848-55.
[http://dx.doi.org/10.1378/chest.13-1558] [PMID: 24264558]
[10]
Piccolo F, Pitman N, Bhatnagar R, et al. Intrapleural tissue plasminogen activator and deoxyribonuclease for pleural infection. An effective and safe alternative to surgery. Ann Am Thorac Soc 2014; 11(9): 1419-25.
[http://dx.doi.org/10.1513/AnnalsATS.201407-329OC] [PMID: 25296241]
[11]
Majid A, Kheir F. Concurrent intrapleural installation of tissue plasminogen activator and DNase for pleural infection. Ann Am Thorac Soc 2016; 13(9): 1512-8.
[http://dx.doi.org/10.1513/AnnalsATS.201602-127OC] [PMID: 27333122]
[12]
Mehta HJ, Biswas A, Penley AM, Cope J, Barnes M, Jantz MA. Management of intrapleural sepsis with once daily use of tissue plasminogen activator and deoxyribonuclease. Respiration 2016; 91(2): 101-6.
[http://dx.doi.org/10.1159/000443334] [PMID: 26761711]
[13]
Popowicz N, Bintcliffe O, De Fonseka D, et al. Dose de-escalation of intrapleural tissue plasminogen activator therapy for pleural infection. The alteplase dose assessment for pleural infection therapy project. Ann Am Thorac Soc 2017; 14(6): 929-36.
[http://dx.doi.org/10.1513/AnnalsATS.201609-673OC] [PMID: 28324671]
[14]
Bishwakarma R, Shah S, Frank L, Zhang W, Sharma G, Nishi SP. Mixing it up: coadministration of tPA/DNase in complicated parapneumonic pleural effusions and empyema. J Bronchology Interv Pulmonol 2017; 24(1): 40-7.
[http://dx.doi.org/10.1097/LBR.0000000000000334] [PMID: 27984384]
[15]
Maskell NA, Davies CWH, Nunn AJ, et al. U.K. Controlled trial of intrapleural streptokinase for pleural infection. N Engl J Med 2005; 352(9): 865-74.
[http://dx.doi.org/10.1056/NEJMoa042473] [PMID: 15745977]
[16]
Diacon AH, Theron J, Schuurmans MM, Van de Wal BW, Bolliger CT. Intrapleural streptokinase for empyema and complicated parapneumonic effusions. Am J Respir Crit Care Med 2004; 170(1): 49-53.
[http://dx.doi.org/10.1164/rccm.200312-1740OC] [PMID: 15044206]
[17]
Cremonesini D, Thomson AH. How should we manage empyema: antibiotics alone, fibrinolytics, or primary video-assisted thoracoscopic surgery (VATS)? Semin Respir Crit Care Med 2007; 28(3): 322-32.
[http://dx.doi.org/10.1055/s-2007-981653] [PMID: 17562502]
[18]
Long AM, Smith-Williams J, Mayell S, Couriel J, Jones MO, Losty PD. ‘Less may be best’-Pediatric parapneumonic effusion and empyema management: Lessons from a UK center. J Pediatr Surg 2016; 51(4): 588-91.
[http://dx.doi.org/10.1016/j.jpedsurg.2015.07.022] [PMID: 26382287]
[19]
Wait MA, Sharma S, Hohn J, Dal Nogare A. A randomized trial of empyema therapy. Chest 1997; 111(6): 1548-51.
[http://dx.doi.org/10.1378/chest.111.6.1548] [PMID: 9187172]
[20]
Davies CW, Kearney SE, Gleeson FV, Davies RJ. Predictors of outcome and long-term survival in patients with pleural infection. Am J Respir Crit Care Med 1999; 160(5 Pt 1): 1682-7.
[http://dx.doi.org/10.1164/ajrccm.160.5.9903002] [PMID: 10556140]

© 2024 Bentham Science Publishers | Privacy Policy