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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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General Review Article

Bioactivities of Natural Catalpol Derivatives

Author(s): Liu-Qiang Zhang, Kai-Xian Chen* and Yi-Ming Li*

Volume 26, Issue 33, 2019

Page: [6149 - 6173] Pages: 25

DOI: 10.2174/0929867326666190620103813

Price: $65

Abstract

Catalpol, a famous molecule of iridoids, possesses extensive pharmacological activities. Our studies found that compounds with low-polarity substituents at the 6-O position of catalpol exhibited higher NF-κB inhibitory potency than catalpol. However, catalpol derivatives are not much focused. Here this review provides extensive coverage of naturally occurring catalpol derivatives discovered from 1888 until 2018. It covers their distribution, chemotaxonomic significance, chemical structures, and bioactivities from more than 200 peer-reviewed articles, and highlights the structure-activity relationship of catalpol derivatives.

Keywords: Catalpol derivatives, 6-O substituent, Structure-activity relationship, anti-inflammatory activity, antioxidative activity, NF-κB inhibitory potency.

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