Login Register Cart 0
Generic placeholder image

Current Traditional Medicine

Editor-in-Chief

ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

Phytochemical, Analytical and Medicinal Studies of Holoptelea integrifolia Roxb. Planch - A Review

Author(s): Vijay Kumar*, Simranjeet Singh, Ragini Bhadouria, Ravindra Singh and Om Prakash

Volume 5, Issue 4, 2019

Page: [270 - 277] Pages: 8

DOI: 10.2174/2215083805666190521103308

Price: $65

Abstract

Holoptelea integrifolia Roxb. Planch (HI) has been used to treat various ailments including obesity, osteoarthritis, arthritis, inflammation, anemia, diabetes etc. To review the major phytochemicals and medicinal properties of HI, exhaustive bibliographic research was designed by means of various scientific search engines and databases. Only 12 phytochemicals have been reported including biologically active compounds like betulin, betulinic acid, epifriedlin, octacosanol, Friedlin, Holoptelin-A and Holoptelin-B. Analytical methods including the Thin Layer Chromatography (TLC), High-Performance Thin Layer Chromatography (HPTLC), High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography With Mass Spectral (LC-MS) analysis have been used to analyze the HI. From medicinal potency point of view, these phytochemicals have a wide range of pharmacological activities such as antioxidant, antibacterial, anti-inflammatory, and anti-tumor. In the current review, it has been noticed that the mechanism of action of HI with biomolecules has not been fully explored. Pharmacology and toxicological studies are very few. This seems a huge literature gap to be fulfilled through the detailed in-vivo and in-vitro studies.

Keywords: Holoptelea integrifolia Roxb. Planch, chemistry, phytochemistry, analytical methods, pharmacology, toxicology.

Graphical Abstract

[1]
Newman DJ, Cragg GM. Natural products as sources of new drugs from 1981 to 2014. J Nat Prod 2016; 79(3): 629-61.
[http://dx.doi.org/10.1021/acs.jnatprod.5b01055] [PMID: 26852623]
[2]
Aremu AO, Finnie JF, Van SJ. Potential of South African medicinal plants used as anthelmintics - their efficacy, safety concerns and reappraisal of current screening methods. S Afr J Bot 2012; 82: 134-50.
[http://dx.doi.org/10.1016/j.sajb.2012.05.007]
[3]
Srinivas RB, Kiran KRR, Naidu VGM, et al. Evaluation of antimicrobial, antioxidant and wound-healing potentials of Holoptelea integrifolia. J Ethnopharmacol 2008; 115(2): 249-56.
[http://dx.doi.org/10.1016/j.jep.2007.09.031] [PMID: 18037253]
[4]
Sutar RC, Kasture SB, Kalaichelvan VK. Fingerprinting analysis of the phytosterols from Holoptelea Integrifolia (Roxb.) Planch leaves using high-performance thin layer chromatography analysis. Asian J Pharm Clinical Res 2014; 7(4): 160-4.
[5]
Sutar RC, Musmade DS, Agasti L. HPTLC finger printing analysis of the alkaloids from Holoptelea integrifolia (Roxb.) Planch leaves. J Pharm Phytochem 2016; 5(4): 215-9.
[6]
Kavitha CA, Narasu ML. HPLC analysis and antioxidant activities of Holoptelea Integrifolia. Int J Chem Sci 2015; 13(2): 1014-26.
[7]
Subash AK, Augustine A. Hypolipidaemic effects of methanol extract of Holoptelea integrifolia (Roxb.) Planchon bark in diet-induced obese rats. Appl Biochem Biotechnol 2013; 169(2): 546-53.
[http://dx.doi.org/10.1007/s12010-012-9993-0] [PMID: 23239412]
[8]
Kavitha CA, Narasu ML. Comparative evaluation of antimicrobial activities of root, stem and leaves of Holoptelea Integrifolia against pathogenic bacteria. Asian J Microbio Biotech Environ Sci 2014; 16: 145-54.
[9]
Saraswathy A, Devi SN, Ramasamy D. Antioxidant, heavy metals and elemental analysis of Holoptelea integrifolia Planch. Indian J Pharm Sci 2008; 70(5): 576.
[http://dx.doi.org/10.4103/0250-474X.45419] [PMID: 21394277]
[10]
Ganie SA, Yadav SS. FT-IR spectroscopic analysis of Holoptelea integrifolia (Roxb.) Planch seed extracts and their antibacterial activity. Res J Med Plant 2015; 9(8): 417-26.
[http://dx.doi.org/10.3923/rjmp.2015.417.426]
[11]
Ganie SA, Yadav SS. Holoptelea integrifolia (Roxb.) Planch: A review of its ethnobotany, pharmacology, and phytochemistry. BioMed Res Int 2014; 2014(40): 12-3.
[http://dx.doi.org/10.1155/2014/401213] [PMID: 24949441]
[12]
Kumar D, Kumar K, Gupta J, Bishnoi N, Kumar S. A mini review on chemistry and biology of Holoptelea integrifolia Roxb. Planch (Ulmaceae). Asian Pac J Trop Biomed 2012; 2(2): 1200-5.
[http://dx.doi.org/10.1016/S2221-1691(12)60384-0]
[13]
Kumar V, Singh S, Singh R, et al. Spectral, structural and energetic study of acephate, glyphosate, monocrotophos and phorate: An experimental and computational approach. J Taibah University Sci 2018; 12: 69-78.
[http://dx.doi.org/10.1080/16583655.2018.1451109]
[14]
Kumar V, Chawla M, Cavallo L, et al. Complexation of trichlorosalicylic acid with alkaline and first row transition metals as a switch for their antibacterial activity. Inorg Chim Acta 2018; 469: 379-86.
[http://dx.doi.org/10.1016/j.ica.2017.08.064]
[15]
Singh S, Kumar V, Chauhan A, et al. Toxicity, degradation and analysis of the herbicide atrazine. Environ Chem Lett 2018; 16: 211-37.
[http://dx.doi.org/10.1007/s10311-017-0665-8]
[16]
Kaur S, Kumar V, Chawla M, Cavallo L, Poater A, Upadhyay N. Pesticides curbing soil fertility: Effect of complexation of free metal ions. Front Chem 2017; 5: 43.
[http://dx.doi.org/10.3389/fchem.2017.00043] [PMID: 28725644]
[17]
Kumar V, Singh S, Singh R, Upadhyay N, Singh J. Design, synthesis, and characterization of 2,2-bis(2,4-dinitrophenyl)-2-(phosphonatomethylamino)acetate as a herbicidal and biological active agent. J Chem Biol 2017; 10(4): 179-90.
[http://dx.doi.org/10.1007/s12154-017-0174-z] [PMID: 29075355]
[18]
Kumar V, Kumar V, Kaur S, Singh S, Upadhyay N. Unexpected formation of N-phenyl-thiophospho-rohydrazidic acid O,S-dimethyl ester from acephate: Chemical biotechnical and computational study. Biotech 2016; 6: 1-11.
[19]
Kumar V, Upadhyay N, Kumar V, Sharma S. A review on sample preparation and chromatographic determination of acephate and methamidophos in different samples. Arab J Chem 2015; 8: 624-31.
[http://dx.doi.org/10.1016/j.arabjc.2014.12.007]
[20]
Kumar V, Singh S, Singh J, Upadhyay N. Potential of plant growth promoting traits by bacteria isolated from heavy metal contaminated soils. Bull Environ Contam Toxicol 2015; 94(6): 807-14.
[http://dx.doi.org/10.1007/s00128-015-1523-7] [PMID: 25782590]
[21]
Kumar V, Upadhyay N, Manhas A. Designing syntheses characterization computational study and biological activities of silver-phenothiazine metal complex. J Mol Struct 2015; 1099: 135-40.
[http://dx.doi.org/10.1016/j.molstruc.2015.06.055]
[22]
Kumar V, Upadhyay N, Sharma S. Interactions of atrazine with transition metal ions in aqueous media: Experimental and computational approach. Biotech 2015; 5: 791-8.
[23]
Sharma S, Khatri P, Pandey A, Jakhetia V, Chaturvedi L, Dwivedi N. Anti-diabetic screening of leaves extract of Holoptelea integrifolia Roxb. Int J Pharm Res Dev 2010; 2: 66-71.
[24]
Sharma J, Sharma SC, Sarangdevot YS, Vyas B. Study of antidiabetic activity of the stem bark extract of Holoptelea integrifolia (Roxb.). Res J Pharmacol Pharmacodynam 2012; 4: 181-4.
[25]
Sharma S, Lakshmi KS, Patidar A, Chaudhary A, Dhaker S. Studies on anti-inflammatory effect of aqueous extract of leaves of Holoptelea integrifolia, Planch. in rats. Indian J Pharmacol 2009; 41(2): 87-8.
[http://dx.doi.org/10.4103/0253-7613.51348] [PMID: 20336224]
[26]
Kalpana UA. Anti-inflammatory evaluation of ethanolic extract of leaves of Holoptelea integrifolia Planch. Scholars Res Lib 2010; 1: 185-95.
[27]
Lakshmi KS, Sharma SS, Rajesh T, Chitra V. Antitumour activity of ethanolic extract of leaves of Holoptelea integrifolia on Dalton’s ascitic lymphoma in Swiss albino mice. Int J Green Pharm 2010; 4: 44-7.
[http://dx.doi.org/10.4103/0973-8258.62164]
[28]
Soujanya J, Silambujanaki P, Krishna VL. Anticancer efficacy of Holoptelea integrifolia, Planch. against 7, 12-dimethyl benz(a)anthracene induced breast carcinoma in experimental rats. Int J Pharm Pharm Sci 2011; 3: 103-6.
[29]
Guo H, Wang DS, Rizwani GH, et al. Antineoplastic activity of Holoptelea integrifolia (Roxb.) Planch bark extracts (in vitro). Pak J Pharm Sci 2013; 26(6): 1151-6.
[PMID: 24191320]
[30]
Saraswathy A, Devi SN, Ramasamy D. Antioxidant, heavy metals and elemental analysis of Holoptelea Integrifolia Planch. Indian J Pharm Sci 2008; 70(5): 683-576.
[http://dx.doi.org/10.4103/0250-474X.45419] [PMID: 21394277]
[31]
Srivastava J, Dwivedi KN, Pandey HP. Assessment of antioxidant activity and total phenolic content of aqueous stem bark extract of Holoptelea integrifolia Planch. Int J Pharm Pharm Sci 2013; 5: 357-61.
[32]
Vinod NV, Haridas M, Sadasivan C. Isolation of 1,4-naphthalenedione, an antibacterial principle from the leaves of Holoptelea integrifolia and its activity against beta-lactam resistant Staphylococcus aureus. Indian J Biochem Biophys 2010; 47(1): 53-5.
[PMID: 21086756]
[33]
Padmaa P, Durga N. Antibacterial activity of different extracts of stem bark of Holoptelea integrifolia. Int Res J Pharm 2011; 2: 111-3.
[34]
Ahmad S, Sharma R, Mahajan S, Agnihotri R, Gupta A. Antibacterial evaluation and preliminary phytochemical analysis of the leaf extract of Holoptelea Integrifolia. J Pharm Res 2012; 5: 3823-5.
[35]
Joshi SD, Hallikeri CS, Kulkarni VH. Evaluation of antibacterial and antitubercular activities of Holoptelea Integrifolia (Roxb) Planch bark. Universal J Pharm 2013; 2: 87-90.
[36]
Sahoo KK, Yadav VK, Saxena AR. Antifungal properties of Holoptelea integrifolia (Roxb.) Planch. Ann Plant Prot Sci 2012; 18: 438-42.
[37]
Ishnava KB, Chauhan KB, Bhatt CA. Screening of antifungal activity of various plant leaves extracts from Indian plants. Arch Phytopathol Pflanzenschutz 2012; 45: 152-60.
[http://dx.doi.org/10.1080/03235408.2010.505777]
[38]
Singha S, Adhikari U, Ghosh A, Chandra G. Mosquito larvicidal potentiality of Holoptelea integrifolia leaf extract against Japanese encephalitis vector, culex vishuni. J Mosquito Res 2012; 2: 25-31.
[39]
Shrinivas S, Ravindra K, Aradhana M, Kailash B. Ethanolic leaf extract of Holoptelea integrifolia Planch. Decreases cisplatin-induced pica in rats. J Pharmacol 2008; 7: 293-7.

Rights & Permissions Print Cite
Article Metrics
40
3
© 2024 Bentham Science Publishers | Privacy Policy