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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Review Article

Structural Diversity Attributed by Aza-Diels-Alder Reaction in Synthesis of Diverse Quinoline Scaffolds

Author(s): Dharmender Singh, Vipin Kumar, Chandi C. Malakar* and Virender Singh*

Volume 23, Issue 8, 2019

Page: [920 - 958] Pages: 39

DOI: 10.2174/1385272823666190423140805

Price: $65

Abstract

In recent years, the synthesis of quinoline scaffold using various methodological devices has attracted considerable attention in synthetic chemist community. The most feasible method to serve this purpose is Aza-Diels-Alder reaction which provides flexibility and diversity in the synthesis of quinoline decorated with different functionalities over the scaffold. Diversity in this functionality improvises the susceptibility of the quinoline scaffold for various protein targets. This review encompasses multifactorial aspects of Aza-Diels-Alder reaction as well as provides insights into the synthetic schemes for quinoline scaffold.

Keywords: Aza-Diels-Alder, quinoline, catalysis, povarov, diastereoselective, multicomponent.

Graphical Abstract
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