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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Review Article

Recent Developments in the de Novo Synthesis of Heterocycles by First-Row Transition-Metal-Catalyzed Acceptorless Dehydrogenation

Author(s): V. Arun* and Suman De Sarkar*

Volume 23, Issue 9, 2019

Page: [1005 - 1018] Pages: 14

DOI: 10.2174/1385272823666190423125226

Price: $65

Abstract

Applications of Acceptorless Dehydrogenation (AD) process for the synthesis of important heterocycles are discussed. The key features of AD process are the generation of more reactive carbonyl/imine compounds from alcohols/amines by the release of dihydrogen as a stoichiometric byproduct. In this review, we document recent advances in this field by using first row transition metal catalysts and easily accessible coupling partners, thus offering cost-effective access to different heterocyclic rings.

Keywords: Hydrogen transfer, alcohols, transition-metal, dehydrogenation, heterocycles, acceptorless dehydrogenation.

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