Rapid Characterization of Quorum Sensing Inhibitory Molecules from Garcinia indica Choisy Seed Methanol Extract by GC-MS Analysis

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Author(s): Rajesh P Shastry*, Mohammed Aman.

Journal Name: Current Bioactive Compounds

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Bacteria communicate by producing small signalling molecules to maintain threshold cell density. Quorum sensing inhibition is an effective and most potent approach for the prevention of cell to cell communication. In present study, the methanolic extract of Garcinia indica was tested for the anti-quorum sensing activity using Chromobacterium violaceum as a biosensor. The extract inhibited violacein production in biosensor strain without affecting the growth of the bacteria and this was supported by bioautography assay. The bioactive fraction was analysed by aid of GC-MS and revealed that, the presence of coumarin (7-hydroxy-3-(1,1-dimethylprop-2-enyl) coumarin) and eugenol (1,2-dimethoxy-4-(1-methoxy-1-propenyl) benzene) derivatives as anti-quorum sensing molecules. A detailed study is needed to investigate the possible applications and mode of action for the control of quorum sensing signals.

Keywords: Anti-quorum sensing, Coumarin, Eugenol, Garcinia indica, plant seed extra

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(E-pub Ahead of Print)
DOI: 10.2174/1573407215666190408120140
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