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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Letter Article

Ultrasonic Assisted Synthesis of 2, 3-Dihydroquinazolin-4(1H)-ones Involving Three-Component Reaction of Isatoic Anhydride, Amines and Pyrazole Carbaldehydes Catalyzed by [γ-Fe2O3@HAp-SO3H]

Author(s): Kiana F. Sina, Asieh Yahyazadeh*, Nosrat O. Mahmoodi, Kurosh R. Moghadam, Mohammad Nikpassand and Mahdi Rasa

Volume 17, Issue 1, 2020

Page: [24 - 30] Pages: 7

DOI: 10.2174/1570178616666190401183953

Price: $65

Abstract

The combination of [γ-Fe2O3@HAp-SO3H] as a catalyst and ultrasonic effect catalyzed the synthesis of diverse derivatives of 2, 3-dihydroquinazolin-4(1H)-ones which is reported in this study. The products were synthesized via the one-pot three-component reaction of isatoic anhydride, amines and pyrazole carbaldehydes in water: EtOH catalyzed by recoverable [γ-Fe2O3@HAp-SO3H]. This paper conducted an investigation of the effect of various solvents, temperatures and catalysts on the reactions. Short reaction times, mild reaction conditions, simple work-up, the desired yields and the use of an appropriate catalyst are the advantages of this novel method. The new derivatives were validated by using FT-IR, 1HNMR, and 13CNMR. Moreover, the synthesized compounds were screened for their antimicrobial activity against bacterial strains.

Keywords: 2, 3-Dihydroquinazolinone, pyrazole carbaldehydes, ultrasonic, [γ-Fe2O3@HAp-SO3H], catalyst, one-pot threecomponent reaction.

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